Ceratocarpus arenarius: Botanical Characteristics, Proximate, Mineral Composition, and Cytotoxic Activity

Kantureyeva, Aigerim; Ustenova, Gulbaram; Zvonar Pobirk, Alenka; Mombekov, Serzhan; Koilybayeva, Moldir; Amirkhanova, Akerke; Gemejiyeva, Nadezhda; Mamurova, Assem; Kočevar Glavač, Nina

doi:10.3390/molecules29020384

Cited by 2 publications

(2 citation statements)

References 27 publications

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“…For example, the high content of linoleic acid indicates that the sample may be a good source of essential fatty acids, which have health benefits, including reducing the risk of heart disease and improving brain function. A complex of fatty acids and the strongest natural antioxidants, are necessary for all people for daily intake, strengthening the body, and increasing its energy and vitality [23].…”

Section: Discussionmentioning

confidence: 99%

Study of the chemical components of CO2 extracts from the fruits of Sorbus aucuparia L.

Mombekov,

Datkhayev,

Kalamkul

et al. 2024

ScienceRise: Pharmaceutical Science

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The article presents the results of the study of the chemical composition of Sorbus aucuparia L. СО2 subcritical extract. For the first time in Kazakhstan, 20 grams of brown Sorbus aucuparia L. extract were collected using subcritical carbon dioxide extraction. The current study was directed mainly to the chemical compositions of subcritical Sorbus aucuparia L. СО2 subcritical extract. The Sorbus aucuparia L. extract's chemical compositions were determined using gas chromatography/mass spectrophotometry (GC-MS). The extract included the following main compounds: 5-Methyl-2(3H)-furanone (30.18 %), 5-(3-Ethoxy-4,5-dihydro-isoxazol-5-yl)-5-methyl-imidazolidine-2,4-dione (3.20 %), 4H-Pyran-4-one, 2,3-dihydro-3,5-dihydroxy-6-methyl (2.53 %). Determined fatty acid profile and the moisture content of raw vegetable ingredients of Sorbus substance. Quantitative determination of fatty acids of ethanol extract was carried out. The results of the analysis for fatty acids in the study showed that linoleic (37.7 %) and oleic (50.5 %) were the most prominent fatty acids. The aim of this study is to determine the component composition by using the GC-MS method and fatty acid to study the Sorbus aucuparia L. extract obtained by CO2 extraction, which grows in Kazakhstan. Materials and methods. To determine the possibility of using Sorbus aucuparia L., we carried out the composition and fatty acid of the extract obtained by CO2 extraction in subcritical conditions of Sorbus aucuparia L. by a certain GC-MS method. Results. The raw materials of the plant were collected in accordance with GACP requirements. Conducted subcritical CO2 extraction of plant raw materials showed a 20 g extraction yield. Chemical compounds were discovered, bioactive components were identified, such as 5-Methyl-2(3H)-furanone (30.18 %), 5-(3-Ethoxy-4,5-dihydro-isoxazol-5-yl)-5-methyl-imidazolidine-2,4-dione (3.20 %), 4H-Pyran-4-one, 2,3-dihydro-3,5-dihydroxy-6-methyl (2.53 %). Conclusions. The possibility of using the obtained CO2 extract of Sorbus aucuparia L. in the field of pharmaceutical products as a substance and a drug

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Section: Discussionmentioning

confidence: 99%

Study of the chemical components of CO2 extracts from the fruits of Sorbus aucuparia L.

Mombekov,

Datkhayev,

Kalamkul

et al. 2024

ScienceRise: Pharmaceutical Science

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“…Particularly, omega fat acid groups, which the body can only acquire externally, are crucial for the functioning of the cardiovascular system [22].…”

Section: Discussionmentioning

confidence: 99%

Development of antifungal gel, composition and technology based on pomiferin metabolite isolated from fruits of Maclura aurantiaca growing in Kazakhstan

Mombekov,

Orazbekov,

Sadykova

et al. 2024

SR: PS

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The aim. The purpose of this study is to develop the optimal composition and rational gel technology under the conventional name "Kaz-P7" based on the antifungal pomiferin. Materials and methods. The object of the study is the substance pomiferin. Based on the physicochemical properties of the gel (poorly soluble in water) and technological properties structurant - Carbopol Ultrez 20 (swelling) chosen optimal solvent system: DMSO-PG-water (1:4:1) corresponding to the maximum solubility of drug and polymer provides swelling. Following the requirements of GF RK I, vol. 1, 2.2.8, 2.2.10 was determined by rotational viscometric method. Rheological properties of the sample are determined using rotational viscometer "Rheolab QC" (firm "Anton Paar", Austria) with coaxial cylinders CC27/S-SN29766 determined. The rheological parameters were studied at a temperature of 20 °C – 35 °C using the MLM U15c thermostat included in the rheostat. Results. Gel dosage forms provide better bioavailability of the drug substance. In addition, gels are a more modern dosage form, pleasant in terms of organoleptic characteristics. The technology of gel manufacturing consists of two parallel processes: preparation of the drug substance solution and its introduction into the base. From the point of view of biopharmacy, which studies the biological effect of drugs depending on their physical properties, dosage form and preparation technology, the greatest release of the drug substance occurs when it is introduced into the dosage form in dissolved form. Pomiferin administered in the dissolved state has the most therapeutic effect on the gel base. At the same time, active pharmaceutical ingredients (APIs) were dissolved in different solvents with gradual heating. The ratio of solvents DMSO-PG-water (1:4:1) at which the developed dosage form will be more structured, stable, and thixotropic gel is established. Conclusions. Fungal skin diseases are among the most frequently discussed problems in the literature. The relevance of this topic is determined by the high prevalence of pathogens, which account for 37-42 % of all skin diseases. It was experimentally established that for the complete neutralization of one gm of carbopol Ultraz 20 in the DMSO-PG-water solvent system (1:4:1), one gm of triethanolamine (pH 7.0) is consumed. The optimal diluent consisting of DMSO-PG- water in the ratio (1:4:1) was selected by physico-chemical analysis methods, and one gm of triethanolamine (pH 7.0) was selected as the neutralizing agent. The following composition was chosen as the optimal gel model: API-3.0, DMSO-3.0, PG-50.0, Carbopol Ultrez 20-1.0, and Triethanolamine-1.0. The optimal composition and technology of the gel codenamed "Kaz-P7" based on the substance obtained by pomiferin was developed

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Ceratocarpus arenarius: Botanical Characteristics, Proximate, Mineral Composition, and Cytotoxic Activity

Cited by 2 publications

References 27 publications

Study of the chemical components of CO2 extracts from the fruits of Sorbus aucuparia L.

Study of the chemical components of CO2 extracts from the fruits of Sorbus aucuparia L.

Development of antifungal gel, composition and technology based on pomiferin metabolite isolated from fruits of Maclura aurantiaca growing in Kazakhstan

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