Cerebellum and auditory function: An ALE meta‐analysis of functional neuroimaging studies

Petacchi, Augusto; Laird, Angela R.; Fox, Peter T.; Bower, James M.

doi:10.1002/hbm.20137

Cited by 208 publications

(195 citation statements)

References 111 publications

(128 reference statements)

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“…Finally, extensive activation was seen in right lateralized crus I and II in posterior cerebellum. Recent evidence suggests that the latter regions support aspects of verbal working memory or phonological encoding (25). (Similar results are obtained when valid and invalid trials are analyzed separately; see SI Appendix, Fig.…”

Section: Resultssupporting

confidence: 70%

The boundaries of language and thought in deductive inference

Monti

Parsons

Osherson

2009

Proc. Natl. Acad. Sci. U.S.A.

151

182

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Is human thought fully embedded in language, or do some forms of thought operate independently? To directly address this issue, we focus on inference-making, a central feature of human cognition. In a 3T fMRI study we compare logical inferences relying on sentential connectives (e.g., not, or, if . . . then) to linguistic inferences based on syntactic transformation of sentences involving ditransitive verbs (e.g., give, say, take). When contrasted with matched grammaticality judgments, logic inference alone recruited ''core'' regions of deduction [Brodmann area (BA) 10p and 8m], whereas linguistic inference alone recruited perisylvian regions of linguistic competence, among others (BA 21, 22, 37, 39, 44, and 45 and caudate). In addition, the two inferences commonly recruited a set of general ''support'' areas in frontoparietal cortex (BA 6, 7, 8, 40, and 47). The results indicate that logical inference is not embedded in natural language and confirm the relative modularity of linguistic processes.fMRI ͉ logic ͉ reasoning ͉ semantics ͉ syntax T he interplay between language and thought is pivotal to the study of human cognition (1-4). A principal issue is the extent to which thinking is embedded in language (5, 6). Within neuroscience, the matter has been explored in the domain of arithmetic (7), music (8), theory of mind (9), and deductive reasoning (10, 11). In the case of deduction, however, the evidence is highly contradictory. Some studies report that logic inference recruits neural structures traditionally engaged by linguistic processing (10, 12). These findings would suggest that thought is deeply rooted in language, a view consistent with certain psychological and philosophical perspectives on deduction (13,14). Other studies have failed to detect such activity (15, 16), which counts against the hypothesis that reasoning is tributary to language. These competing interpretations, however, are entirely based on indirect secondary observation qualitatively comparing language activations in one study to logic activations in another study across different methods, materials, paradigms, and subjects. In the present study we address this issue directly by comparing, within the same group of participants, inference based on logic connectives to inferences based on the syntax and semantics of ditransitive verbs.Consider, for example, arguments 1a and 2a in Table 1 (each with a single premise). The two arguments are equally valid in the sense that the truth of their respective premises guarantees the truth of their conclusions. But their validity rests on vocabulary from different lexical categories. The validity of argument 1a is based on the sentential connectives ''if . . . then,'' ''or,'' etc., whereas the validity of argument 2a depends on the principal phrasal verb (and similarly for the invalidity of arguments 1b and 2b, respectively). The semantic contrast between the two cases is apparent although difficult to characterize precisely (17). Roughly, connectives do not contribute to the topic of a sentence a...

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Section: Resultssupporting

confidence: 70%

The boundaries of language and thought in deductive inference

Monti

Parsons

Osherson

2009

Proc. Natl. Acad. Sci. U.S.A.

151

182

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“…The coordinates of the reported cerebellum activation (i.e., -19 -41 -20 for weaker musical relations (Tillmann et al, 2003), and -32 -57 -23 for the same musical relations 1 ) were close to those reported in an activation likelihood estimate meta-analysis for a wide range of auditory tasks (-44 -50 -32 (crus I) and -20 -50 -22 (lobule V) (Petacchi et al, 2005)). Beyond being part of a network supporting increased auditory processing, the increased cerebellar activation might be linked to a cerebellar role in generating musical expectations based on knowledge of prototypical sequences and association strengths in music.…”

Section: Nih Public Accesssupporting

confidence: 73%

“…A seminal fMRI paper by Gao et al (1996) reported that the dentate nuclei of the cerebellum were more active during manual tasks that emphasized sensory discrimination, rather than during movement per se. Neuroimaging studies have shown increased activation of the cerebellum during auditory tasks (Petacchi et al, 2005), such as frequency, intensity and duration discrimination (Belin et al, 2002), the processing of complex nonspeech sounds over pure tones (Vouloumanos et al, 2001), as well as for auditory attention (Janata, Tillmann, & Bharucha, 2002) and the perception of musical structures (Parsons, 2001;Tillmann, Janata, & Bharucha, 2003). Work in auditory perception is just one piece of a larger emerging picture that suggests potential cerebellar contributions to higher cognitive functions involving memory and language (see Fiez, 1996;Justus & Ivry, 2001 for reviews).…”

mentioning

confidence: 99%

Cerebellar patients demonstrate preserved implicit knowledge of association strengths in musical sequences

Tillmann

Justus

Bigand

2008

Brain and Cognition

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Recent findings suggest the involvement of the cerebellum in perceptual and cognitive tasks. Our study investigated whether cerebellar patients show musical priming based on implicit knowledge of tonal-harmonic music. Participants performed speeded phoneme identification on sung target chords, which were either related or less-related to prime contexts in terms of the tonal-harmonic system. As groups, both cerebellar patients and age-matched controls showed facilitated processing for related targets, as previously observed for healthy young adults. The outcome suggests that an intact cerebellum is not mandatory for accessing implicit knowledge stored in long-term memory and for its influence on perception. One patient showed facilitated processing for less-related targets (suggesting sensory priming). The findings suggest directions for future research on auditory perception in cerebellar patients to further our understanding of cerebellar functions. Keywordsnonverbal auditory perception/music perception; implicit knowledge; music cognition; cerebellum; cognitive priming; neuropsychology Numerous neuropsychological and neuroimaging findings suggest that the function of the cerebellum is not restricted to movement and motor control, but extends to perceptual and cognitive capacities. A seminal fMRI paper by Gao et al. (1996) reported that the dentate nuclei of the cerebellum were more active during manual tasks that emphasized sensory discrimination, rather than during movement per se. Neuroimaging studies have shown increased activation of the cerebellum during auditory tasks (Petacchi et al., 2005), such as frequency, intensity and duration discrimination (Belin et al., 2002), the processing of complex nonspeech sounds over pure tones (Vouloumanos et al., 2001), as well as for auditory attention (Janata, Tillmann, & Bharucha, 2002) and the perception of musical structures (Parsons, 2001;Tillmann, Janata, & Bharucha, 2003). Work in auditory perception is just one piece of a larger emerging picture that suggests potential cerebellar contributions to higher cognitive functions involving memory and language (see Fiez, 1996;Justus & Ivry, 2001 for reviews). Although the cerebellum seems to be implicated in perceptual and cognitive functions, no Correspondence concerning this article should be addressed to: Barbara Tillmann, Université Claude Bernard -Lyon I, CNRS UMR 5020, Neurosciences et Systèmes Sensoriels, 50 Av. Tony Garnier, F-69366 Lyon Cedex 07, France, Tel : +33 (0) 4 37 28 74 93, Fax : +33 (0) 4 37 28 76 01, barbara.tillmann@olfac.univ-lyon1.fr. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers...

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“…Though one possibility is that the pathophysiological mechanism underlying these lesions was crossed cerebellocerebral diaschisis (e.g., Cook et al, 2004), it is equally possible that they reflect ipsilateral cerebellar cerebral diaschisis, implying that the cerebellum might be bilaterally involved in language processing (Murdoch & Whelan, 2007). Another exception to the lateralization of linguistic function is to be found in prosodic and auditory language processing, that both seem to be left lateralized within the cerebellum (e.g., Callan et al, 2007;Petacchi et al, 2005).…”

Section: Functional Topography Of the Cerebellummentioning

confidence: 99%

Internal modeling of upcoming speech: A causal role of the right posterior cerebellum in non-motor aspects of language production

Runnqvist

Bonnard

Gauvin

et al. 2016

Cortex

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Some language processing theories propose that, just as for other somatic actions, self-monitoring of language production is achieved through internal modeling. The cerebellum is the proposed center of such internal modeling in motor control, and the right cerebellum has been linked to an increasing number of language functions, including predictive processing during comprehension.Relating these findings, we tested whether the right posterior cerebellum has a causal role for self-monitoring of speech errors. Participants received 1Hz repetitive transcranial magnetic stimulation during 15 minutes to lobules Crus I and II in the right hemisphere, and, in counterbalanced orders, to the contralateral area in the left cerebellar hemisphere (control) in order to induce a temporary inactivation of one of these zones. Immediately afterwards, they engaged in a speech production task priming the production of speech errors.Language production was impaired after right compared to left hemisphere stimulation, a finding that provides evidence for a causal role of the cerebellum during language production. We interpreted this role in terms of internal modeling of upcoming speech through a verbal working memory process used to prevent errors.

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Cerebellum and auditory function: An ALE meta‐analysis of functional neuroimaging studies

Cited by 208 publications

References 111 publications

The boundaries of language and thought in deductive inference

The boundaries of language and thought in deductive inference

Cerebellar patients demonstrate preserved implicit knowledge of association strengths in musical sequences

Internal modeling of upcoming speech: A causal role of the right posterior cerebellum in non-motor aspects of language production

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