Cerebellar Contributions to Language in Typical and Atypical Development: A Review

Vias, Carolina; Dick, Anthony Steven

doi:10.1080/87565641.2017.1334783

Cited by 45 publications

(31 citation statements)

References 78 publications

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“…First, this may not be a direct association (i.e., more total sedentary time), but an indirect influence (lower physical activity levels) affecting the key role that the cerebellum has in motor control and movement [43][44][45]. Second, the importance of the cerebellum for intelligence has been previously reported in some populations, and the specific association with crystallized, rather than fluid, intelligence may be supported by previous functional imaging studies showing cerebellar activation in relation to language, attention and mental imagery [46][47][48]. However, in the present study we showed structural, but not functional, brain correlates of sedentary behaviors, and all these speculations about links with intelligence should be viewed with caution.…”

Section: Discussionmentioning

confidence: 60%

Association of Sedentary Behavior with Brain Structure and Intelligence in Children with Overweight or Obesity: The ActiveBrains Project

Zavala-Crichton

Esteban‐Cornejo

Solis‐Urra

et al. 2020

JCM

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We investigated the associations of different sedentary behaviors (SB) with gray matter volume and we tested whether SB related to gray matter volume is associated with intelligence. Methods: 99 children with overweight or obesity aged 8–11 years participated in this cross-sectional study. SB was measured using the Youth Activity Profile-Spain questionnaire. T1-weighted images were acquired with a 3.0 T Magnetom Tim Trio system. Intelligence was assessed with the Kaufman Brief Test. Whole-brain voxel-wise multiple regression models were used to test the associations of each SB with gray matter volume. Results: Watching TV was associated with lower gray matter volume in six brain regions (β ranging −0.314 to −0.489 and cluster size 106 to 323 voxels; p < 0.001), playing video games in three brain regions (β ranging −0.391 to −0.359, and cluster size 96 to 461 voxels; p < 0.001) and total sedentary time in two brain regions (β ranging −0.341 to −0.352, and cluster size 897 to 2455 voxels; p < 0.001). No brain regions showed a significant positive association (all p > 0.05). Two brain regions were related, or borderline related, to intelligence. Conclusions: SB could have the potential to negatively influence brain structure and, in turn, intelligence in children with overweight/obesity.

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Section: Discussionmentioning

confidence: 60%

Association of Sedentary Behavior with Brain Structure and Intelligence in Children with Overweight or Obesity: The ActiveBrains Project

Zavala-Crichton

Esteban‐Cornejo

Solis‐Urra

et al. 2020

JCM

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“…The co-activation patterns of lobule VI suggest that it also contributes to cognitive aspects of language processes together with frontoparietal regions (Stoodley et al, 2012;Vias and Dick, 2017). The inferior parietal lobe (IPL) and S1 (area 2) are tightly interconnected (Borich et al, 2015) and serve as an interface to process proprioceptive signals and body-related information (Prevosto et al, 2011;Tsakiris et al, 2007).…”

Section: Enhanced Dai Connectivity In Singers Versus Non-singersmentioning

confidence: 99%

Singing training predicts increased insula connectivity with speech and respiratory sensorimotor areas at rest

Zamorano

Zatorre

Vuust

et al. 2019

Preprint

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The insula contributes to the detection and integration of salient events during goaldirected behavior and facilitates the interaction between motor, multisensory, and cognitive networks. Task-fMRI studies have suggested that experience with singing can enhance access to these resources. However, the long-term effects of vocal motor training on insula-based networks are currently unknown. In this study, we used restingstate fMRI to explore experience-dependent differences in insula co-activation patterns between conservatory-trained singers and non-singers. We found enhanced insula connectivity in singers compared to non-singers with constituents of the speech sensorimotor network, including the cerebellum (lobule VI, crus 2), primary somatosensory cortex, the parietal lobes, and the thalamus. Moreover, accumulated singing training correlated positively with increased co-activation in bilateral primary sensorimotor cortices in the somatotopic representations of the larynx (left dorsal anterior insula, dAI) and the diaphragm (bilateral dAI)-crucial regions for motorcortical control of complex vocalizations-together with the thalamus (bilateral posterior insula/left dAI) and the left putamen (left dAI). The results of this study support the view that the insula plays a central role in the experience-dependent modulation of sensory integration within the vocal motor system, possibly by optimizing conscious and non-conscious aspects of salience processing associated with singing-related bodily signals.

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“…The thalamus functions as a sort of relay center to connect many brain areas involved in language processing (Wahl et al, 2008;Murdoch, 2010;David et al, 2011) and changes in the thalamus have been claimed to contribute to the evolutionary emergence of our language-ready brain (see Boeckx and Benítez-Burraco, 214a for details). Similarly, the cerebellum plays a key role in language processing and is impaired in language-related pathologies (Vias and Dick, 2017;Mariën and Borgatti 2018). People with WS exhibit cerebellar volume alterations that are seemingly associated with their cognitive, affective and motor distinctive features (Osório et al, 2014).…”

Section: Resultsmentioning

confidence: 99%

Robust candidates for language development and evolution are significantly dysregulated in the blood of people with Williams syndrome

Benítez‐Burraco

Kimura

2018

Preprint

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Williams syndrome (WS) is a clinical condition entailing cognitive deficits and with an uneven language profile, which has been object of intense inquiry over the last decades. Although WS results from the hemideletion of around two dozens of genes in chromosome 7, no gene has been yet probed to account for, or contribute significantly to, the language problems exhibited by the affected people. In this paper we show that robust candidates for language disorder and for language evolution in the species, located outside the hemideleted region, are up-or downregulated in the blood of subjects with WS. Most of these genes play a role in the development and function of brain areas involved in language processing, which exhibit structural and functional anomalies in people with the condition. Overall, these genes emerge as robust candidates for language dysfunction in WS.

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Cerebellar Contributions to Language in Typical and Atypical Development: A Review

Cited by 45 publications

References 78 publications

Association of Sedentary Behavior with Brain Structure and Intelligence in Children with Overweight or Obesity: The ActiveBrains Project

Association of Sedentary Behavior with Brain Structure and Intelligence in Children with Overweight or Obesity: The ActiveBrains Project

Singing training predicts increased insula connectivity with speech and respiratory sensorimotor areas at rest

Robust candidates for language development and evolution are significantly dysregulated in the blood of people with Williams syndrome

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