Ceramic Scaffolds, Current Issues and Future Trends

Roohani‐Esfahani, Seyed‐Iman; Zreiqat, Hala

doi:10.1002/9781118371183.ch2

Cited by 4 publications

(5 citation statements)

References 155 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, relatively stronger scaffolds can be made from bioactive GCs that may be candidates for load‐bearing sites . Therefore, almost all commercial bioactive GCs and others being developed have been the subject of study for scaffold development using various fabrication techniques, including, for example, foam‐replication methods, salt or sugar leaching, thermally induced phase separation, microsphere emulsification sintering, electrospinning to form nanofibrous structures, computer‐assisted rapid prototyping techniques and so forth , . More recently, Fiocco et al and Elsayed et al have used novel approach based on the use of preceramic polymers to develop porous bioactive GCs.…”

Section: Bioactive Gc Scaffoldsmentioning

confidence: 99%

“…85,86 Therefore, almost all commercial bioactive GCs and others being developed have been the subject of study for scaffold development using various fabrication techniques, including, for example, foamreplication methods, salt or sugar leaching, thermally induced phase separation, microsphere emulsification sintering, electrospinning to form nanofibrous structures, computer-assisted rapid prototyping techniques and so forth. 85,86,[90][91][92][93] More recently, Fiocco et al 94,95 and Elsayed et al 96 have used novel approach based on the use of preceramic polymers to develop porous bioactive GCs. GCs derive from thermal treatment of preceramic polymers, in the form of silicone resins, containing micro-and nanosized filler powders such as Ca/Mg-carbonate, Na-carbonate, Naphosphate or even glass particles.…”

Section: Bioactive Gc Scaffoldsmentioning

confidence: 99%

See 1 more Smart Citation

History and trends of bioactive glass‐ceramics

Montazerian

Zanotto

2016

J Biomedical Materials Res

134

119

View full text Add to dashboard Cite

The interest around bioactive glass-ceramics (GCs) has grown significantly over the last two decades due to their appropriate biochemical and mechanical properties. The intense research effort in this field has led to some new commercial products for biomedical applications. This review article begins with the basic concepts of GC processing and development via controlled heat treatments of monolithic pieces or sinter-crystallization of powdered glasses. We then go on to describe the processing, properties, and applications of some commercial bioactive GCs and discuss selected valuable reported researches on several promising types of bioactive GCs. The article finishes with a section on open relevant research directions for bioactive GC development.

show abstract

Section: Bioactive Gc Scaffoldsmentioning

confidence: 99%

Section: Bioactive Gc Scaffoldsmentioning

confidence: 99%

History and trends of bioactive glass‐ceramics

Montazerian

Zanotto

2016

J Biomedical Materials Res

134

119

View full text Add to dashboard Cite

show abstract

“…29 However, one major challenge to researchers is how to obtain a highly porous scaffold with sufficient mechanical strength. 30 The range of compres sive strength for cancellous bone has been iden tified as between 1.4 and 45 MPa. 31 Stressstrain curves are generally used to evaluate the stress level at varying levels of load or force.…”

Section: Attenuated Total Reflection -Fourier Transforms Infrared (At...mentioning

confidence: 99%

Biomineralization of carboxymethyl cellulose-sodium alginate infused with cellulose nanocrystals for bone regeneration

Bakhiet

Johari

Hussain

et al. 2023

Journal of Bioactive and Compatible Polymers

View full text Add to dashboard Cite

The development of novel tissue constructs from both natural and synthetic biopolymers has attracted widespread attention among researchers, prior to its excellent outcomes in bone tissue regeneration. This research aims to investigate the biocompatibility of carboxymethyl cellulose (CMC)/sodium alginate (SA) embedded with cellulose nanocrystals (CNC) and its surface response due to the biomineralization process as potential implant material. The CMC/SA were prepared with and without CNC using water as the only solvent. It was then freeze-dried for up to 72 h before being further immersed in simulated body fluid (SBF) for comparative studies. Morphological observation by scanning electron microscope (SEM) showed that CMC/SA/CNC (SBF) displayed a spherical apatite structure amid interconnected porous materials with an average particle diameter between 95 and 148 nm. The apatite crystal indicated the existence of calcium (Ca) and phosphorus (P) elements, which was confirmed by energy dispersive X-ray analysis (EDX). All scaffolds showed a porosity of up to 90.13% with a moderate degradation rate and a water absorption value of up to 1100%. Overall, all scaffolds had open, interconnected pore sizes ranging from 40 to 400 µm. Attenuated total reflection – Fourier Transform Infrared (ATR-FTIR) spectroscopy and thermogravimetric analysis (TGA) curve showed a new existing peak and lower decomposition rate, respectively, for SBF-treated scaffolds. Stress-strain curve disclosed the highest tensile stress of CMC/SA/CNC (SBF) at 16.2 MPa and 15.75% strain effect. Preliminary in vitro cytotoxicity studies performed with human foetal osteoblast (hFOB) cells showed that cytocompatibility was more evident on CMC/SA/CNC (SBF) scaffolds. This study showed that scaffold-embedded CNC with SBF treatment could be hit upon as material selection for bone tissue engineering.

show abstract

“…More interestingly, we aim to investigate in future studies the improvements that can be brought by increasing the fiber overlap, without lowering porosity. This has been recently shown to be achievable by printing in hexagonal patterns [38].…”

Section: Mechanical Testing Of Scaffolds Under Compressionmentioning

confidence: 99%

Additive manufactured scaffolds for bone tissue engineering: physical characterization of thermoplastic composites with functional fillers

Sinha

Sánchez²,

Cámara-Torres

et al. 2021

Preprint

View full text Add to dashboard Cite

Thermoplastic polymer – filler composites are excellent materials for bone tissue engineering (TE) scaffolds, combining the functionality of fillers with suitable load bearing ability, biodegradability, and additive manufacturing (AM) compatibility of the polymer. Two key determinants of their utility are their rheological behavior in the molten state, determining AM processability, and their mechanical load-bearing properties. We report here the characterization of both these physical properties for four bone TE relevant composite formulations with poly(ethylene oxide terephthalate) / poly(butylene terephthalate (PEOT/PBT) as a base polymer, which is often used to fabricate TE scaffolds. The fillers used were reduced graphene oxide (rGO), hydroxyapatite (HA), gentamycin intercalated in zirconium phosphate (ZrP-GTM) and ciprofloxacin intercalated in MgAl layered double hydroxide (MgAl-CFX). The rheological assessment showed that generally the viscous behavior dominated the elastic behavior (G’’ > G’) for the studied composites, at empirically determined extrusion temperatures. Coupled rheological-thermal characterization of ZrP-GTM and HA composites showed that the fillers increased the solidification temperatures of the polymer melts during cooling. Both these findings have implications for the required extrusion temperatures and bonding between layers. Mechanical tests showed that the fillers generally made the polymer stiffer but more brittle in proportion to the filler fractions. Furthermore, the elastic moduli of scaffolds did not directly correlate with the corresponding bulk material properties, implying composite-specific AM processing effects on the mechanical properties. Lastly, we show computational models to predict multi-material scaffold elastic moduli using measured single material scaffold and bulk moduli. The reported characterizations are essential for assessing the AM processability and ultimately the suitability of the manufactured scaffolds for the envisioned bone regeneration application.

show abstract

Ceramic Scaffolds, Current Issues and Future Trends

Cited by 4 publications

References 155 publications

History and trends of bioactive glass‐ceramics

History and trends of bioactive glass‐ceramics

Biomineralization of carboxymethyl cellulose-sodium alginate infused with cellulose nanocrystals for bone regeneration

Additive manufactured scaffolds for bone tissue engineering: physical characterization of thermoplastic composites with functional fillers

Contact Info

Product

Resources

About