Cerebellar Metastasis as First Metastasis from Papillary Thyroid Carcinoma

Pazaitou‐Panayiotou, Kalliopi; Kaprara, Athina; Chrisoulidou, Alexandra; Boudina, Maria; Georgiou, Eleni; Patakiouta, Frideriki; Drimonitis, Apostolos; Vainas, Iraklis

doi:10.1507/endocrj.52.653

Cited by 35 publications

(28 citation statements)

References 19 publications

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“…17) However, brain metastasis from thyroid carcinoma is rare, occurring in only 0.1% to 5% of cases in reported series. 1,2,6,7,12,16) Metastasis of thyroid carcinoma to the cerebellopontine angle is even rarer, with only three such reports. 1,2,5,6) Hemorrhagic brain metastases can occur in the context of melanoma, choriocarcinoma, renal cell carcinoma, and bronchogenic carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Cerebellar Hemorrhage Secondary to Cerebellopontine Angle Metastasis From Thyroid Papillary Carcinoma

Tanaka

Kato

Aoki

et al. 2013

Neurol. Med. Chir.(Tokyo)

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A 63-year-old woman presented with a metastatic focus of papillary thyroid carcinoma in the cerebellopontine angle manifesting as lateral gazing nystagmus and slurred speech. Computed tomography demonstrated massive hemorrhage in the left cerebellar hemisphere. She was treated conservatively. Her symptoms resolved completely, but she experienced progressive deterioration in auditory acuity and ataxia over the next 6 months. Magnetic resonance imaging with gadolinium demonstrated an enhanced mass in the left cerebellopontine angle, and she was scheduled for elective resection of the tumor. Left retrosigmoid craniotomy was performed, and the tumor was subtotally removed except for a small amount at the junction of the trigeminal nerve and the pons. Histological examination confirmed a diagnosis of metastatic papillary thyroid carcinoma. The patient then underwent adjuvant gamma knife radiosurgery. Her clinical course was unremarkable, and her hypoacusis and ataxia resolved completely. Postoperative gallium scintigraphy revealed no residual tumor and no other systemic metastases. Hemorrhagic cerebellar metastasis from papillary thyroid carcinoma is extremely rare, but early recognition of metastatic cerebellar tumor should prompt immediate treatment to avoid the development of hearing loss, ataxia, and tonsillar herniation.

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Section: Introductionmentioning

confidence: 99%

Cerebellar Hemorrhage Secondary to Cerebellopontine Angle Metastasis From Thyroid Papillary Carcinoma

Tanaka

Kato

Aoki

et al. 2013

Neurol. Med. Chir.(Tokyo)

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“…Cerebellar metastases are even less common. Only 12 cases of metastatic changes in the cerebrum from DTC were reported in the literature, some of them occurring as solitary distant metastasis [2,3,[13][14][15][16][17]. The metastatic lesion in our patient was not solitary.…”

Section: Opis Przypadkumentioning

confidence: 60%

“…Brain metastases are very rare and cerebellar metastases are extremely rare [1][2][3]. Usually brain metastases are detected by means of radioiodine whole-body scan (WBS) or magnetic resonance.…”

Section: Introductionmentioning

confidence: 99%

Przerzut do móżdżku raka brodawkowatego tarczycy wykryty w scyntygrafii receptorów somatostatynowych

Czepczyński

Wyszomirska

Gryczyńska

et al. 2018

Endokrynologia Polska

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Introduction: Distant metastases of papillary thyroid carcinoma (PTC) may lack the ability to concentrate radioiodine. In such cases, positive somatostatin receptor scintigraphy might be useful in demonstrating the expression of somatostatin receptors that are potential therapeutic targets. To date, only a few cerebellar metastases from PTC have been reported in the literature. Patient findings:We present an 82-year-old female, in whom an asymptomatic cerebellar metastasis from PTC was diagnosed by means of Tc-99m-EDDA/HYNIC-TOC scintigraphy four years after the initial diagnosis. She was previously treated with total thyroidectomy and regional lymph node dissection, followed by three cycles of radioiodine therapy. Despite persistently elevated thyroglobulin, no specific radioiodine accumulation was found in the whole body post-treatment scan. Tc-99m-EDDA/HYNIC-TOC scintiscan revealed foci of increased tracer uptake in the lungs, cervical lymph nodes, and a single focus in the head. Thus, therapy with octreotide LAR was initiated. The patient died four months later due to disseminated PTC. Summary: In this paper, a patient with asymptomatic previously unknown non-iodine avid cerebellar metastasis of PTC diagnosed by means of scintigraphy using somatostatin analogue Tc-99m-EDDA/HYNIC-TOC is reported. Conclusions: Somatostatin receptor scintigraphy might be useful in the visualisation of non-iodine avid PTC metastases and demonstrating the expression of somatostatin receptors that are potential therapeutic targets. (Endokrynol Pol 2018; 69 (1): 24-27)

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“…The prognosis is usually excellent and the reported survival rates for non-metastatic lesions are 97.8% at 5 years and 94.9% at 10 years [6]. …”

Section: Discussionmentioning

confidence: 99%

Calvarial metastasis from papillary thyroid carcinoma: A case report

Bozkurt¹,

Ozdemir²,

Percinel³

et al. 2013

Pau Med J

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A large variety of metastatic tumors can be found in the skull; breast, prostate, lung carcinoma, multiple myeloma, neuroblastoma and sarcoma are among those that have been reported in the literature. In the current case, a very rare case of metastasis to skull from papillary thyroid carcinoma is reported. A 45-year-old man was admitted to our service with head trauma. Computed tomography and magnetic resonance imaging revealed lytic mass lesions in the right frontal and occipital bone extending through the dura mater and subcutaneous tissue. Right frontal, suboccipital craniectomy, tumor excision were performed and microscopic examination revealed papillary thyroid carcinoma metastasis. There is no consensus on treatment protocols for patients with central nervous system metastases from papillary thyroid carcinoma, most likely because of the rarity of cases. In the present case, we suggest that the best option for treatment of papillary thyroid carcinoma metastasis to skull would be surgery followed by radiotherapy. Pam Med J 2013;6(2):104-106Key words: Brain tumors, Craniotomy, Metastasis, Papillary Thyroid Carcinoma ÖzetKranial bölgeye bir çok farklı tümör metastaz yapabilmektedir; bunlar içerisinde meme, prostat, akciğer kanseri, multipl myeloma, nöroblastoma ve sarkoma sayılabilir. Bu yazıda çok nadir görülen papiller tiroid karsinomunun kraninuma metastazı sunulacaktır. 45 yaşında erkek hasta kafa travması şikayeti ile kliniğimize başvurdu. Çekilen kranial tomografi ve magnetik rezonans incelemelerinde sağ frontal ve oksipital kemikte dura mater ve subkutanöz dokulara uzanım gösteren litik kitle lezyonları tespit edildi. Çok nadir görülmesi nedeni ile papiller tiroid karsinomunun santral sinir sistemi metastazının tedavisi ile ilgili literatürde net bir tedavi şeması bulunmamaktadır. Bu yazı ile papiller tiroid karsinomunun kranial metastazında en uygun tedavi yönteminin cerrahi rezeksiyon ve ardından radyoterapi uygulaması şeklinde olduğu belirtilmiştir.

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Cerebellar Metastasis as First Metastasis from Papillary Thyroid Carcinoma

Cited by 35 publications

References 19 publications

Cerebellar Hemorrhage Secondary to Cerebellopontine Angle Metastasis From Thyroid Papillary Carcinoma

Cerebellar Hemorrhage Secondary to Cerebellopontine Angle Metastasis From Thyroid Papillary Carcinoma

Przerzut do móżdżku raka brodawkowatego tarczycy wykryty w scyntygrafii receptorów somatostatynowych

Calvarial metastasis from papillary thyroid carcinoma: A case report

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