Cerebral amyloid angiopathy presenting with neuropsychiatric symptoms

Gleason, Andrew; Hayhow, Brad; Emmanuel, Jaiman; Gaillard, Frank

doi:10.1177/0004867414525843

Cited by 8 publications

(4 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The cognitive impairment of SCAA through hemorrhagic and ischemic pathomechanisms comprises mainly memory, executive functions and perceptual speed [15]; it may progress to MCI [16] and eventually to dementia [10]. Prominent psychopathology may also be present in SCAA [17,18]. SCAA appears as a distinct cerebrovascular condition, or comorbid with AD [19,20], Here we report a case of SCAA whose striking behavioral abnormalities and neuropsychological test results closely resembled bvFTD.…”

Section: Introductionmentioning

confidence: 81%

“…However, in addition to bvFTD and atypical AD [29,40]. SCAA appears to be an important differential diagnosis in patients with progressive neuropsychiatric symptoms and executive impairment [17,18,41]. The diagnosis of SCAA is crucial and can have essential therapeutic consequences with regard to thrombolytic or anticoagulation therapy [42,43] blood pressure control [44] and prognosis due to their risk of further spontaneous brain hemorrhages and consequent dementia [45].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Cerebral Amyloid Angiopathy or Frontotemporal Dementia? A Case Study

Benke¹,

Scherfler²,

Karner³

et al. 2017

J Alzheimers Dis Parkinsonism

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Cerebral Amyloid Angiopathy or Frontotemporal Dementia? A Case Study

Benke¹,

Scherfler²,

Karner³

et al. 2017

J Alzheimers Dis Parkinsonism

View full text Add to dashboard Cite

“…However, another possibility would be that CAA itself presented with a dementia resembling DLB. Not infrequently, CAA patients develop a frontal-subcortical type of cognitive impairment [25], and/or visuospatial dysfunction [26] and/or behavioral-psychiatric symptoms [27]. Indeed, in a small series of patients with CAA we have observed that patients who present in cognitive disorder departments more commonly have a non-amnestic dementia phenotype, whereas clinically evident hemorrhagic events are rare, while 17% of these patients present with DLB-like features [28].…”

Section: Discussionmentioning

confidence: 99%

Mixed Small Vessel Disease in a Patient with Dementia with Lewy Bodies

et al. 2019

View full text Add to dashboard Cite

Background: Cerebral amyloid angiopathy (CAA) is characterized by deposition of amyloid in small/medium size brain vessels, and may coexist with Alzheimer’s disease or dementia with Lewy bodies (DLB). We describe a patient with a clinical diagnosis of DLB and imaging/biochemical characteristics suggestive of mixed small vessel disease (both CAA and non-amyloid microangiopathy). Methods: Clinical evaluation according to recent diagnostic criteria, magnetic resonance imaging, dopamine-transporter scan (DAT-scan) and cerebrospinal fluid (CSF) analysis for dementia biomarkers were all performed. Results: The patient is a 71-year-old male, fulfilling criteria for probable DLB, with a positive DAT-scan, but with multiple microbleeds in a cortical-subcortical location suggestive of CAA, some microbleeds in deep brain nuclei suggestive of non-amyloid microangiopathy and abnormal levels of only amyloid-beta (Aβ42) in CSF. Conclusion: Coexistent mixed vascular and neurodegenerative disorders are frequent in older subjects with dementia and each one of the underlying pathologies may contribute to, or modify the clinical presentation.

show abstract

“…While the relationship between CAA and cognitive impairment has been relatively well established within the current literature [2][3][4], minimal work has investigated the neuropsychiatric symptom (NPS) profile of CAA. Three case reports have reported depression, irritability, aggression, and personality changes in patients with CAA [5][6][7]. Hallucinations and delusions were also associated with advanced CAA in patients with AD or Lewy Body disease that was diagnosed with autopsy [8].…”

Section: Introductionmentioning

confidence: 99%

Severe Neuropsychiatric Symptoms in Multiple Cerebral Microbleeds due to Probable Cerebral Amyloid Angiopathy: A Case Study

2023

Ann Case Report

View full text Add to dashboard Cite

Multiple cerebral microhemorrhages are a common feature of cerebral amyloid angiopathy (CAA), a cerebrovascular disorder contributing to cognitive impairment. While CAA-related cognitive and functional deterioration has been wellestablished within the literature, emerging work suggests that neuropsychiatric symptoms (NPS), such as depression, behavioural issues, and personality changes, are clinical manifestations of the disorder. Recent seminal work has revealed that patients with probable CAA were shown to experience various NPS, especially depression and emotional dysregulation, at a greater frequency and severity than healthy controls. Additionally, a significant association has been demonstrated between severe psychotic symptoms and advanced CAA in autopsied individuals with Alzheimer's disease. In this report, we present a case of probable CAA that highlights severe NPS within the disorder. A 72-year-old male was admitted into a local hospital to stabilize behavioural and psychological symptoms after revealing suicidal ideation to a former partner due to the state of his financial affairs. Past medical and psychiatric history revealed a three-year history of cognitive decline, long-standing personality changes, and multiple suicide attempts, with comorbidities of probable CAA, depression, and alcohol use disorder. He underwent neuropsychological testing, where he performed poorly across several cognitive domains assessed, demonstrating markedly poor executive function, processing speed, and memory. Neuroimaging revealed severe chronic microangiopathy, mild-tomoderate generalized volume loss, and multiple cerebral microhemorrhages. While the current case aligns with the reviewed literature findings, the observed suicidal behaviour, and vulnerability to financial exploitation suggest careful reconsideration of the clinical manifestations of CAA.

show abstract

Cerebral amyloid angiopathy presenting with neuropsychiatric symptoms

Cited by 8 publications

References 6 publications

Cerebral Amyloid Angiopathy or Frontotemporal Dementia? A Case Study

Cerebral Amyloid Angiopathy or Frontotemporal Dementia? A Case Study

Mixed Small Vessel Disease in a Patient with Dementia with Lewy Bodies

Severe Neuropsychiatric Symptoms in Multiple Cerebral Microbleeds due to Probable Cerebral Amyloid Angiopathy: A Case Study

Contact Info

Product

Resources

About