Cerebral 18F-FDG metabolism alteration in a neuropathic pain model following brachial plexus avulsion: A PET/CT study in rats

Shen, Jun; Huo, Bei‐Bei; Hua, Xu‐Yun; Zheng, Mou‐Xiong; Lu, Ye-Chen; Wu, Jiajia; Shan, Chunlei; Xu, Jian‐Guang

doi:10.1016/j.brainres.2019.02.005

Cited by 9 publications

(11 citation statements)

References 43 publications

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“…On the other hand, the limbic system, including the hippocampus gyrus, is activated in pain processing [66]. The hippocampus is possibly involved in the formation of pain-associated memory and emotional responses [67,68]. Earlier researches have proposed that the sensory and limbic networks of pain are parallel and independent [25].…”

Section: Altered Functional Connectivity Of Insulamentioning

confidence: 99%

The Reorganization of Insular Subregions in Individuals with Below-Level Neuropathic Pain following Incomplete Spinal Cord Injury

Chen

et al. 2020

Neural Plasticity

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Objective. To investigate the reorganization of insular subregions in individuals suffering from neuropathic pain (NP) after incomplete spinal cord injury (ISCI) and further to disclose the underlying mechanism of NP. Method. The 3D high-resolution T1-weighted structural images and resting-state functional magnetic resonance imaging (rs-fMRI) of all individuals were obtained using a 3.0 Tesla MRI system. A comparative analysis of structure and function connectivity (FC) with insular subareas as seeds in 10 ISCI individuals with below-level NP (ISCI-P), 11 ISCI individuals without NP (ISCI-N), and 25 healthy controls (HCs) was conducted. Associations between the structural and functional alteration of insula subregions and visual analog scale (VAS) scores were analyzed using the Pearson correlation in SPSS 20. Results. Compared with ISCI-N patients, when the left posterior insula as the seed, ISCI-P showed increased FC in right cerebellum VIIb and cerebellum VIII, Brodmann 37 (BA 37). When the left ventral anterior insula as the seed, ISCI-P indicated enhanced FC in right BA18 compared with ISCI-N patients. These increased FCs positively correlated with VAS scores. Relative to HCs, ISCI-P presented increased FC in the left hippocampus when the left dorsal anterior insula was determined as the seed. There was no statistical difference in the volume of insula subregions among the three groups. Conclusion. Our study indicated that distinctive patterns of FC in each subregion of insula suggest that the insular subareas participate in the NP processing through different FC following ISCI. Further, insula subregions could serve as a therapeutic target for NP following ISCI.

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Section: Altered Functional Connectivity Of Insulamentioning

confidence: 99%

The Reorganization of Insular Subregions in Individuals with Below-Level Neuropathic Pain following Incomplete Spinal Cord Injury

Chen

et al. 2020

Neural Plasticity

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“…The present study focused on the effects of EA on brain metabolism following BPAI-induced neuropathic pain. The feasibility of the BPAI-induced neuropathic pain model was already confirmed in our previous studies, 19 we did not include a sham surgery group.…”

Section: Methods Animalsmentioning

confidence: 84%

“…48 We also used small animal PET/CT to explore metabolism in the brain-related BPAI-induced neuropathic pain. 19 In the present study, the changes of brain in EA-treated neuropathic pain rats were detected using PET/CT scans. Both the immediate and aftereffects of the metabolic mechanisms were investigated.…”

Section: Discussionmentioning

confidence: 90%

“…32 Flor et al reported that neuropathic pain due to amputation was related to expansion of the adjacent region, 12,50 which was consistent with our previous research. 19,51 Studies also revealed that cortical changes were not restricted to the sensorimotor cortex, but also an involved extensive range of areas, including the thalamus, anterior insula, and others. [52][53][54] The thalamus is the main relay of sensory and spinal nerve pathways (spinothalamic tract), which is important for the development of deafferentation pain.…”

Section: Discussionmentioning

confidence: 99%

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<p>Brain Metabolism in Rats with Neuropathic Pain Induced by Brachial Plexus Avulsion Injury and Treated via Electroacupuncture</p>

Huo

Zheng

Hua

et al. 2020

JPR

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These authors contributed equally to this workPurpose: Brain organisation is involved in the mechanism of neuropathic pain. Acupuncture is a common clinical practise in traditional Chinese medicine for the treatment of chronic pain. This study explored electroacupuncture's effects on brain metabolism following brachial plexus avulsion injury (BPAI)-induced pain. Methods: A total of 32 female rats were randomised into a normal group, model group, sham electroacupuncture group, and electroacupuncture group. A pain model was included via right BPAI. The electroacupuncture intervention at cervical "Jiaji" points (C5-7) was performed for 11 weeks. The mechanical withdrawal threshold of the non-injured (left) forepaw was measured at the baseline and on days 3, 7, 14, 21, 28, 56, 84, and 112 subsequent to BPAI. Positron emission tomography (PET) was applied to explore metabolic changes on days 28, 84, and 112. Results: After electroacupuncture, the mechanical withdrawal threshold of the left forepaws was significantly elevated and the effect persisted until 4 weeks after the intervention ceased (p<0.05 or p<0.001). In the sensorimotor-related brain regions, standardised uptake values in the bilateral somatosensory and motor cortices were observed in the electroacupuncture group. Metabolism particularly increased in the right somatosensory cortex. Metabolism changes also occurred in the pain-related brain regions and emotion-and cognition-related brain regions. Conclusion:The present study demonstrated the beneficial effects of electroacupuncture for relieving BPAI-induced neuropathic pain in rats. Electroacupuncture intervention might inhibit maladaptive plasticity in brain areas governing multidimensional functions, especially in sensorimotor-and cognition-related cortices.

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“…The global BPAI (C5-T1 cervical nerve roots) procedure was performed on the right side in the rats of model, sham EA, and EA groups according to the method described in our previous study (Shen et al, 2019a). During the procedure, the rat was anesthetized via intraperitoneal injection with sodium pentobarbital (40 mg/kg) and then placed in a prone position on a clean operation table.…”

Section: Surgical Proceduresmentioning

confidence: 99%

Electroacupuncture-Related Metabolic Brain Connectivity in Neuropathic Pain due to Brachial Plexus Avulsion Injury in Rats

Hou

Zheng

Hua

et al. 2020

Front. Neural Circuits

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Objective: The present study aimed to investigate the analgesic effect of electroacupuncture (EA) in neuropathic pain due to brachial plexus avulsion injury (BPAI) and related changes in the metabolic brain connectivity. Methods: Neuropathic pain model due to BPAI was established in adult female Sprague-Dawley rats. EA stimulations (2/15 Hz, 30 min/day, 5-day intervention followed by 2-day rest in each session) were applied to the fifth-seventh cervical "Jiaji" acupoints on the noninjured side from 1st to 12th weeks following BPAI (EA group, n = 8). Three control groups included sham EA (nonelectrical acupuncture applied to 3 mm lateral to the real "Jiaji" acupoints), BPAI-only, and normal rats (no particular intervention; eight rats in each group). Thermal withdrawal latency (TWL) of the noninjured forepaw was regularly tested to evaluate the threshold of thermalgesia. Small animal [fluorine-18]fluoro-2-deoxy-D-glucose (18 F-FDG) PET/CT scans of brain were conducted at the end of 4th, 12th, and 16th weeks to explore metabolic alterations of brain. Results: In the EA group, the TWL of the noninjured forepaw significantly decreased following BPAI and then increased following EA stimulation, compared with sham EA (P < 0.001). The metabolic brain connectivity among somatosensory cortex (SC), motor cortex (MC), caudate putamen (Cpu), and dorsolateral thalamus (DLT) in bilateral hemispheres decreased throughout the 16 weeks' observation in the BPAI-only group, compared with the normal rats (P < 0.05). In the EA group, the strength of connectivity among the above regions were found to be increased at the end of 4th week following BPAI modeling, decreased at 12th week, and then increased again at 16th week (P < 0.05). The changes in metabolic connectivity were uncharacteristic and dispersed in the sham EA group. Conclusion: The study revealed long-term and extensive changes of metabolic brain connectivity in EA-treated BPAI-induced neuropathic pain rats. Bilateral sensorimotor

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Cerebral 18F-FDG metabolism alteration in a neuropathic pain model following brachial plexus avulsion: A PET/CT study in rats

Cited by 9 publications

References 43 publications

The Reorganization of Insular Subregions in Individuals with Below-Level Neuropathic Pain following Incomplete Spinal Cord Injury

The Reorganization of Insular Subregions in Individuals with Below-Level Neuropathic Pain following Incomplete Spinal Cord Injury

<p>Brain Metabolism in Rats with Neuropathic Pain Induced by Brachial Plexus Avulsion Injury and Treated via Electroacupuncture</p>

Electroacupuncture-Related Metabolic Brain Connectivity in Neuropathic Pain due to Brachial Plexus Avulsion Injury in Rats

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