Cerebellar liponeurocytoma with atypical histological features – a rare example of a glioneuronal tumor

Abstract

A b s t r a c tWe present a case of a rare neoplasm in a 77-year-old

Typical Radiological Features of a Rare Lateral Ventricular Liponeurocytoma

“…Immunophenotyping is an important tool for differential diagnosis in liponeurocytoma, where neurocytic and vacuolated cells show neuronal differentiation (synaptophysin, NSE). 5 Other different staining has also been found in reported cases which demonstrate neuronally specialized differentiation. 3 A combination of complete resection and radiation therapy may lower the recurrence of this rare tumor.…”

“…Histopathologically, the neoplasm is composed of isomorphic, neurocytic cells and focal lipomatous differentiation. Immunophenotyping is an important tool for differential diagnosis in liponeurocytoma, where neurocytic and vacuolated cells show neuronal differentiation (synaptophysin, NSE) 5 . Other different staining has also been found in reported cases which demonstrate neuronally specialized differentiation 3 .…”

Cerebellar Liponeurocytoma Mimicking Medulloblastoma: Case Report of a Childhood and Literature Review

“…Immunostaining provides additional meaningful information that allows for correct diagnosis and differential diagnosis. cLNCs immunohistochemical analyses were positive for SYN, GFAP, NSE, and MAP-2, and negative for IDH-1 mutations, oligo-2, and EMA (10,11,23,31). In addition, enhanced levels of the adipocyte-associated transcription factor, NEUROG1, and fatty acid-binding protein 4, have been described in cLNCs (14).…”

“…Notably, mild to moderate peritumoral edema was observed in three pediatric patients (3/ 4), with two cases of mild, and one case of moderate surrounding edema. However, peritumoral edema was observed only in 9 adult patients (9/63, [14.3%]) (16,(23)(24)(25)(26)(27)(28)(29)(30), as was mild edema. In some studies, the metabolic activity of cLNCs was evaluated with positron emission tomography (PET) (7,31).…”

“…who also only received GTR(13). Regarding patients with incomplete tumor resection (ITR) and/ or a high Ki-67 index, postoperative radiotherapy is strongly recommended(23).…”