Ceramide analogue 14S24 ((S)-2-tetracosanoylamino-3-hydroxypropionic acid tetradecyl ester) is effective in skin barrier repair in vitro

Vávrová, Kateřina; Zbytovská, Jarmila; Palát, Karel; Holas, Tomáš; Klimentová, Jana; Hrabálek, Alexandr; Doležal, Pavel

doi:10.1016/j.ejps.2003.12.009

Cited by 24 publications

(23 citation statements)

References 36 publications

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“…As a result, the skin loses water and becomes dry, cracked and fissured and allows the entrance of allergens, toxins and microorganisms that can inflame and irritate the skin. The inflammation, in return, may cause further disruption of the barrier function, closing the vicious circle [84]. It may also lead to other skin conditions such as severe dryness, itching and scratching that can further lead to secondary skin infections such as herpes, molluscum, warts, staphylococcus, streptococcus, pseudomonas, fungus, yeast and tuberculosis.…”

Section: Skin Diseases and Associated Perturbations Of The Sc Lipid Cmentioning

confidence: 99%

Skin Diseases Associated with the Depletion of Stratum Corneum Lipids and Stratum Corneum Lipid Substitution Therapy

Sahle

Gebre‐Mariam²,

Dobner³

et al. 2014

Skin Pharmacol Physiol

170

164

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The skin is the largest organ of the body, whose main function is to protect the body against the loss of physiologically important components as well as harmful environmental insults. From the inside to the outside, the skin comprises three major structural layers: the hypodermis, the dermis and the epidermis. The epidermis contains four different sublayers, the stratum corneum (SC), stratum granulosum, stratum spinosum and stratum basale, where the barrier function of the skin mainly lies in the outermost layer of the epidermis, the SC. The SC contains corneocytes that are embedded in a lipid matrix existing in the form of lipid bilayers. The lipid bilayers are formed mainly from ceramides, free fatty acids and cholesterol, constitute the only continuous pathway across the SC and are responsible for the barrier function of the skin. However, the depletion or disturbance of SC lipids in the SC leads to a perturbation of the barrier function of the skin, and, conversely, several skin diseases such as psoriasis and atopic dermatitis are associated with the depletion of these SC lipids. Therefore, it is of paramount importance to understand the interrelationship between the depletion of SC lipids and skin diseases as well as factors that affect the composition and organization of SC lipids in order to assess the potential benefit of a direct replacement of the missing SC lipids as a means of treating affected, aged or diseased skin. i 2014 S. Karger AG, Basel

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Section: Skin Diseases and Associated Perturbations Of The Sc Lipid Cmentioning

confidence: 99%

Skin Diseases Associated with the Depletion of Stratum Corneum Lipids and Stratum Corneum Lipid Substitution Therapy

Sahle

Gebre‐Mariam²,

Dobner³

et al. 2014

Skin Pharmacol Physiol

170

164

View full text Add to dashboard Cite

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“…The models of compounds were formed on RHF/AM1 level. We used the conformation of Cer[AP] with parallel aliphatic chains calculated as described previously [31]. Solvent accessible volumes, V SA , of models of studied compounds were calculated by the grid method [32] using the atomic radii of Gavezzotti [33].…”

Section: Molecular Modellingmentioning

confidence: 99%

Influence of cholesterol on the structure of stratum corneum lipid model membrane

Zbytovská

Киселев

Funari³

et al. 2008

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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a b s t r a c tThis study describes the influence of cholesterol on a model membrane consisting of four stratum corneum (SC) lipids in three different states at 32 and 85 • C. Using small-angle X-ray diffraction on multilamellar vesicles, the lamellar repeat distance, D, was determined. Small-angle neutron scattering on unilamellar vesicles was used to calculate the membrane thickness, average area of the membrane surface per molecule, average volume per molecule in the membrane, and membrane density. After the sample preparation, the membranes show one lamellar phase. Over 10 days, the systems separate into two lamellar phases and crystalline cholesterol. On heating the samples to 85 • C, the domains merge into one phase, the D-value of which increases slightly with increasing cholesterol concentration. On cooling the samples back to 32 • C, only one phase is observable again. The increasing cholesterol concentration in the membrane causes a decrease in the D-value, membrane thickness, and membrane density. Simultaneously, the area of the membrane surface and membrane volume per molecule increase. In conclusion, cholesterol fluidises the SC lipid membranes in the state below the main phase transition and condenses above it. This effect can have an important impact on the pathologic skin states such as the recessive X-linked ichthyosis.

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“…This barrier disturbance, which includes a decrease in the water-holding function of the stratum corneum, is attributable to the depletion of intercellular lipids consisting mainly of ceramides (Cer) [11, 12, 13, 14, 15]. Recently, it has been reported that the topical application of Cer or pseudoceramides is effective in repairing cutaneous perturbed barrier function [16, 17, 18, 19, 20, 21]. Surfactant-induced deterioration of the stratum corneum function has been found to occur in parallel with levels of depleted lipids and is reversible by application of mixed intercellular lipids or Cer [9].…”

Section: Introductionmentioning

confidence: 99%

Characterization of Surfactant-Induced Skin Damage through Barrier Recovery Induced by Pseudoacylceramides

Takagi

Nakagawa²,

Higuchi³

et al. 2005

Dermatology

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Background and Objective: To determine how much barrier-reinforcing effects of ceramides contribute to prevent the surfactant-induced cutaneous deterioration. Methods: We compared the effects of topical application of two types of pseudoceramides on cutaneous deterioration induced by sodium dodecyl sulfate (SDS) treatment for 10 days in association with alterations of barrier function. Results: Daily application of pseudoacylceramide immediately after each SDS treatment significantly prevented the marked elevation of transepidermal water loss, which was accompanied by a marked abrogation of the increased expression in intercellular adhesion molecule 1 by epidermal cells as well as by suppressed epidermal hyperplasia. In contrast, topical application of a nonacylated pseudoceramide with poor barrier-reinforcing potential showed less preventive effects on cutaneous deterioration. Conclusion: These results strongly suggest that perturbation of the skin barrier is a causative factor in surfactant-induced cutaneous changes and that reinforcing the barrier function by ceramide application is effective in preventing the surfactant-induced skin deterioration.

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Ceramide analogue 14S24 ((S)-2-tetracosanoylamino-3-hydroxypropionic acid tetradecyl ester) is effective in skin barrier repair in vitro

Cited by 24 publications

References 36 publications

Skin Diseases Associated with the Depletion of Stratum Corneum Lipids and Stratum Corneum Lipid Substitution Therapy

Skin Diseases Associated with the Depletion of Stratum Corneum Lipids and Stratum Corneum Lipid Substitution Therapy

Influence of cholesterol on the structure of stratum corneum lipid model membrane

Characterization of Surfactant-Induced Skin Damage through Barrier Recovery Induced by Pseudoacylceramides

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