Cerebellar Malignant Fibrous Histiocytoma: Case Report and Literature Review

Hamlat, Abderrahmane; Adn, Mahmoudreza; Caulet‐Maugendre, Sylvie; Guegan, Y

doi:10.1227/01.neu.0000108982.26949.f7

Cited by 9 publications

(11 citation statements)

References 53 publications

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“…Hamlat et al, presented 49 reported intracranial pleomorphic sarcomas [8]. They found that UPS may occur at any age and with no sex predominance.…”

Section: Discussionmentioning

confidence: 99%

“…It would, therefore, seem logical that adjuvant radiotherapy would demonstrate a survival benefit; however, the optimal dose has not yet been proven. Even with aggressive chemotherapy and radiation, median survival was only 27 months due to local progression with occasional metastasis and cerebrospinal fluid dissemination according to Hamlat et al’s series [8]. Doxorubicin and ifosfamide have been used in the treatment of intracranial UPS due to their activity against soft tissue sarcomas as reported by Akimoto et al [9].…”

Section: Discussionmentioning

confidence: 99%

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Intraventricular Undifferentiated Pleomorphic Sarcoma: A Case Report

Sieg¹,

Stepanyan²,

Payne³

et al. 2016

Cureus

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Undifferentiated pleomorphic sarcoma is a histologic diagnosis based on cell morphology. These tumors are found throughout the body. They are rarely found in the central nervous system and almost never occur as a primary intraventricular tumor. We present the unusual case of a 68-year-old woman with an intraventricular undifferentiated pleomorphic sarcoma. We go on to discuss the clinical presentation, radiographic characteristics, and management paradigm for these rare lesions. Our patient presented with acute confusion, inability to balance a checkbook, and gait imbalance. CT and MRI demonstrated a 4 x 3.6 x 3.6 cm enhancing lesion in the left lateral ventricle abutting the foramen of Monro. Pathology revealed an undifferentiated pleomorphic sarcoma.

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“…Hamlat et al, presented 49 reported intracranial pleomorphic sarcomas [8]. They found that UPS may occur at any age and with no sex predominance.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Intraventricular Undifferentiated Pleomorphic Sarcoma: A Case Report

Sieg¹,

Stepanyan²,

Payne³

et al. 2016

Cureus

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“…MFHs account for 10.5%-21.6% of all malignant neoplasias of soft tissue [20] . MFHs in the central nervous system are extremely rare, but have been reported in the brain, dura mater, and spine [5] . Some MFHs arising from the skull bones or subcutaneous tissues can also extend into the cranial cavity [21][22][23] .…”

Section: Discussionmentioning

confidence: 99%

“…In 2004, Hamlat et al [5] performed a complete review of intracranial MFH reports published before 2003.…”

Section: Literature Review and Survival Analysismentioning

confidence: 99%

Clinical Features and Prognostic Factors of Primary Intracranial Malignant Fibrous Histiocytoma: A Report of 8 Cases and a Literature Review

Zhou

Yang

Wang

et al. 2016

Translational Neuroscience and Clinics

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Objective Primary intracranial malignant fibrous histiocytoma (MFH) is rare. We describe the detailed clinical features of 8 cases and fully review the literature to evaluate several prognostic factors. Methods Eight patients with pathologically confirmed primary intracranial MFH were retrospectively reviewed. We searched PubMed for relevant articles with the term “intracranial malignant fibrous histiocytoma”. Results Of the 8 patients, 4 were men and 4 were women. Three patients had received previous radiotherapy. The age of the patients ranged from 19 to 69 years, with a median age of 48 years. Most tumors could be totally resected; and only 1 tumor was subtotally resected. Six patients received postoperative radiotherapy and 3 patients received postoperative chemotherapy. Most patients died within the first year after surgery; and only 1 patient was still alive on the date of the last follow-up. We reviewed the literature and included a total of 46 patients in the Kaplan-Meier survival analysis. Young patients (less than 30 years old) seemed to have a better prognosis and survival rate than older patients (more than 30 years old) (log-rank test, P = 0.008). However, sex (P = 0.675), extent of resection (P = 0.934), postoperative radiotherapy (P = 0.592), and postoperative chemotherapy (P = 0.424) did not affect patient prognosis. Conclusions The prognosis of MFH is usually poor, and most patients die within the first year after surgery. Younger MFH patients (less than 30 years old) seem to have a better prognosis and improved survival compared to older patients.

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“…Brain metastases arise in less than 0.2% of patients with systemic soft tissue sarcomas, but may be more frequent in patients with systemic MFH (4 out of 40 cases in one large case series) [2]. MFH can rarely arise primarily within the CNS and take cystic forms [3]. MFH has been reported to arise within the heart and produce multiple cerebral metastases [4].…”

Section: Discussionmentioning

confidence: 99%

Metastatic cerebral malignant fibrous histiocytoma masquerading as neurocysticercosis

2011

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Malignant fibrous histiocytoma (MFH) is one of the most common subtypes of the pleomorphic sarcomas. It has rarely been reported to metastasize to the brain and even less often to manifest as cystic brain lesions. We report an unusual case of MFH occurring in the aorta and presenting as multiple cystic brain lesions and peripheral blood eosinophilia. The combination of eosinophilia and multiple cystic brain lesions in a patient from an area of the world endemic for Taenia solium suggested the more common diagnosis of neurocysticercosis. However the patient's clinical course and subsequent investigations revealed the very rare combination of features (aortic origin, eosinophilia induction, and multiple cystic brain metastases) of this unusual tumor. Case ReportA 56-year-old male from South America presented with right sided weakness that had developed slowly over the course of 2 days. Blood work revealed a normal white count (8.8 9 10 9 cells/dl) with eosinophilia (8.0%). Head CT revealed multiple cystic lesions throughout the brain parenchyma, some with surrounding edema (see Fig. 1a). MRI showed multiple cystic ring-enhancing lesions, some with surrounding edema. No scolix were identified, however one cyst had necrotic material within it. Due to the systemic eosinophilia and the patient residing in an endemic region, neurocysticercosis was suspected. Serum antibody for Taenia antigens was negative. CT of the chest abdomen and pelvis was initially normal, but transesophageal echocardiography revealed a large, mobile, irregularly shaped mass with echo free spaces in the aorta which appeared to extend into the left subclavian artery (see Fig. 1b). This was confirmed by aortic MRA (see Fig. 1c). During the course of these investigations (15 days), the patient developed new onset left sided weakness, and was found to have new cerebral lesions. Brain biopsy performed 23 days after initial presentation revealed pleomorphic cells with variable size and shapes, some cells with lymphocytic and histiocytic features in an angiocentric distribution (see Supplementary Figure). These cells invariably stained positive for vimentin and KP-1 (a CD68 histiocytic marker), and variably for CD30 and Alk-1. A TEE done 2 months after the initial one showed that the mass had increased in size and filled the distal aortic arch. There was also a new large mass in the posterior atrioventricular groove near the left atrium which invaded the left atrial free wall and entered the left atrial cavity. At this time, the patient had developed a new mass in his trapezius muscle which was biopsied and showed large, Electronic supplementary material The online version of this article (

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Cerebellar Malignant Fibrous Histiocytoma: Case Report and Literature Review

Cited by 9 publications

References 53 publications

Intraventricular Undifferentiated Pleomorphic Sarcoma: A Case Report

Intraventricular Undifferentiated Pleomorphic Sarcoma: A Case Report

Clinical Features and Prognostic Factors of Primary Intracranial Malignant Fibrous Histiocytoma: A Report of 8 Cases and a Literature Review

Metastatic cerebral malignant fibrous histiocytoma masquerading as neurocysticercosis

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