2016
DOI: 10.1016/j.neubiorev.2016.01.004
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Cerebral amyloid-β accumulation and deposition following traumatic brain injury—A narrative review and meta-analysis of animal studies

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Cited by 39 publications
(28 citation statements)
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“…Several human studies, however, have shown that APOE4 had no effect on outcome of TBI [12,49]. In contrast, the majority of animal studies, mostly in AD mouse models expressing human APP, have demonstrated APOE4 plays a significant role in determining the pathology and recovery following TBI, possibly in an age dependent manner [5,45,7]. The animal models of TBI obviously do not, and cannot, represent all aspects of brain pathology as a response to brain trauma at molecular, cellular and organ levels.…”
Section: Discussionmentioning
confidence: 99%
“…Several human studies, however, have shown that APOE4 had no effect on outcome of TBI [12,49]. In contrast, the majority of animal studies, mostly in AD mouse models expressing human APP, have demonstrated APOE4 plays a significant role in determining the pathology and recovery following TBI, possibly in an age dependent manner [5,45,7]. The animal models of TBI obviously do not, and cannot, represent all aspects of brain pathology as a response to brain trauma at molecular, cellular and organ levels.…”
Section: Discussionmentioning
confidence: 99%
“…These processes promoted the clearance of macromolecular metabolites from the brain, during sleep ( 15 ). The disturbance of glymphatic transport due to inadequate sleep may mediate neuropathologies in AD, given that sleep disruption aggravates the assembly of Aβ plaques and tangles ( 119 , 120 ). Recent studies have focused on the effect of sleep deprivation on synaptic plasticity and on structural changes of brain regions related to learning and memory ( 121 , 122 ), and the progression of AD ( 123 125 ).…”
Section: The Importance Of Sleep In Diabetes-induced Dementiamentioning
confidence: 99%
“…Notably, this effect was seen after inhibition of cholinergic as well as adrenergic and serotonergic pathways in rats (through chemical lesions in the nucleus basalis of Meynert, the ascending noradrenergic bundle and the dorsal raphe nucleus, respectively). Formation of Aβ as one consequence of such APP induction has been widely confirmed in experimental traumatic brain injury (Bird et al, 2016). Related findings have been made in humans, where APP has been used as early marker of axonal damage after mechanical trauma (Sherriff et al, 1994).…”
Section: Amyloid and Tau Pathology Are Common In Many Cns Disordersmentioning
confidence: 86%