Cerebellar rTMS stimulation may induce prolonged clinical benefits in essential tremor, and subjacent changes in functional connectivity: An open label trial

Popa, Traian; Russo, Margherita; Vidailhet, Marie; Roze, Emmanuel; Lehericy, Stéphane; Bonnet, Catherine; Apartis, Emmanuelle; Legrand, A. P.; Marais, Lea; Meunier, Sabine; Gallea, Cécile

doi:10.1016/j.brs.2012.04.009

Cited by 130 publications

(127 citation statements)

References 23 publications

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“…4A, graph). In other diseases, evidence that a specific site of noninvasive stimulation is ineffective is not as strong; however, in general, stimulation of cerebellum appears to be more effective for essential tremor than stimulation of M1 (53)(54)(55)(56)(57), stimulation of M1 appears to be more effective for pain than stimulation of DLPFC (58)(59)(60)(61), and stimulation of the left DLPFC appears to be more effective for depression than stimulation of the cranial vertex (top of the head) (17). In all cases, the DBS site with the best evidence of efficacy was significantly more connected to the sites where noninvasive stimulation was effective than to sites where noninvasive stimulation was ineffective, with connectivity to the ineffective site falling at or below the connectivity to random sites (Fig.…”

Section: Resultsmentioning

confidence: 99%

Resting-state networks link invasive and noninvasive brain stimulation across diverse psychiatric and neurological diseases

Fox

Buckner

Liu

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

526

435

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Significance Brain stimulation is a powerful treatment for an increasing number of psychiatric and neurological diseases, but it is unclear why certain stimulation sites work or where in the brain is the best place to stimulate to treat a given patient or disease. We found that although different types of brain stimulation are applied in different locations, targets used to treat the same disease most often are nodes in the same brain network. These results suggest that brain networks might be used to understand why brain stimulation works and to improve therapy by identifying the best places to stimulate the brain.

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Section: Resultsmentioning

confidence: 99%

Resting-state networks link invasive and noninvasive brain stimulation across diverse psychiatric and neurological diseases

Fox

Buckner

Liu

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

526

435

View full text Add to dashboard Cite

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“…Recent research has also investigated the effect of repeated sessions of NIBS on functional connectivity and behavior. Popa et al (2013) applied 5 daily sessions of cerebellar rTMS to a cohort of patients with essential tremor. Following the repeated sessions of rTMS, patients showed an improvement in their tremor and restoration of functional connectivity in the affected cerebello-thalamo-cortical network to levels M a n u s c r i p t Sale et al,35 nearing those reported in normal controls.…”

Section: Other Considerationsmentioning

confidence: 99%

Imaging human brain networks to improve the clinical efficacy of non-invasive brain stimulation

Sale¹,

Mattingley²,

Zalesky³

et al. 2015

Neuroscience & Biobehavioral Reviews

127

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“…The lower inter‐rater reliability and the subjective nature of the clinical rating scales (Elble et al., 2013) can be mitigated by objective accelerometry measures (i.e., the tremor frequency and amplitude), which may provide a more accurate representation of the disease pathophysiological features. This is suggested by recent functional and morphometric MRI studies (Gallea et al., 2015; Popa et al., 2013). Using MRI morphometry, Gallea and colleagues showed that the cerebellar vermis volume was uniquely correlated to tremor frequency but not to FTM clinical scale (Gallea et al., 2015).…”

Section: Introductionmentioning

confidence: 99%

“…Using MRI morphometry, Gallea and colleagues showed that the cerebellar vermis volume was uniquely correlated to tremor frequency but not to FTM clinical scale (Gallea et al., 2015). Functional MRI data also demonstrated a relationship between connectivity within CTC and accelerometry tremor measures (Gallea et al., 2015; Popa et al., 2013). Although these recent MRI studies (Gallea et al., 2015; Popa et al., 2013) do imply a link between objective tremor measures and structural brain changes within CTC, there have been no studies that specifically investigated the correlation between the WM changes in ET and tremor amplitude and frequency.…”

Section: Introductionmentioning

confidence: 99%

White matter measures correlate with essential tremor severity—A pilot diffusion tensor imaging study

et al. 2018

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BackgroundAn evolving pathophysiological concept of essential tremor (ET) points to diffuse brain network involvement, which emphasizes the need to investigate white matter (WM) changes associated with motor symptoms of ET.ObjectivesTo investigate ET‐related WM changes and WM correlates of tremor severity using tremor clinical rating scales and accelerometry.MethodsTract‐based spatial statistics (TBSS) approach was utilized to compare 3 Tesla diffusion tensor imaging (DTI) data from 12 ET patients and 10 age‐ and gender‐matched healthy individuals. Clinical scales, tremor frequency and amplitude as measured by accelerometry were correlated with DTI data.Results ET patients demonstrated mean (MD) and radial diffusivity (RD) abnormalities in tracts involved in primary and associative motor functions such as bilateral corticospinal tracts, the superior longitudinal fascicles, and the corpus callosum but also in nonmotor regions including the inferior fronto‐occipital and longitudinal fascicles, cingulum bundles, anterior thalamic radiations, and uncinate fascicles. A combined tremor frequency and amplitude score correlated with RD and MD in extensive WM areas, which partially overlapped the regions that were associated with tremor frequency. No significant relationship was found between DTI measures and clinical rating scales scores.ConclusionsThe results show that ET‐related diffusion WM changes and their correlates with tremor severity are preferentially located in the primary and associative motor areas. In contrast, a relationship between WM was not detected with clinical rating scales. Accelerometry parameters may, therefore, serve as a potentially useful clinical measures that relate to WM deficits in ET.

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Cerebellar rTMS stimulation may induce prolonged clinical benefits in essential tremor, and subjacent changes in functional connectivity: An open label trial

Cited by 130 publications

References 23 publications

Resting-state networks link invasive and noninvasive brain stimulation across diverse psychiatric and neurological diseases

Resting-state networks link invasive and noninvasive brain stimulation across diverse psychiatric and neurological diseases

Imaging human brain networks to improve the clinical efficacy of non-invasive brain stimulation

White matter measures correlate with essential tremor severity—A pilot diffusion tensor imaging study

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