Cerebral Amyloidoma Diagnosed Intraoperatively with Squash Preparations

Meir, Karen; Maly, Bella; Shoshan, Yigal; Maly, Alexander; Soffer, Dov

doi:10.1159/000326133

Cited by 9 publications

(5 citation statements)

References 10 publications

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“…Nevertheless, this tumor-like lesion seems not to be self-limiting as other localized AL-amyloidoma, but has the potency of further progression [18,24], but probably not the potency of recurrence after complete resection [21]. This observation supports the hypothesis that the amyloid protein or its components is synthesized adjacent to the deposits [10,12,46] and with a complete surgical removal the origin cells can be removed, too.…”

Section: Treatment and Prognosissupporting

confidence: 63%

“…Especially in all patients in whom tumor resection was performed, no tumor recurrence occurred, whereas MRI in patients after biopsy revealed a tumor progression in three out of eight cases (patients 9, 26, 27) with documented follow-up, in one of them with a doubling of tumor size [24].…”

Section: Neuroimaging Featuresmentioning

confidence: 85%

“…Epileptic seizure was the initial symptom in 10 cases (patients 2,9,10,12,16,18,[22][23][24]27); hemiparesis (patients 13,15,19,20,21,27) or gait disturbance (patient 11) occurred as first complaint in seven cases. In four patients (patients 3, 5, 6, 8), impairment of visual function was documented, as often as cognitive disturbance (patients 4, 14, 17, …”

Section: Clinical Symptomsmentioning

confidence: 99%

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Cerebral AL λ-amyloidoma: Clinical and pathomorphological characteristics. Review of the literature and of a patient

Fischer¹,

Palkovic²,

Rickert³

et al. 2007

Amyloid

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Section: Treatment and Prognosissupporting

confidence: 63%

Section: Neuroimaging Featuresmentioning

confidence: 85%

Section: Clinical Symptomsmentioning

confidence: 99%

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Cerebral AL λ-amyloidoma: Clinical and pathomorphological characteristics. Review of the literature and of a patient

Fischer¹,

Palkovic²,

Rickert³

et al. 2007

Amyloid

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“…However, a progression in the size of the lesion was noted [18]. It has the potential for further progression in size if left unresected [5,19] but usually does not recur after complete resection [20].…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Cerebral Amyloidoma Mimicking a Hemorrhagic Malignant Central Nervous System Neoplasm

Kapoor

Gowda

Kaur

et al. 2020

Cureus

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Cerebral amyloidoma is a rare form of amyloidosis with a localized tumor like an amyloid deposition in the brain composed of insoluble fibrillary protein with cross beta-sheet conformation. Its usual presentation includes vision loss, seizures, behavioral changes, cognitive decline, and recurrent headaches. It has a benign course with a slow progression, and it is not associated with dissemination. We report a case of a 65-year-old Caucasian woman who presented with symptoms of progressively worsening cognitive dysfunction of six months' duration. From CT of the brain, it was found that she had a right frontal and left parietal hemorrhagic mass with a large amount of vasogenic edema and a midline shift. MRI showed heterogeneously enhancing hemorrhagic mass of 5.2 cm x 2.6 cm x 3.6 cm in size, with a satellite lesion. Initially, this was suspected to be a high-grade glioma vs. metastatic hemorrhagic lesions. She underwent stereotactic biopsy of the mass, and histopathology was consistent with cerebral amyloidoma with marked IgA lambda plasma cell differentiation. She did not have any evidence of systemic amyloidosis, and therefore, she is being clinically observed with a regular follow-up and annual CT surveillance. She has remained stable over the past two years, although she has residual cognitive dysfunction. Cerebral amyloidoma can mimic malignant central nervous system (CNS) neoplasms and should be considered as a differential of any single or multiple mass lesions occurring in the white matter region of the brain with a characteristic appearance of "hyperdense lesions" on CT. It is a benign disease with no metastatic potential that usually resolves entirely after resection.

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“…Because some amyloidomas have recurred after surgical resection [29] and biopsied lesions have shown growth with [36] [38] [53] or without clinical wors-ening [17] [20] [41] [47] brain radiation therapy is another way to be considered as in some cases it provided disease control [8] [38] [44] [50].…”

Section: Managementmentioning

confidence: 99%

Brain Amyloidoma: Case Report and Literature Review

Moumouni¹,

Zolo²,

Kpelao³

et al. 2020

OJMN

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Introduction: Primary deposition of amyloid can take several forms including amyloidoma organ restricted among which is brain. Brain amyloidoma can mimic several lesions and offers a diagnostic challenge to the physician. The present work reports an additional case and summarizes the salient characteristics of previously published cases. Case Report: A 61-year-old, woman experienced paroxystic auditory hallucinations followed at times by generalized tonico-clonic seizures. Examination revealed a mild left pyramidal weakness. Head CT scan and MRI revealed a lobular lesion of the right atrium with contrast enhancement. The diagnosis of amyloidoma Lambda light chain (λLC) type was performed by means of a stereotactic biopsy. The patient was treated by 3 cures of high dose methotrexate (15 mg/m 2 ). At 24 months follow up the patient remains stable clinically and biologically. The 2 years follow-up MRI showed the same findings. Conclusion: No guidelines can be suggested for brain amyloidoma treatment; the "wait and see" was the mind-set in the literature. However, a non-tumour like pattern of a cerebral mass developing near the ventricle with a fine, irregular radiating margin enhancement and lack of oedema, and mass effect are important MRI clues for brain amyloidoma diagnosis. The diagnosis is histological after biopsy or excision.

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Cerebral Amyloidoma Diagnosed Intraoperatively with Squash Preparations

Cited by 9 publications

References 10 publications

Cerebral AL λ-amyloidoma: Clinical and pathomorphological characteristics. Review of the literature and of a patient

Cerebral AL λ-amyloidoma: Clinical and pathomorphological characteristics. Review of the literature and of a patient

A Rare Case of Cerebral Amyloidoma Mimicking a Hemorrhagic Malignant Central Nervous System Neoplasm

Brain Amyloidoma: Case Report and Literature Review

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