Cerebellar peduncle myelinolysis: case report

Mangat, K.; Sherlala, Khaled

doi:10.1007/s00234-002-0845-4

Cited by 6 publications

(3 citation statements)

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“…However, the middle cerebellar peduncles can be a ected with or without a pontine lesion. 4 Our patient had both central pontine and bilateral middle cerebellar peduncular lesions (Fig. 3).…”

Section: Extrapontine Myelinolysismentioning

confidence: 72%

Symmetrical Lesions of the Middle Cerebellar Peduncle: MR Imaging and Differential Diagnosis

Uchino

Sawada

Takase

et al. 2004

MRMS

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The purpose of this paper is to show several diseases that manifest symmetrical hyperintense lesions on the middle cerebellar peduncles, the largest connecting peduncles between the brainstem and the cerebellum, in conventional magnetic resonance (MR) images. We retrospectively reviewed cranial MR images obtained with 0.3 , 0.5 , 1.0 , and 1.5 Tesla scanners. We found symmetrical middle cerebellar peduncular lesions in patients with Wilson's disease; hepatic encephalopathy; extrapontine myelinolysis; acute dissemi nated encephalomyelitis; wallerian degeneration of the pontocerebellar tracts after either pontine infarction, pontine hemorrhage, or central pontine myelinolysis; leukodystrophy; olivopontocerebellar atrophy; and toluene abuse. De nitive diagnosis of these diseases can be made relatively easily on the basis of clinical data; however, examination of associated brainstem or supratentorial lesions in MR images is also important.

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Section: Extrapontine Myelinolysismentioning

confidence: 72%

Symmetrical Lesions of the Middle Cerebellar Peduncle: MR Imaging and Differential Diagnosis

Uchino

Sawada

Takase

et al. 2004

MRMS

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“…Follow‐up MRI on POD 20 showed progressive disease consistent with EPM. Although the involvement of EPM in the cerebellar peduncles is uncommon, such lesions have been reported (21, 22). Despite the radiographic progression of myelinolysis, the ADC calculations showed gradual resolution of demyelination in the pons, corresponding to the patient’s slow clinical recovery marked by increased responsiveness and spontaneous eye opening.…”

Section: Discussionmentioning

confidence: 99%

Central pontine myelinolysis: A case report and clinical–pathological review

Cui

Fayek

Rand

et al. 2011

Pediatric Transplantation

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An 11-yr-old child presented with acute mental status changes and spastic quadriplegia after orthotopic liver transplantation. Magnetic resonance (MR) imaging findings were consistent with central pontine and EPM. Initial immunosuppression included tacrolimus, mycophenolate mofetil, and corticosteroids. Given that neurotoxicity is a well-established side effect of CNI, the patient was converted to rapamycin and subsequently experienced significant neurologic recovery. The temporal resolution of the patient's symptoms suggests that prompt recognition of central pontine and EPM and conversion from tacrolimus to rapamycin during the early post-operative course may have therapeutic benefits for patients undergoing pediatric transplant with CNI-related neurotoxicity.

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“…As far as the authors of this study are aware, extrapontine myelinolysis of the cerebellar peduncle has been reported in only one case [5], in which the patient was an alcoholic. We encountered a case of extrapontine myelinolysis in a patient who had received regular hemodialysis as treatment for endstage renal disease.…”

Section: Introductionmentioning

confidence: 89%