2021
DOI: 10.1101/2021.02.17.431584
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Cerebellar modulation of fear behaviour and memory encoding in the PAG

Abstract: The pivotal role of the periaqueductal grey (PAG) in fear learning is reinforced by the identification of neurons in rat ventral (vPAG) that encode fear memory through signalling the onset and offset of an auditory conditioned stimulus during retrieval. Within this framework, understanding of cerebellar contributions to survival circuits is advanced by the discovery that: (i) reversible inactivation of the medial cerebellar nucleus (MCN) during fear consolidation (a) reduces the temporal precision of vPAG offs… Show more

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Cited by 2 publications
(5 citation statements)
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References 93 publications
(140 reference statements)
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“…Using a combination of virally guided chemo-and opto-genetics the authors were able to demonstrate that manipulation of this pathway can bidirectionally control the strength of fear memory formation in addition to extinction learning. These findings were further supported and extended by Lawrenson et al (2022) who also focussed on the fastigial nuclei interactions with vlPAG in rats and found that reversible inactivation of this nuclei using the GABA agonist muscimol during fear memory consolidation led to reduction in temporal encoding accuracy of vlPAG cells during subsequent recall. Furthermore, the authors also adopted a chemogenetic approach to inhibit fastigial projections to vlPAG specifically during fear acquisition and observed a slower rate of fear extinction learning.…”
Section: Physiological and Functional Substrates Of Distributed Cereb...supporting
confidence: 58%
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“…Using a combination of virally guided chemo-and opto-genetics the authors were able to demonstrate that manipulation of this pathway can bidirectionally control the strength of fear memory formation in addition to extinction learning. These findings were further supported and extended by Lawrenson et al (2022) who also focussed on the fastigial nuclei interactions with vlPAG in rats and found that reversible inactivation of this nuclei using the GABA agonist muscimol during fear memory consolidation led to reduction in temporal encoding accuracy of vlPAG cells during subsequent recall. Furthermore, the authors also adopted a chemogenetic approach to inhibit fastigial projections to vlPAG specifically during fear acquisition and observed a slower rate of fear extinction learning.…”
Section: Physiological and Functional Substrates Of Distributed Cereb...supporting
confidence: 58%
“…Based upon classical Pavlovian conditioning paradigms in which a neutral stimulus is paired with an aversive stimulus, such as an electrical shock (Pavlov, 2010), ground-breaking studies in humans (Ernst et al, 2019;Batsikadze et al, 2022) and rodents (Frontera et al, 2020;Vaaga et al, 2020;Lawrenson et al, 2022) have begun to detail the neural dynamics within these circuits during fear. Importantly, Pavlovian conditioning allows assessment of fear memory formation, which occurs during or following the initial conditioning stage and fear extinction learning, when the conditioned stimulus is repeatedly presented alone.…”
Section: Physiological and Functional Substrates Of Distributed Cereb...mentioning
confidence: 99%
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