Ceramide ratios are affected by cigarette smoke but not heat-not-burn or e-vapor aerosols across four independent mouse studies

Lavrynenko, Oksana; Titz, Bjoern; Dijon, Sophie; Santos, Daniel dos; Nury, Catherine; Schneider, Thomas; Guedj, Emmanuel; Szostak, Justyna; Kondylis, Athanasios; Phillips, Blaine; Ekroos, Kim; Martin, Florian; Peitsch, Manuel C.; Hoeng, Julia; Ivanov, Nikolai V.

doi:10.1016/j.lfs.2020.118753

Cited by 15 publications

(6 citation statements)

References 77 publications

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“…Also, the detrimental effect continued even during smoking cessation, which is consistent with the irreversibility presented in our study. Animal experiments also confirmed the changed ratio of Cer(d18:1/24:0) to Cer(d18:1/18:0) as markers of CS exposure in the lungs, plasma, and liver (54). As the metabolites of sphingolipids, ceramides are considered as lipotoxic inducers of disturbed glucose homeostasis and also an active player in the progression of atherosclerosis (55).…”

Section: Discussionmentioning

confidence: 72%

Impacts of Cigarette Smoking Status on Metabolomic and Gut Microbiota Profile in Male Patients With Coronary Artery Disease: A Multi-Omics Study

Fan

et al. 2021

Front. Cardiovasc. Med.

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Background: Cigarette smoking has been considered a modifiable risk factor for coronary artery disease (CAD). Changes in gut microbiota and microbe-derived metabolites have been shown to influence atherosclerotic pathogenesis. However, the effect of cigarette smoking on the gut microbiome and serum metabolites in CAD remains unclear.Method: We profiled the gut microbiota and serum metabolites of 113 male participants with diagnosed CAD including 46 current smokers, 34 former smokers, and 33 never smokers by 16S ribosomal RNA (rRNA) gene sequencing and untargeted metabolomics study. A follow-up study was conducted. PICRUSt2 was used for metagenomic functional prediction of important bacterial taxa.Results: In the analysis of the microbial composition, the current smokers were characterized with depleted Bifidobacterium catenulatum, Akkermansia muciniphila, and enriched Enterococcus faecium, Haemophilus parainfluenzae compared with the former and never smokers. In the untargeted serum metabolomic study, we observed and annotated 304 discriminant metabolites, uniquely including ceramides, acyl carnitines, and glycerophospholipids. Pathway analysis revealed a significantly changed sphingolipids metabolism related to cigarette smoking. However, the change of the majority of the discriminant metabolites is possibly reversible after smoking cessation. While performing PICRUSt2 metagenomic prediction, several key enzymes (wbpA, nadM) were identified to possibly explain the cross talk between gut microbiota and metabolomic changes associated with smoking. Moreover, the multi-omics analysis revealed that specific changes in bacterial taxa were associated with disease severity or outcomes by mediating metabolites such as glycerophospholipids.Conclusions: Our results indicated that both the gut microbiota composition and metabolomic profile of current smokers are different from that of never smokers. The present study may provide new insights into understanding the heterogenic influences of cigarette smoking on atherosclerotic pathogenesis by modulating gut microbiota as well as circulating metabolites.

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Section: Discussionmentioning

confidence: 72%

Impacts of Cigarette Smoking Status on Metabolomic and Gut Microbiota Profile in Male Patients With Coronary Artery Disease: A Multi-Omics Study

Fan

et al. 2021

Front. Cardiovasc. Med.

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“…Results from the Systems Toxicology Assessment of tissues obtained from the majority of the studies conducted by PMI have indicated a significantly lower response in terms of gene, microRNA and/or protein expression as a result of exposure to experimentally generated aerosols from heated tobacco products compared to exposure to mainstream smoke from the 3R4F Kentucky Reference cigarette (Kogel et al, 2016;Elamin et al, 2016;Lo Sasso et al, 2016a;Szostak et al, 2017Szostak et al, , 2020Choukrallah et al, 2019;2020;Lavrynenko et al, 2020;Titz et al, 2020b;van der Plas et al, 2020).…”

Section: Chronic Rodent Exposure Studiesmentioning

confidence: 99%

The product science of electrically heated tobacco products: a narrative review of the scientific literature

Malt

Thompson²,

Mason

et al. 2022

F1000Res

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Heated tobacco products represent a novel category of tobacco products in which a tobacco consumable is heated to a temperature that releases nicotine from the tobacco leaf but not to a temperature sufficient to cause combustion. Heated tobacco products may therefore have the potential to be a less harmful alternative for adult smokers that would otherwise continue to smoke conventional cigarettes. Given the rapid development of this product category, the aim of this review was to examine the available peer-reviewed scientific evidence related to heated tobacco products and highlight any research gaps. In recent years, manufacturers of heated tobacco products have published a number of studies on their respective heated tobacco products. Whilst there is limited research that is independent of commercial interests, the available scientific evidence indicates that heated tobacco products produce a much simpler aerosol than conventional cigarette smoke, with fewer and substantially lower levels of harmful toxicants. Toxicology assessments indicate these reductions in aerosol toxicants translate to reduced biological effects. Biomarker and clinical data from studies in which product use is controlled within a clinical setting, indicate changes in biomarker levels and clinical end-points similar to observations in cessation studies, indicating the potential for reduced harm. The scientific evidence also indicates that exposure of non-users to emissions from heated tobacco products in indoor environments is significantly reduced compared to exposure resulting from smoking conventional cigarettes. Overall, the available scientific evidence indicates that heated tobacco products hold promise as a less harmful alternative to conventional cigarettes, but more independent data is required to validate industry findings. As a growing product category, epidemiological studies and independent population modelling studies are outstanding, and empirical data on how dual tobacco product category use by consumers affects their risk profile is lacking.

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“…Воздействие сигаретного дыма в течение 3 мес. приводило к значительному повышению отношения C(d18:1/24:0) и C(d18:1/24:1) к C(d18:1/18:0) в плазме, печени, легких и брюшной аорте мышей [60].…”

Section: курениеunclassified

Ceramides: correlation with cardiovascular risk factors

Белик

Dyleva

Груздева

2022

SJCEM

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Despite the successes achieved, cardiovascular disease (CVD) remains the leading cause of death worldwide. With the help of traditional risk factors, it is not always possible to identify all patients with a high probability of developing cardiovascular events (CVЕ); therefore, the problem of finding new CVD biomarkers still remains relevant. Previous studies have shown the important role of excessive synthesis of ceramides in the development of obesity, insulin resistance (IR), type 2 diabetes mellitus (DM2), and liver steatosis. It is considered that ceramides are able to modulate signaling pathways involved in the regulation of glucose metabolism, triglyceride synthesis, development of apoptosis, fibrosis, and atherosclerosis. Given the wide range of metabolic effects, the study of ceramides is promising for identifying patients at high risk of CVD, as well as improving existing treatment and diagnostic strategies. This review article considers the role of ceramides in the development of atherosclerosis, the correlation with traditional risk factors, and the possibility of using them as new risk factors for early diagnosis of CVD.

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Ceramide ratios are affected by cigarette smoke but not heat-not-burn or e-vapor aerosols across four independent mouse studies

Cited by 15 publications

References 77 publications

Impacts of Cigarette Smoking Status on Metabolomic and Gut Microbiota Profile in Male Patients With Coronary Artery Disease: A Multi-Omics Study

Impacts of Cigarette Smoking Status on Metabolomic and Gut Microbiota Profile in Male Patients With Coronary Artery Disease: A Multi-Omics Study

The product science of electrically heated tobacco products: a narrative review of the scientific literature

Ceramides: correlation with cardiovascular risk factors

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