Cerebral amyloid angiopathy. A critical review.

Vinters, Harry V.

doi:10.1161/01.str.18.2.311

Cited by 971 publications

(751 citation statements)

References 199 publications

Supporting

Mentioning

710

Contrasting

Unclassified

Order By: Relevance

“…These structural changes of the affected vessels are important as contributing factors in the development of CAA-ICH and are collectively called CAAassociated vasculopathy. 3 These pathological changes are also observed in patients with cerebral SVD resulting from arteriosclerotic diseases such as hypertension or diabetes mellitus. 22 In the past, the development of CAA had not been thought to correlate with the presence of common cerebrovascular risk factors, including hypertension, diabetes mellitus, hyperlipidemia, or the severity of atherosclerosis of the cerebral arteries.…”

Section: Relationship Between Caa-ich and Hypertensionmentioning

confidence: 95%

“…An autopsy series reported that the prevalence of CAA over the age of 70 years was 43%, and almost half of the cases were estimated to have moderate-to-severe CAA. 3 The prevalence of hypertension also increases with the age. The prevalence of hypertension at age 50 is about 30% and 20% in the United States and Canada, respectively, and it increases to about 60% and 50% at age 70.…”

Section: Relationship Between Caa-ich and Hypertensionmentioning

confidence: 99%

“…[1][2][3][4] The incidence of CAA increases with age. Approximately half of elderly people (aged 60 years and older) and 74% of the individuals aged 90 years and older are affected with CAA.…”

Section: Introductionmentioning

confidence: 99%

“…[4][5][6] CAA leads to multiple cortico-subcortical or lobar hemorrhages in the elderly, and it is then referred to as CAA-related intracerebral hemorrhage (CAA-ICH). 3,7 Boston criteria were established for CAA-ICH by the Boston Cerebral Amyloid Angiopathy Group, and a definite diagnosis of CAA-ICH can be formulated only by demonstrating lobar or cortico-subcortical hemorrhage and severe CAA with vasculopathy after whole histological investigation of affected brain tissue is obtained at autopsy. 8,9 Biopsy of the evacuated hematoma or cerebral cortex contributes to premortem diagnosis of probable CAA-ICH with supporting pathology; however, the positive ratio of amyloid deposition in the specimens obtained from brain biopsy or hematoma evacuation has not been investigated enough.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Clinico-Radiological Characteristics and Pathological Diagnosis of Cerebral Amyloid Angiopathy-Related Intracerebral Hemorrhage

Doden

Sato

Sasahara

et al. 2016

Journal of Stroke and Cerebrovascular Diseases

View full text Add to dashboard Cite

Objective: We aim to clarify the clinico-radiological characteristics of cerebral amyloid angiopathy-related intracerebral hemorrhage and to investigate the efficacy of pathological diagnosis using biopsy specimens. Method: We retrospectively reviewed 253 consecutive patients with cortico-subcortical hemorrhage who had been admitted to Aizawa Hospital between January 2006 and July 2013. We had performed craniotomy and hematoma evacuation in 48 patients, as well as biopsy of the evacuated hematoma, cerebral parenchyma adjacent to the hematoma, or both, and they were classified according to the histological results (positive or negative for vascular amyloid deposition) and to the Boston criteria. We compared the clinicoradiological characteristics of cerebral amyloid angiopathy-related intracerebral hemorrhage. We also investigated the detection rate of cerebral amyloid angiopathy with respect to the origins of the specimens. Results: Pathological examination revealed that 22 subjects were positive for vascular amyloid. The number of the cerebral microbleeds located in the deep or infratentorial region was significantly larger in the negative group than in the positive group (P < .05). There was no significant difference in the distribution of lobar cerebral microbleeds and in the prevalence of hypertension. In the probable cerebral amyloid angiopathyrelated intracerebral hemorrhage patients, the probability of having vascular amyloid detected by biopsy of both hematoma and parenchyma was 100%. Rebleeding in the postoperative periods was observed in 2 cases (9.1%) of the positive group.Conclusions: Our results demonstrate the importance and safety of biopsy simultaneously performed with hematoma evacuation. Deep or infratentorial microbleeds are less correlated with cerebral amyloid angiopathy-related intracerebral hemorrhage than with noncerebral amyloid angiopathy-related intracerebral hemorrhage.

show abstract

Section: Relationship Between Caa-ich and Hypertensionmentioning

confidence: 95%

Section: Relationship Between Caa-ich and Hypertensionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Clinico-Radiological Characteristics and Pathological Diagnosis of Cerebral Amyloid Angiopathy-Related Intracerebral Hemorrhage

Doden

Sato

Sasahara

et al. 2016

Journal of Stroke and Cerebrovascular Diseases

View full text Add to dashboard Cite

show abstract

“…These amyloid deposits are similar to those seen in Alzheimer's disease. The amyloid-beta fragment is the primary component of the plaques [18,19].…”

Section: Cerebral Amyloid Angiopathymentioning

confidence: 99%

Treatment Targets in Intracerebral Hemorrhage

Sangha

Gonzales

2011

Neurotherapeutics

View full text Add to dashboard Cite

Intracerebral hemorrhage (ICH) imparts a higher mortality and morbidity than ischemic stroke. The therapeutic interventions that are currently available focus mainly on supportive care and secondary prevention. There is a paucity of evidence to support any one acute intervention that improves functional outcome. This chapter highlights current treatment targets for ICH based on the pathophysiology of the disease.

show abstract