Cepstral analysis in patients with a vocal fold motility impairment: advantages of the cepstrum over time-based acoustic analysis

Delgado-Vargas, Beatriz; Cervera, Leticia Acle; López, Lorena; Bonet-Loscertales, Mireya; Pérez-Naranjo, Narcisa; Fuentes-Navajo, Patricia

doi:10.1007/s00405-020-06291-2

Cited by 4 publications

(1 citation statement)

References 15 publications

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“…3 Cepstral peak prominence smoothed (CPPS) is another potential measure, since increased flow resulting from presence of glottal gap produces increased noise energy compared to harmonic energy at higher frequencies (often perceived as breathiness). [10][11][12] Significant decreases in CPPS measures have been reported for sustained vowels between UVFP patients and controls [13][14][15][16][17][18] and presbylarynges patients and controls. 14 Glottal Function Index (GFI) 19 is another potential measure.…”

Section: Introductionmentioning

confidence: 96%

Predicting Airflow from Measures Sensitive to Mid-cord Glottal Gap During the COVID-19 Pandemic

Niermeyer

Diao

Bielamowicz

et al. 2023

Ann Otol Rhinol Laryngol

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Objectives: To determine if trans-laryngeal airflow, important in assessing vocal function in paresis/paralysis and presbylarynges patients with mid-cord glottal gaps, could be predicted by other measures sensitive to mid-cord glottal gap size but with smaller risks of spreading COVID-19, and if any patient factors need consideration. Methods: Four populations were: unilateral vocal fold paresis/paralysis (UVFP, 148), aging and UVFP (UVFP plus aging, 22), bilateral vocal fold paresis/paralysis without airway obstruction (BVFP, 49), and presbylarynges (66). Five measures were selected from the initial clinic visit: mean airflow from repeated /pi/ syllables, longer of 2 /s/ and 2 /z/ productions, higher of 2 cepstral peak prominence smoothed for vowel /a/ (CPPSa), and Glottal Function Index (GFI). S/Z ratios were computed. Stepwise regression models used 3 measures and 5 patient factors (age, sex, etiology, diagnosis, and potentially impaired power source for voicing) to predict airflow. Results: Log-transformations were required to normalize distributions of airflow and S/Z ratio. The final model revealed age, sex, impaired power source, log-transformed S/Z ratio, and GFI predicted log-transformed airflow ( R2 = .275, F[5,278] = 21.1; P < .001). Conclusions: The amount of variance explained by the model was not high, suggesting adding other predictive variables to the model might increase the variance explained.

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Section: Introductionmentioning

confidence: 96%

Predicting Airflow from Measures Sensitive to Mid-cord Glottal Gap During the COVID-19 Pandemic

Niermeyer

Diao

Bielamowicz

et al. 2023

Ann Otol Rhinol Laryngol

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Scaffold‐Forming Collagen and Motor‐Endplate Expressing Muscle Cells for Porcine Laryngoplasty

Shay,

Morrison,

Zhang

et al. 2024

The Laryngoscope

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ObjectiveVocal fold paralysis impairs quality of life, and no curative injectable therapy exists. We evaluated injection of a novel in situ polymerizing (scaffold‐forming) collagen in the presence and absence of muscle‐derived motor‐endplate expressing cells (MEEs) to promote medialization and recurrent laryngeal nerve (RLN) regeneration in a porcine model of unilateral vocal fold paralysis.MethodsTwelve Yucatan minipigs underwent right RLN transection. Autologous muscle progenitor cells were isolated from muscle biopsies, differentiated, and induced to MEEs. Three weeks after RLN injury, animals received injections of collagen, collagen containing MEEs, or saline into the paralyzed right vocal fold. Stimulated laryngeal electromyography and acoustic vocalization were used for function assessments. Larynges were harvested and underwent histologic, gene expression, and further quantitative analyses.ResultsInjections were well‐tolerated, with the collagen scaffold showing immunotolerance and collagen‐encapsulated MEEs remaining viable. Collagen‐treated paralyzed vocal folds showed increased laryngeal adductor muscle volumes relative to that of the uninjured side, with those receiving MEEs and collagen showing the highest volumes. Muscles injected with MEEs and collagen demonstrated increased expression of select neurotrophic (BDNF and NTN1), motor‐endplate (DOK7, CHRNA1, and MUSK), and myogenic (MYOG and MYOD) related genes relative to saline controls.ConclusionIn a porcine model of unilateral vocal fold paralysis, injection of in situ polymerizing collagen in the absence and presence of MEEs enhanced laryngeal adductor muscle volume, modulated expression of neurotrophic and myogenic factors, and avoided adverse material‐mediated immune responses. Further study is needed to determine long‐term functional outcomes with this novel therapeutic approach.Level of EvidenceNA Laryngoscope, 2024

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Effect of Smoking on Cepstral Parameters

Wei,

Zhang,

et al. 2024

Journal of Voice

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Cepstral analysis in patients with a vocal fold motility impairment: advantages of the cepstrum over time-based acoustic analysis

Cited by 4 publications

References 15 publications

Predicting Airflow from Measures Sensitive to Mid-cord Glottal Gap During the COVID-19 Pandemic

Predicting Airflow from Measures Sensitive to Mid-cord Glottal Gap During the COVID-19 Pandemic

Scaffold‐Forming Collagen and Motor‐Endplate Expressing Muscle Cells for Porcine Laryngoplasty

Effect of Smoking on Cepstral Parameters

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