Cerebellar Liponeurocytoma: A Rare Fatty Tumor and its Literature Review

Abstract

Cerebellar liponeurocytoma is a rare oncological entity, and the knowledge about the treatment and outcome of these rare tumors is still evolving. Very few cases have been described in literature. We report a middle-aged male who presented with raised intracranial pressure features and gait ataxia. His imaging features revealed classical features of liponeurocytoma in cerebellar vermis, with abundant fat component evident in both computed tomography and magnetic resonance imaging. He underwent resection of the lesion and has been asymptomatic for 4 years. This report describes the classical radiological and immunohistochemical features of this rare entity with favorable outcome and reviews the existing literature.

Surgical management and clinical outcomes of cerebellar liponeurocytomas-a report of 7 cases and a pooled analysis of individual patient data

“…We speculate that GTR could prevent the early recurrence of CLPN but had limited bene t on its long-term recurrence. Some studies believe that postoperative radiotherapy decrease the tumor recurrence [21,27], but of our pooled analysis, there is no statistical difference of tumor recurrence with or without radiotherapy. Kaplan-Meier curve also showed that Radiotherapy did not signi cantly prolonged PFS.…”

“…However, recurrence of CLPN is relatively high, available 64 cases (including 57 cases from the literature and 7 cases from our institute), 17 cases (26.6%) suffered tumor recurrence. In previous studies, optimum treatment modality was considered to be totally surgical resection [21]. We performed a multivariate Cox analysis and the results revealed that GTR had signi cantly prolonged PFS (p=0.030).…”

“…The fat in CLPN can be observed on CT as a hypodense lesion. MRI imaging usually shows a hyperintense signal on T1WI and the signal often get inverted in fat-suppressed images [21]. According to previous studies, 11 C-methionine in positron emission tomography (Met-PET) showed that Met uptake values were relatively high (Tmax/Nave: 3.2, 2.7), which may help establish a preoperative diagnosis of CLPN [34,64].…”

Cerebellar Liponeurocytoma Mimicking Medulloblastoma: Case Report of a Childhood and Literature Review

“…The differential diagnosis includes medulloblastoma, oligodendroglioma, ependymoma, and central neurocytoma among others, especially for pediatric patients (7,(32)(33)(34)(35).…”

“…Medulloblastoma always shows foamy histiocytes, primitive neuroectodermal cells, a high mitotic rate, and a high Ki-67 index (9,34,36). Moreover, isochromosome 17q, a genetic hallmark that is present in 40% of classic medulloblastomas, has never been observed in any of the cLNCs (36).…”