Cerebellar oscillatory dysfunction during lower-limb movement in Parkinson’s disease with freezing of gait

Bosch, Taylor J.; Espinoza, Arturo I.; Singh, Anneliese A.

doi:10.1016/j.brainres.2023.148334

Cited by 6 publications

(4 citation statements)

References 47 publications

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“…PD-PIGD patients also demonstrate increased activity in non-motor cerebellar areas during gait-simulating tasks, most likely as a compensatory response to the functional failure of the motor areas of the cerebellum and basal ganglia [112]. PD patients who experience gait freezing during lower-limb movements demonstrate reduced theta oscillations and attenuated cue-triggered theta-band power via the mid-cerebellar Cbz electrode in electroencephalography (EEG) studies during motor tasks [119,120].…”

Section: Parkinson's Disease (Pd)mentioning

confidence: 99%

Aging, Neurodegenerative Disorders, and Cerebellum

Iskusnykh,

Zakharova,

Kryl’skii

et al. 2024

IJMS

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An important part of the central nervous system (CNS), the cerebellum is involved in motor control, learning, reflex adaptation, and cognition. Diminished cerebellar function results in the motor and cognitive impairment observed in patients with neurodegenerative disorders such as Alzheimer’s disease (AD), vascular dementia (VD), Parkinson’s disease (PD), Huntington’s disease (HD), spinal muscular atrophy (SMA), amyotrophic lateral sclerosis (ALS), Friedreich’s ataxia (FRDA), and multiple sclerosis (MS), and even during the normal aging process. In most neurodegenerative disorders, impairment mainly occurs as a result of morphological changes over time, although during the early stages of some disorders such as AD, the cerebellum also serves a compensatory function. Biological aging is accompanied by changes in cerebellar circuits, which are predominantly involved in motor control. Despite decades of research, the functional contributions of the cerebellum and the underlying molecular mechanisms in aging and neurodegenerative disorders remain largely unknown. Therefore, this review will highlight the molecular and cellular events in the cerebellum that are disrupted during the process of aging and the development of neurodegenerative disorders. We believe that deeper insights into the pathophysiological mechanisms of the cerebellum during aging and the development of neurodegenerative disorders will be essential for the design of new effective strategies for neuroprotection and the alleviation of some neurodegenerative disorders.

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Section: Parkinson's Disease (Pd)mentioning

confidence: 99%

Aging, Neurodegenerative Disorders, and Cerebellum

Iskusnykh,

Zakharova,

Kryl’skii

et al. 2024

IJMS

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“…Cerebellar evoked responses have also been recorded following impulsive acceleration applied on the mastoid and the trunk [59,60], opening new possibilities to explore cerebellar involvement in postural control. This avenue has resulted in a small number of clinical applications so far, with two studies suggesting that a decrease in cerebellar theta activity is linked to postural instability and the freezing of gait in Parkinson's disease [61,62].…”

Section: Novel Biomarkers For Electrical Cerebellar Activity In Humansmentioning

confidence: 99%

Cerebellar Non-Invasive Brain Stimulation: A Frontier in Chronic Pain Therapy

Sveva,

Cruciani,

Mancuso

et al. 2024

JPM

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Chronic pain poses a widespread and distressing challenge; it can be resistant to conventional therapies, often having significant side effects. Non-invasive brain stimulation (NIBS) techniques offer promising avenues for the safe and swift modulation of brain excitability. NIBS approaches for chronic pain management targeting the primary motor area have yielded variable outcomes. Recently, the cerebellum has emerged as a pivotal hub in human pain processing; however, the clinical application of cerebellar NIBS in chronic pain treatment remains limited. This review delineates the cerebellum’s role in pain modulation, recent advancements in NIBS for cerebellar activity modulation, and novel biomarkers for assessing cerebellar function in humans. Despite notable progress in NIBS techniques and cerebellar activity assessment, studies targeting cerebellar NIBS for chronic pain treatment are limited in number. Nevertheless, positive outcomes in pain alleviation have been reported with cerebellar anodal transcranial direct current stimulation. Our review underscores the potential for further integration between cerebellar NIBS and non-invasive assessments of cerebellar function to advance chronic pain treatment strategies.

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“…This event-triggered crosstalk leads to gait initiation lock or FoG [ 14 ]. It is also plausible that impaired connectivity between the cortico-BG circuits and the cerebellum contribute to the appearance of FoG in PD [ 15 ] potentially reflecting neuronal activity deficits also in the cerebellum [ 16 ], which was implicated with complex gait conditions [ 17 ]. BG: basal ganglia, CPGs: central pattern generators, MLR: mesencephalic locomotor network, PMRF: pontomedullary reticular formation, SMA: supplementary motor area, SN: substantia nigra, STN: subthalamic nucleus, TH: thalamus, and VTA: ventral tegmental area.…”

Section: Figurementioning

confidence: 99%

Supplementary Motor Area Activity Differs in Parkinson’s Disease with and without Freezing of Gait

Marquez,

Bartsch,

Günther

et al. 2023

Parkinson's Disease

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The study aimed to investigate the neural changes that differentiate Parkinson’s disease patients with freezing of gait and age-matched controls, using ambulatory electroencephalography event-related features. Compared to controls, definite freezers exhibited significantly less alpha desynchronization at the motor cortex about 300 ms before and after the start of overground walking and decreased low-beta desynchronization about 300 ms before and about 300 and 700 ms after walking onset. The late slope of motor potentials also differed in the sensory and motor areas between groups of controls, definite, and probable freezers. This difference was found both in preparation and during the execution of normal walking. The average frontal peak of motor potential was also found to be largely reduced in the definite freezers compared with the probable freezers and controls. These findings provide valuable insights into the underlying structures that are affected in patients with freezing of gait, which could be used to tailor drug development and personalize drug care for disease subtypes. In addition, the study’s findings can help in the evaluation and validation of nonpharmacological therapies for patients with Parkinson’s disease.

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Cerebellar oscillatory dysfunction during lower-limb movement in Parkinson’s disease with freezing of gait

Cited by 6 publications

References 47 publications

Aging, Neurodegenerative Disorders, and Cerebellum

Aging, Neurodegenerative Disorders, and Cerebellum

Cerebellar Non-Invasive Brain Stimulation: A Frontier in Chronic Pain Therapy

Supplementary Motor Area Activity Differs in Parkinson’s Disease with and without Freezing of Gait

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