Cerebellar Liponeurocytoma: A Novel Report from Nigeria in a 6-Year-Old Girl, and Review of Literature

Abstract

Liponeurocytoma is a newly defined clinical entity predominantly seen in the cerebellum as a slow-growing tumor. In this report, we present the case of a 6-year-old Nigerian girl with a liponeurocytoma, and review of literature.

Cerebellar Liponeurocytoma Mimicking Medulloblastoma: Case Report of a Childhood and Literature Review

“…In the case reported by Cai et al, a cLNC in the right frontal lobe was completely resected and no recurrence was observed at 6 years and 2 months after the initial total tumor resection ( 11 ). This was also true for the case reported by Nzegwu et al who also only received GTR ( 13 ). Regarding patients with incomplete tumor resection (ITR) and/or a high Ki-67 index, postoperative radiotherapy is strongly recommended ( 23 ).…”

“…Based on these studies, some researchers had given advice to replace the term ‘cerebellar liponeurocytoma’ into ‘central liponeurocytoma’, or solely as ‘liponeurocytoma’ ( 16 – 18 ). In all four pediatric patients with liponeurocytoma, including the case reported here, the onset location included the 4 th ventricle and cerebellar vermis (2/4) ( 12 ), left cerebellar hemisphere (1/4) ( 13 ), and right frontal lobe (1/4) ( 11 ). The onset age of juvenile patients in two females and two males was 4-11 years, with a mean age of 6.75 years.…”

“…When reviewing all publications involving cLNCs that were retrieved from PubMed, only 66 cases were found, and almost all of them were sporadic cases. cLNCs in children are extremely rare, with only 3 reported cases ( 11 – 13 ). We herein present a case of cLNC located in the 4 th ventricle and cerebellar vermis of a 5-year-old boy and summarized all the reported cLNCs developed in juveniles.…”

“…al. who also only received GTR(13). Regarding patients with incomplete tumor resection (ITR) and/ or a high Ki-67 index, postoperative radiotherapy is strongly recommended(23).…”

Surgical management and clinical outcomes of cerebellar liponeurocytomas-a report of 7 cases and a pooled analysis of individual patient data

“…There is no signi cant gender predominance for CLPN in this study, however, for supratentorial liponeurocytoma, the male-to-female ratio was 3:1, with an obvious male predilection, for infratentorial liponeurocytoma, the male-to-female ratio was 2.4:3.8, with a female predilection. The brain tumor often affected adults and occasionally involved children, only 2 patients below 20 years old were reported previously [14,47]. The tumors were usually solitary, but multifocal lesions were also reported [34,54,60,61].…”