Ceramide liposomes for skin barrier recovery: A novel formulation based on natural skin lipids

Vovesná, Aneta; Zhigunov, Alexander; Balouch, Martin; Zbytovská, Jarmila

doi:10.1016/j.ijpharm.2021.120264

Cited by 31 publications

(19 citation statements)

References 47 publications

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“…The skin treated with the pure vehicle (aqueous PG without enhancers) showed ν s CH 2 and ν as CH 2 at 2850.72 ± 0.19 and 2919.36 ± 0.33 cm −1 , respectively. These positions correlated with previously published results [48,51,52] and indicated relatively well-ordered lipid chains, with predominant trans-conformations in the SC matrix. Shifts of CH 2 -stretching vibrations to higher positions by 1-2 cm −1 were observed after the skin exposure to the enhancers.…”

Section: The Morpholine Derivatives Interact With Skin Lipidssupporting

confidence: 91%

“…Figure 2 shows the ratios of the skin electrical impedance (EIR), calculated from the EI measured before and after the enhancers' application. The use of this ratio provides a clearer means of expressing the enhancers' influence, without it being hindered by the diversity of the particular skin samples and long hydration times [26,48]. The ratio values for the intact skin control (IND, DF, TH in 60% PG) were set to 1, to emphasise the individual effect of the enhancers according to previous studies [48].…”

Section: The Morpholine Derivatives Reduce Skin Barrier Functionmentioning

confidence: 99%

“…The use of this ratio provides a clearer means of expressing the enhancers' influence, without it being hindered by the diversity of the particular skin samples and long hydration times [26,48]. The ratio values for the intact skin control (IND, DF, TH in 60% PG) were set to 1, to emphasise the individual effect of the enhancers according to previous studies [48]. The main increase in the impedance ratio was achieved by the Mo10, 12 and 14 derivatives.…”

Section: The Morpholine Derivatives Reduce Skin Barrier Functionmentioning

confidence: 99%

“…The longer regenerative time for Mo12 can be related to its intensive enhancing function, causing more notable changes in the SC arrangement. Nevertheless, the skin barrier regeneration might be supported by the addition of a renewing agent into the final formulation [48].…”

Section: Effects Of the Morpholine Derivatives On The Skin Barrier Are Reversiblementioning

confidence: 99%

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N-Alkylmorpholines: Potent Dermal and Transdermal Skin Permeation Enhancers

et al. 2021

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Transdermal drug delivery is an attractive non-invasive method offering numerous advantages over the conventional routes of administration. The main obstacle to drug transport is, however, the powerful skin barrier that needs to be modulated, for example, by transdermal permeation enhancers. Unfortunately, there are still only a few enhancers showing optimum properties including low toxicity and reversibility of enhancing effects. For this reason, we investigated a series of new N-alkylmorpholines with various side chains as potential enhancers in an in vitro permeation study, using three model permeants (theophylline, indomethacin, diclofenac). Moreover, electrical impedance, transepidermal water loss, cellular toxicity and infrared spectroscopy measurements were applied to assess the effect of enhancers on skin integrity, reversibility, toxicity and enhancers’ mode of action, respectively. Our results showed a bell-shaped relationship between the enhancing activity and the hydrocarbon chain length of the N-alkylmorpholines, with the most efficient derivatives having 10–14 carbons for both transdermal and dermal delivery. These structures were even more potent than the unsaturated oleyl derivative. The best results were obtained for indomethacin, where particularly the C10-14 derivatives showed significantly stronger effects than the traditional enhancer Azone. Further experiments revealed reversibility in the enhancing effect, acceptable toxicity and a mode of action based predominantly on interactions with stratum corneum lipids.

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Section: The Morpholine Derivatives Interact With Skin Lipidssupporting

confidence: 91%

Section: The Morpholine Derivatives Reduce Skin Barrier Functionmentioning

confidence: 99%

Section: The Morpholine Derivatives Reduce Skin Barrier Functionmentioning

confidence: 99%

Section: Effects Of the Morpholine Derivatives On The Skin Barrier Are Reversiblementioning

confidence: 99%

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N-Alkylmorpholines: Potent Dermal and Transdermal Skin Permeation Enhancers

et al. 2021

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“…As natural and skin-identical ceramides are expensive, various synthetic pseudo-ceramides have been developed and tested [ 111 , 112 , 113 ] ( Figure 6 ). Various formulations have also been developed to enhance ceramide bioavailability, including those with liposomes and multi-vesicular emulsions [ 104 , 106 , 114 , 115 ]. A recent clinical study showed that a cream or lotion containing ceramides in a multi-vesicular emulsion could sustain skin moisturization longer than commonly used traditional emollients [ 109 ].…”

Section: Potential Therapeutic Approaches To Correct Lipid Abnormalities In Patients With Admentioning

confidence: 99%

The Pathogenic and Therapeutic Implications of Ceramide Abnormalities in Atopic Dermatitis

Fujii

2021

Cells

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Ceramides play an essential role in forming a permeability barrier in the skin. Atopic dermatitis (AD) is a common chronic skin disease associated with skin barrier dysfunction and immunological abnormalities. In patients with AD, the amount and composition of ceramides in the stratum corneum are altered. This suggests that ceramide abnormalities are involved in the pathogenesis of AD. The mechanism underlying lipid abnormalities in AD has not yet been fully elucidated, but the involvement of Th2 and Th1 cytokines is implicated. Ceramide-dominant emollients have beneficial effects on skin barrier function; thus, they have been approved as an adjunctive barrier repair agent for AD. This review summarizes the current understanding of the mechanisms of ceramide abnormalities in AD. Furthermore, the potential therapeutic approaches for correcting ceramide abnormalities in AD are discussed.

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