Cerebellum as Initial Site of Distant Metastasis from Papillary Carcinoma of Thyroid: Review of Three Cases

Tunio, Mutahir A.; Asiri, Mushabbab Al; Al‐Qahtani, Khalid; AlShakweer, Wafa

doi:10.1155/2015/171509

Cited by 3 publications

(4 citation statements)

References 12 publications

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“…In addition, it is extremely rare for cerebellar metastasis to occur as an initial distal metastasis of papillary carcinoma of the thyroid, only 16 cases have been published to date [4].…”

Section: Discussionmentioning

confidence: 99%

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Enormous Initial Cerebellar Metastasis Revealing Papillary Carcinoma of the Thyroid: Rare Case

Anajar¹,

Tatari²,

Hassnaoui³

et al. 2017

AJMCR

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Introduction: Papillary carcinoma is the most frequent differentiated malignant thyroid neoplasm.Metastasis occurs frequently in regional lymph nodes and remote metastasis are late and rare, only 16 cases of initial cerebellar metastasis have been reported in the literature. Results: We report a rare case of cerebellar metastasis revealing papillary thyroid carcinoma in a 32-year-old patient, with a review of the literature on clinical features, radiological aspect, and treatment options. Discussion Conclusion: Cerebral metastasis of thyroid cancer are rare and the initial cerebellar metastasis revealing papillary carcinoma are exceptional, and due to their rarities and the relative lack of data on their management there is no treatment algorithm clearly defined.

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“…In addition, it is extremely rare for cerebellar metastasis to occur as an initial distal metastasis of papillary carcinoma of the thyroid, only 16 cases have been published to date [4].…”

Section: Discussionmentioning

confidence: 99%

“…The presence of distant metastases is an element of poor prognosis associated with a decrease in survival rates [3]. Initial cerebellar metastases are extremely rare with about 16 cases reported in the literature [4]. We present an exceptional case of an enormous initial cerebellar metastasis revealing thyroid cancer.…”

Section: Introductionmentioning

confidence: 90%

Enormous Initial Cerebellar Metastasis Revealing Papillary Carcinoma of the Thyroid: Rare Case

Anajar¹,

Tatari²,

Hassnaoui³

et al. 2017

AJMCR

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“…Papillary thyroid carcinoma commonly metastasizes to regional lymph nodes, lungs, and bones, whereas the brain is an uncommon site of metastasis that is found in only 0.15–1.3 % of cases (Parker et al 1986 ; Tanaka et al 2013 ). Moreover, it is extremely rare for a cerebellar metastasis to occur as an initial distant metastasis of PTC, with only 16 such cases published to date (Tunio et al 2015 ). A brain metastasis of thyroid cancer could be a negative prognostic factor and the median survival in such cases were reported as 4.7 months (including anaplastic type 11 cases) (n = 47) (Chiu et al 1997 ), 9.4 months (n = 9) (Misaki et al 2000 ), 17.4 months (n = 16) (McWilliams et al 2003 ), for a maximum of 29.2 months (n = 9) (Kim et al 2009 ).…”

Section: Discussion and Evaluationmentioning

confidence: 99%

“…There are no characteristics of MRI or other radiographic abnormalities that distinguish metastatic lesions of thyroid carcinoma from other brain tumors (McWilliams et al 2003 ; Tunio et al 2015 ). There are only three cases in which findings in digital subtraction angiography have been described (Cha et al 2000 ; Hashiba et al 2006 ; Umehara et al 2015 ).…”

Section: Discussion and Evaluationmentioning

confidence: 99%

Metastatic cerebellar tumor of papillary thyroid carcinoma mimicking cerebellar hemangioblastoma

Ideguchi

Nishizaki²,

Ikeda³

et al. 2016

SpringerPlus

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IntroductionWell-differentiated papillary thyroid carcinoma generally (PTC) have a favorable prognosis. This metastasis is rare in the central nervous system. Brain metastasis has a relatively poor prognosis. We present a rare case of cerebellar metastasis, one that mimics a solid type cerebellar hemangioblastoma and because of which it was very hard to reach accurate preoperative diagnosis. Accurate diagnosis was challenging because of the similar imaging and histopathological findings for these two tumors.Case descriptionA brain lesion was detected by routine medical checkup of the brain with MRI in a 49-year-old woman 2 years after thyroidectomy for well-differentiated PTC. Gadolinium-enhanced MRI showed a homogeneous prominently enhanced lesion with surrounding enhanced dilated vessels in the left cerebellar hemisphere. Digital subtraction angiography showed a strongly stained lesion fed by the peripheral branch of the left posterior inferior cerebellar artery with drainage into the inferior vermian vein, revealing arteriovenous shunting. The most like likely preoperative diagnosis was felt to be that of a solid cerebellar hemangioblastoma. Gross total resection of the tumor was achieved by bilateral suboccipital craniotomy, and intraoperative pathological analysis suggested hemangioblastoma. Histopathological findings showed proliferation of vacuolated sheeted tumor cells with clear and eosinophilic cytoplasm and numerous thin-walled microvessels, consistent with hemangioblastoma. However, the final diagnosis was brain metastasis of the follicular variant of PTC due to a partial thyroid follicle-like pattern including eosinophilic fluid pathologically and positive TTF-1 immunostaining.Discussion and evaluationSince presented rare case of cerebellar metastasis of PTC was very similar to solid type cerebellar hemangioblastoma on imaging and histopathological findings, accurate diagnosis was challenging. Moreover, it is extremely rare for a cerebellar metastasis to occur as an initial distant metastasis of PTC, and hemangioblastoma is the most common primary cerebellar neoplasm in adults. This epidemiological data was also one of the reason of difficulty to reach preoperative accurate diagnosis.ConclusionsTo the best of our knowledge, there are no other reports of challenging diagnosis case of these two tumors in the literature. Brain metastasis of a well-differentiated PTC could be a relatively poor prognostic factor, and accurate diagnosis and suitable surgical therapy or radiotherapy are needed.

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Delayed brain metastasis after 17-years from papillary thyroid cancer without local recurrence: case report and literature review

Knight

Kingham

Price

et al. 2022

Journal of Surgical Case Reports

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Papillary thyroid carcinoma (PTC) is the most common malignancy originating from the thyroid, with a good overall prognosis. However, distant metastasis of such lesions is very rare, with the brain being an incredibly uncommon site for secondary spread. The authors report a case of PTC brain metastasis 17-years after successful treatment of the primary malignancy, with no local or locoregional recurrence. Initial diagnostic uncertainty necessitated the involvement of a multidisciplinary team, and eventually the patient underwent image-guided gross surgical resection with intraoperative neuromonitoring (IOMN).

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Cerebellum as Initial Site of Distant Metastasis from Papillary Carcinoma of Thyroid: Review of Three Cases

Cited by 3 publications

References 12 publications

Enormous Initial Cerebellar Metastasis Revealing Papillary Carcinoma of the Thyroid: Rare Case

Enormous Initial Cerebellar Metastasis Revealing Papillary Carcinoma of the Thyroid: Rare Case

Metastatic cerebellar tumor of papillary thyroid carcinoma mimicking cerebellar hemangioblastoma

Delayed brain metastasis after 17-years from papillary thyroid cancer without local recurrence: case report and literature review

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