Cerebellum and processing of negative facial emotions: Cerebellar transcranial DC stimulation specifically enhances the emotional recognition of facial anger and sadness

Ferrucci, Roberta; Giannicola, Gaia; Rosa, Manuela; Fumagalli, Manuela; Boggio, Paulo S.; Hallett, Mark; Zago, Stefano; Priori, Alberto

doi:10.1080/02699931.2011.619520

Cited by 182 publications

(145 citation statements)

References 36 publications

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“…Cerebellar lesions have been known to be involved in pathological laughter and crying resulting from impaired emotional expression [20]. According to Ferrucci, et al the cerebellum is involved in processing facial expression of negative emotions [21]. Therefore, injury to the cerebellum may result in abnormalities in control of voluntary movements and decrease in living standard of people living with HIV.…”

Section: Discussionmentioning

confidence: 99%

Histomorphological effect of Lamivudine on the Cerebellum of Wistar rats

Peter¹,

Udoh²,

Ekanem³

2017

Histol Cytol Embryol

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Lamivudine is an anti-retroviral drug used for the treatment of HIV and hepatitis B. It is one of the essential medicines needed in a basic health system. This study was carried out to investigate the detrimental effect of lamivudine on the cerebellum based on the adverse effects of gait disorders manifested by patients using lamivudine. Twenty male Wistar rats divided into two groups of ten rats each were used for the study. Control group A was administered with 1ml of distilled water, while treatment group B was treated with 4.28mg/kg of lamivudine daily for 30 days. On the 30 th day, the rats were euthanized and each cerebellum was harvested immediately. The cerebella were put through routine tissue processing for H/E staining and GFAP immunohistochemical method. The resulting specimens were mounted with DPX and viewed under the light microscope at ×400. Photomicrographs showed shrunken Purkinje cells and distorted granular layer in the cerebellum of group B rats while those of group A rats were healthy. Also, image J counting showed reduced number of cells in the lamivudine group. This correlated with the higher staining intensity for GFAP in the granular layer of group B rats suggesting cellular inflammation and damage. More research is needed to ascertain the molecular mechanism of these distortions.

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Section: Discussionmentioning

confidence: 99%

Histomorphological effect of Lamivudine on the Cerebellum of Wistar rats

Peter¹,

Udoh²,

Ekanem³

2017

Histol Cytol Embryol

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“…Direct support of the hypothesis of cerebellar function in the conscious processing of emotional faces comes from stimulation studies that have observed a greater ability to recognize negative facial expressions after transcranial direct current stimulation (tDCS) is performed over the cerebellum [86].…”

Section: Cerebellar Involvement In the Conscious Component Of Emotionsmentioning

confidence: 98%

The Role of the Cerebellum in Unconscious and Conscious Processing of Emotions: A Review

et al. 2017

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Abstract:Studies from the past three decades have demonstrated that there is cerebellar involvement in the emotional domain. Emotional processing in humans requires both unconscious and conscious mechanisms. A significant amount of evidence indicates that the cerebellum is one of the cerebral structures that subserve emotional processing, although conflicting data has been reported on its function in unconscious and conscious mechanisms. This review discusses the available clinical, neuroimaging, and neurophysiological data on this issue. We also propose a model in which the cerebellum acts as a mediator between the internal state and external environment for the unconscious and conscious levels of emotional processing.

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“…Several reports have identified the cerebellum as recognizing and discriminating emotional facial expressions, in particular for negative emotions (Turner et al, 2007;Fusar-Poli et al, 2009;Ferrucci et al, 2012;Adamaszek et al, 2014). These observations suggest that in addition to its recognized motor tasks, the cerebellum is involved in the integration of emotional responses in social behaviors.…”

Section: Introductionmentioning

confidence: 96%