This paper attempts to measure the jet flow field of different nozzles accurately, and optimize the effect of the jetting devices. For this purpose, four nozzles with different structures were physically and mathematically modelled, including conical-cylindrical nozzle, conical nozzle, cylindrical nozzle and streamlined nozzle. The turbulence was described by the improved standard k-epsilon (k-ε) turbulence model. Then, the measurement space was meshed into unstructured triangular grids, with high grid density in key areas. Next, the flow field inside and outside each nozzle was simulated on ANSYS Fluent, and the jet velocity field distribution at different positions, velocity fields and kinetic turbulence were analyzed based on the simulation results. The analysis shows that the streamlined nozzle achieved the highest flow velocity and lowest turbulent energy at the centerline of the flow field, and should be prioritized in actual applications. The conical-cylindrical nozzle strikes a good balance between efficiency and cost, providing a good option for jetting operations. By contrast, conical nozzle and cylindrical nozzle should not be adopted. The cylindrical segment can stabilize the shape of the jet by increasing the jet acceleration and peak velocity. The nozzle structure should be optimized to reduce the energy loss in each phase of energy conversion, thereby lowering the energy required to destroy a unit volume of the target. The simulation results shed important new light on the selection of nozzle for jetting devices.