Cerebellar involvement in classical Hodgkin’s lymphoma: A case report

Abstract

Intracranial involvement of Hodgkin’s lymphoma is rare, occurring in less than 0.5% of all cases, and usually reported as case reports. Most cases of intracranial involvement are observed at the time of relapse and are associated with poor clinical outcomes. We report the case of a 21-year-old male patient with previously treated Stage IV classical Hodgkin’s lymphoma with cerebellar metastasis. The patient had refractory disease and presented with a headache. On evaluation, he was found to have cerebellar lesions and extracranial disease. He received palliative chemotherapy with bendamustine and lenalidomide, followed by whole-brain radiotherapy. To add to the available literature, we report the case that highlights the limited treatment options for central nervous system (CNS) Hodgkin’s lymphoma, where salvage chemotherapy and whole-brain radiotherapy yield transient responses.