Ceramide, cerebroside and triterpenoid saponin from the bark of aerial roots of Ficus elastica (Moraceae)

Abstract

Three compounds, ficusamide (1), ficusoside (2) and elasticoside (3), were isolated from the bark of aerial roots of Ficus elastica (Moraceae), together with nine known compounds, including four triterpenes, three steroids and two aliphatic linear alcohols. The chemical structures of the three compounds were established by extensive 1D and 2D NMR spectroscopy, mass spectrometry and by comparison with published data. The growth inhibitory effect of the crude extract and isolated compounds was evaluated against several microorganisms and fungi. The cytotoxicity against human cancer cell lines was also assessed. Ficusamide (1) displayed a moderate in vitro growth inhibitory activity against the human A549 lung cancer cell line and a strong activity against Staphylococcus saprophyticus, while elasticoside (3) showed a potent activity on Enterococcus faecalis.

Triterpenes from the genus Ficus and Their Bioactivities

“…[22] 3-O-[β-D-glucopyranosyl]-quinovic acid-28-O-[β-L-rhamnopyranosyl] ester (93) was isolated from the aerial roots of F. elastic. [23] Investigation on the EtOH extract of the air dried stems of F. tsiangii afforded 3-acetoxy-12-oleanene-11-ketone (94), 3-acetoxy-lup-12,20(29)-diene (95). [24] Epilupeol acetate (96) was isolated and identified from F. drupacea L with antifungal activities against Aspergillus versicolor and A. ochraceuswere.…”

New ursane triterpenoids from Ficus pandurata and their binding affinity for human cannabinoid and opioid receptors

“…Ficus (Moraceae), which comprises more than 800 species, is a large genus of trees or shrubs cultivated for their ornamental leaves and edible fruits (Metcalf and Chalk 1950; Baily 1963; Lin and Wunder 1997). Plants of the Ficus genus are distributed in tropical and subtropical regions (Mbosso et al 2012) and known to be rich sources of triterpenes and sterols (Tuyen et al 1998; Kuo and Chiang 1999; Ragasa et al 1999; Chiang et al 2001; Chiang and Kuo 2001, 2002; Kuo and Lin 2004; Chiang et al 2005; Sisy and Abeba 2005; Parveen et al 2009). In Ayurvedic and traditional Chinese medicine (TCM), Ficus species are widely used for the treatment of various diseases such as inflammation, diabetes, tumour and malaria (Singh et al 2011).…”

Macro- And Micromorphology of the Leaves, Inflorescences and Fruits of Ficus Sycomorus L. Cultivated in Egypt: Part 1

“…Fruit is syconus formed of an achene within a fleshy receptacle 1&3 . Isoprenoids, steroids, hydrocarbons, flavonoids, coumarins, furocoumarins, lignans, stilbenes, phenylpropanoids, ceramides and alkaloids have been reported as chemical constituents of different Ficus species [4][5][6][7][8][9][10][11] .…”