Cerebral Amyloid Angiopathy and Cerebral Amyloid Angiopathy-Related Inflammation: Comparison of Hemorrhagic and DWI MRI Features

Abstract

Compared to CAA, CAA-ri was associated with higher CMB numbers, more frequent ApoE4 carriers and homozygotes, lower CSF Aβ42 levels, and more severe amyloid load on FBB-PET.

PET imaging for the evaluation of cerebral amyloid angiopathy: a systematic review

“…Regarding the device used for scan acquisition, 8 studies used PET only [17][18][19][20][21][22][23][24], 17 studies used PET/CT [25-32, 34-37, 39, 40, 42-45] while 3 studies used PET/ MR [33,38,41]. Speaking about radiotracer, 11 C-PIB was used in 13 studies [17-22, 28, 31, 32, 37, 41, 42, 45], 5 studies used 18 F-florbetapir [25,30,33,35,36], 18 F-FDG was used in 3 studies [23,39,40], 18 F-florbetaben ( 18 F-FBB) was used in 2 studies [26,27] and 18 F-flutemetamol was used in one study [38]. Furthermore, some works used more than one tracer and in particular, a study used a combination of 18 F-florbetapir and 11 C-PIB [24], a study was performed with 11 C-PIB and 18 F-FBB [29], a study with 11 C-PIB and 18 F-T807 [43], a study with 11 C-PIB and 18 F-flortaucipir [44] and lastly a study used a combination of three different tracer ( 11 C-PIB, 18 F-FBB and 18 F-flutemetamol) [34].…”

“…Three works investigated the role of 18 F-FDG imaging in CAA [23,39,40], revealing its capability to differentiate between CAA-related and CAA-unrelated CMB [23] and between CAA and AD [40]. Furthermore, the value of 18 F-FBB PET imaging was investigated by two works, demonstrating its ability to differentiate CAArelated inflammation (CAA-ri) from CAA and, with less evidences, from normal controls [26,27].…”

“…First, the group by Raposo et al [25,26] reported greater cortical 18 F-florbetapir retention for CAA patients than deep ICH patients and a higher ratio of positive PET scan for lobar ICH than deep ICH. Furthermore, among CAA patients the highest uptake was present in the occipital lobe and a value of 1.18 for global SUVR (standardized uptake value ratio with cerebellum as reference) was obtained.…”

“…The role of 18 F-FBB in CAA was evaluated in two studies by the group Renard et al [26,27]. They reported general higher tracer uptake for CAA-ri patients compared to normal control, in particular in the occipital lobe with a posterior to anterior trend, however, without significant difference between the lobes.…”

Clinical applications of diffusion-weighted sequence in brain imaging: beyond stroke

“…CAA can be associated with vasculitis, which is termed CAA-related inflammation (CAA-ri). DWI changes are more likely to be associated with CAA-ri [83].…”