Cerebellum and Emotion in Social Behavior

Clausi, Silvia; Siciliano, Libera; Olivito, Giusy; Leggio, Maria

doi:10.1007/978-3-030-99550-8_15

Cited by 7 publications

(5 citation statements)

References 144 publications

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“…However, it has to be underlined that in the study by Martino et al ( 2011 ), between group difference were only tested for total RMET score while in the present study, we also investigated between-group difference according to the mental states’ valence (positive, negative or neutral; Hudson et al, 2020 ), and showed a selective alteration when BD patients process stimuli with negative valence. This is also consistent with the evidence that cerebellar recruitment is particularly critical for negative emotions (Ferrucci et al, 2012 ; Clausi et al, 2022 ). In conclusion, the social cognition profiles and the pattern of cerebellar correlations differentiating the two groups support at least in part the hypothesis that different social neural networks underlie different ToM components (Lee et al, 2004 ; Sabbagh, 2004 ).…”

Section: Discussionsupporting

confidence: 91%

Theory of mind profile and cerebellar alterations in remitted bipolar disorder 1 and 2: a comparison study

Olivito

Lupo²,

Siciliano

et al. 2022

Front. Behav. Neurosci.

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The literature on social cognition abilities in bipolar disorder (BD) is controversial about the occurrence of theory of mind (ToM) alterations. In addition to other cerebral structures, such as the frontal and limbic areas, the processing of socially relevant stimuli has also been attributed to the cerebellum, which has been demonstrated to be involved in the above-mentioned disorder. Nevertheless, the cerebellar contribution to ToM deficits in bipolar patients needs to be elucidated further. To this aim, two tests assessing different components of ToM were used to evaluate the ability to appreciate affective and mental states of others in 17 individuals with a diagnosis of BD type 1 (BD1) and 13 with BD type 2 (BD2), both in the euthymic phase, compared to healthy matched controls. Cerebellar gray matter (GM) volumes were extracted and compared between BD1 and controls and BD2 and controls by using voxel-based morphometry. The results showed that BD1 patients were compromised in the cognitive and advanced components of ToM, while the BD2 ToM profile resulted in a more widespread compromise, also involving affective and automatic components. Both overlapping and differing areas of cerebellar GM reduction were found. The two groups of patients presented a pattern of GM reduction in cerebellar portions that are known to be involved in the affective and social domains, such as the vermis and Crus I and Crus II. Interestingly, in both BD1 and BD2, positive correlations were detected between lower ToM scores and decreased volumes in the cerebellum. Overall, BD2 patients showed a more compromised ToM profile and greater cerebellar impairment than BD1 patients. The different patterns of structural abnormalities may account for the different ToM performances evidenced, thus leading to divergent profiles between BD1 and BD2.

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Section: Discussionsupporting

confidence: 91%

Theory of mind profile and cerebellar alterations in remitted bipolar disorder 1 and 2: a comparison study

Olivito

Lupo²,

Siciliano

et al. 2022

Front. Behav. Neurosci.

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“…, 2017 ). Together with recent research on the socio-cognitive role of the cerebellum (see Baumann and Mattingley, 2022 ; Clausi et al. , 2022 ), our data implies that the cerebellum should be included in future analyses of ER.…”

Section: Discussionsupporting

confidence: 71%

Structural brain changes in emotion recognition across the adult lifespan

Karl,

Rohe

2023

Social Cognitive and Affective Neuroscience

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Emotion recognition (ER) declines with increasing age, yet little is known whether this observation bases on structural brain changes conveyed by differential atrophy. To investigate whether age-related ER decline correlates with reduced grey matter (GM) volume in emotion-related brain regions, we conducted a voxel-based morphometry analysis using data of the Human Connectome Project-Aging (N = 238, aged 36 - 87) in which facial ER was tested. We expected to find brain regions that show an additive or super-additive age-related change in GM volume indicating atrophic processes that reduce ER in older adults. The data did not support our hypotheses after correction for multiple comparisons. Exploratory analyses with a threshold of p < .001 (uncorrected), however, suggested that relationships between GM volume and age-related general ER may be widely distributed across the cortex. Yet, small effect sizes imply that only a small fraction of the decline of ER in older adults can be attributed to local GM volume changes in single voxels or their multivariate patterns.

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“…Based on the fMRI findings, significant clusters in the bilateral cerebellum were observed during the unaffected hand movements after rTMS, suggesting the cerebellum play a role in stroke recovery ( 35 ). The cerebellum maintains many neural connections with the motor cortex, which controls motor skills such as motor coordination, fine motor, and motor learning ( 72 ). Moreover, the fMRI findings also found activations in bilateral thalamocortical circuits are associated with affected hand motions after rTMS ( 35 ).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of fMRI activation in post-stroke patients with movement disorders after repetitive transcranial magnetic stimulation: a scoping review

et al. 2023

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BackgroundMovement disorders are one of the most common stroke residual effects, which cause a major stress on their families and society. Repetitive transcranial magnetic stimulation (rTMS) could change neuroplasticity, which has been suggested as an alternative rehabilitative treatment for enhancing stroke recovery. Functional magnetic resonance imaging (fMRI) is a promising tool to explore neural mechanisms underlying rTMS intervention.ObjectOur primary goal is to better understand the neuroplastic mechanisms of rTMS in stroke rehabilitation, this paper provides a scoping review of recent studies, which investigate the alteration of brain activity using fMRI after the application of rTMS over the primary motor area (M1) in movement disorders patients after stroke.MethodThe database PubMed, Embase, Web of Science, WanFang Chinese database, ZhiWang Chinese database from establishment of each database until December 2022 were included. Two researchers reviewed the study, collected the information and the relevant characteristic extracted to a summary table. Two researchers also assessed the quality of literature with the Downs and Black criteria. When the two researchers unable to reach an agreement, a third researcher would have been consulted.ResultsSeven hundred and eleven studies in all were discovered in the databases, and nine were finally enrolled. They were of good quality or fair quality. The literature mainly involved the therapeutic effect and imaging mechanisms of rTMS on improving movement disorders after stroke. In all of them, there was improvement of the motor function post-rTMS treatment. Both high-frequency rTMS (HF-rTMS) and low-frequency rTMS (LF-rTMS) can induce increased functional connectivity, which may not directly correspond to the impact of rTMS on the activation of the stimulated brain areas. Comparing real rTMS with sham group, the neuroplastic effect of real rTMS can lead to better functional connectivity in the brain network in assisting stroke recovery.ConclusionrTMS allows the excitation and synchronization of neural activity, promotes the reorganization of brain function, and achieves the motor function recovery. fMRI can observe the influence of rTMS on brain networks and reveal the neuroplasticity mechanism of post-stroke rehabilitation. The scoping review helps us to put forward a series of recommendations that might guide future researchers exploring the effect of motor stroke treatments on brain connectivity.

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Cerebellum and Emotion in Social Behavior

Cited by 7 publications

References 144 publications

Theory of mind profile and cerebellar alterations in remitted bipolar disorder 1 and 2: a comparison study

Theory of mind profile and cerebellar alterations in remitted bipolar disorder 1 and 2: a comparison study

Structural brain changes in emotion recognition across the adult lifespan

Evaluation of fMRI activation in post-stroke patients with movement disorders after repetitive transcranial magnetic stimulation: a scoping review

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