Cerebellous metastases in patients with uterine cervical cancer. Two cases reports and review of the literature

Omari-Alaoui, H El; Gaye, Papa Macoumba; Kebdani, Tayeb; Ghazi, E. El; Benjaafar, Noureddine; Mansouri, Abdellah; Errihani, Hassan; Kettani, Fouad; Ouahabi, Abdeldjalil; Gueddari, B.K. El

doi:10.1016/s1278-3218(03)00085-4

Cited by 12 publications

(28 citation statements)

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“…Neurologic symptoms were present in almost all patients, of which headache was the most common in our series and in most reported cases (4,5,8,(10)(11)(12)(13)(14)(15)(16) . Ikeda et al identified nausea and vomiting as the most prevalent symptoms, but even in this series, headache was common (7) .…”

Section: Discussionsupporting

confidence: 51%

“…Treatment characteristics of whole-brain irradiation are shown in Table 3. The median dose was 3750 cGy (range 3000-4000 cGy), given over a median of 11 fractions (range [10][11][12][13][14][15][16][17][18][19][20]. Two of the four patients with solitary lesions received a stereotactic boost to the tumor site.…”

Section: Resultsmentioning

confidence: 99%

“…Metastatic disease, which heralds mortality in most cases, typically occurs via local extension and lymphatic dissemination. When distant, hematogenous metastases do occur; typical sites include the liver, the lung, and the bone (3) .Brain metastasis from cervical cancer is rare, with less than 100 cases identified in a search of the English medical literature (Pubmed, no date restriction, search terms include cervical cancer, brain metastasis, CNS metastasis, cervical carcinoma) (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19) . Of these, only three manuscripts reported more than three patients (5,7,10) .…”

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confidence: 99%

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Brain metastasis from cervical carcinoma

Chura

Shukla

Argenta

2007

Int J Gynecol Cancer

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The aim of this study was to describe the features of patients with brain metastasis from cervical cancer. Twelve patients with brain metastasis from cervical cancer were identified. Information regarding symptoms, treatment, and survival was analyzed. The incidence of brain metastasis in our population was 0.77%. Median patient age at initial diagnosis of cervical cancer was 43.5 years (range 29-57 years) compared with 44.5 years (range 31-58 years) at identification of brain metastasis. Six patients had FIGO stage IB disease; three had stage IIB disease; and one each had stage IIIA, IIIB, and IVB disease. The median interval from diagnosis of cervical cancer to identification of brain metastasis was 17.5 months (range 1.1-96.1 months). All but one patient presented with neurologic symptoms. Eight patients received whole-brain irradiation and steroids, three received steroids alone, and one underwent surgery, followed by irradiation. All the patients who received whole-brain irradiation experienced improvement in their symptoms. Median survival from diagnosis of brain metastasis to death was 2.3 months (range 0.3-7.9 months). Five patients who received chemotherapy after brain irradiation had a median survival of 4.4 months compared to 0.9 months for those who received no additional treatment after brain irradiation (P= .016). Most patients with brain metastasis from cervical cancer presented with neurologic sequelae. Brain irradiation improved these symptoms. Survival after diagnosis of brain metastasis was poor; however, patients who received chemotherapy after brain irradiation appeared to have improved survival.

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Section: Discussionsupporting

confidence: 51%

Section: Resultsmentioning

confidence: 99%

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confidence: 99%

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Brain metastasis from cervical carcinoma

Chura

Shukla

Argenta

2007

Int J Gynecol Cancer

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“…2 Uterine cervical cancer is a rare lesion as the primary site of pancreatic metastasis, and when it metastasizes, the retroperitoneal lymph nodes, lung, bone, and liver are usually targeted. 4,5 Metastasis to the pancreas from uterine cervical carcinoma is very rare and 3 cases in clinical series [6][7][8] and 13 cases in autopsy series 9,10 having been reported. Recently, endoscopic ultrasonography-guided fine needle aspiration (EUS-FNA) is noted for its accuracy and safety in cytology and biopsy of the pancreas.…”

Section: Dear Dr Bedrossianmentioning

confidence: 99%

Pancreatic metastasis from small cell carcinoma of the uterine cervix demonstrated by endoscopic ultrasonography‐guided fine needle aspiration

Kuwatani

Asaka

Marukawa

et al. 2008

Diagnostic Cytopathology

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“…Despite the fact that metastatic brain tumors are said to constitute up to 50% of adult brain tumors, those arising from cervical cancer are a rare event, with an incidence rate between 0.4 to 1.2% among cervical cancer cases (3,4,7,13). Therefore, there are only case reports or small case series related to these rare metastases in the english medical literature (10)(11)(12)(15)(16)(17). The median survival time from determination of brain metastasis from █ INTRODUCTION U terine cervical cancer is the second most common malignancy in women worldwide (9,14,16).…”

Section: Introductionmentioning

confidence: 99%

The impact of the stage and tumor size on rare brain metastasis of cervical cancer

Teke

Tunç²,

Teke³

et al. 2015

Turkish Neurosurgery

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ABSTRACTand extrapelvic lymph nodes (1,8). Despite the fact that metastatic brain tumors are said to constitute up to 50% of adult brain tumors, those arising from cervical cancer are a rare event, with an incidence rate between 0.4 to 1.2% among cervical cancer cases (3,4,7,13). Therefore, there are only case reports or small case series related to these rare metastases in the english medical literature (10)(11)(12)(15)(16)(17). The median survival time from determination of brain metastasis from █ INTRODUCTION U terine cervical cancer is the second most common malignancy in women worldwide (9,14,16). It spreads most often via local extension and through the lymphatics to the retroperitoneal lymph nodes. Distant organs are reached by hematogenous dissemination, which occurs infrequently, but especially influences the lungs, liver, bones, AIm: To investigate the clinical features, prognostic factors and survival times of cervical cancer patients with brain metastasis. mATERIAl and mEThODS:We retrospectively reviewed the medical records of 820 patients with cervical cancer. Data were analyzed using SPSS version 12.0 statistical software (SPSS, Chicago, IL, uSA). Overall survival, time interval from diagnosis of cervical cancer to identification of brain metastasis, and median survival time after diagnosis of brain metastasis were calculated using Kaplan-Meier curve analysis. The log-rank test was used to compare differences in survival. Differences were assumed statistically significant when p-values were <0.05. RESUlTS:The incidence of brain metastases from cervical cancer in our institution was 1.82% (15/820) over a ten-year period. The median time interval from diagnosis of cervical cancer to detection of brain metastasis was 12.5 months (range: 2.9-91.9 months). Stage and tumor diameter were found to be significant relating to the interval from diagnosis of cervical cancer to detection of brain metastasis (p=0.001 for both). CONClUSION:This study provides much information about the prognosis of patients with brain metastases from cervical cancer and highlights the importance of initial stage and tumor diameter when determining the time interval until development of brain metastasis.

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Cerebellous metastases in patients with uterine cervical cancer. Two cases reports and review of the literature

Cited by 12 publications

References 9 publications

Brain metastasis from cervical carcinoma

Brain metastasis from cervical carcinoma

Pancreatic metastasis from small cell carcinoma of the uterine cervix demonstrated by endoscopic ultrasonography‐guided fine needle aspiration

The impact of the stage and tumor size on rare brain metastasis of cervical cancer

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