Cerebral anatomical changes in female asthma patients with and without depression compared to healthy controls and patients with depression

Wang, Lan; Wang, Ting; Liu, Shouzhi; Liang, Zong-An; Meng, Yajing; Xiong, Xingyu; Yang, Yinyin; Lui, Su; Ji, Yulin

doi:10.3109/02770903.2014.927482

Cited by 23 publications

(10 citation statements)

References 30 publications

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“…This could lead to further activity limitations and non-adherence to medicines, which then results in poor asthma outcomes. Furthermore, in our recently published magnetic resonance imaging and voxel-based morphometry study, we reported structural changes in the right superior temporal gyrus in female asthma patients with depression, and reduced gray matter volume in the right superior temporal gyrus was associated with increased airway hyperresponsiveness (34). This suggests that the right superior temporal gyrus may play a critical role in the link between asthma and depression.…”

Section: Discussionmentioning

confidence: 79%

Co-morbid psychological dysfunction is associated with a higher risk of asthma exacerbations: a systematic review and meta-analysis

Zhang

Zheng³

et al. 2016

J. Thorac. Dis.

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Background:The longitudinal associations between psychological dysfunction (PD) and asthma exacerbations (AE) have not been adequately addressed. This study aimed to systematically assess the influence of PD on AE, and to determine whether different PD affects AE differentially. P<0.001], presenting as hospitalizations (RR adj =1.22, 95% CI: 1.12-1.34, P<0.001), unscheduled doctor visits (RR =4.26, 95% CI: 2.52-7.19), and emergency department (ED) visits (RR adj =1.06, 95% CI: 1.01-1.10, P=0.009) because of asthma. Depression significantly increased the risk of AE (RR adj =1.07, 95% CI: 1.04-1.11, P<0.001), presenting as hospitalizations (RR adj =1.26, 95% CI: 1.07-1.49, P=0.007) and ED visits (RR adj =1.06, 95% CI: 1.02-1.11, P=0.007) because of asthma. Anxiety was only associated with an increased risk of AE in pregnant women (RR =1.05, 95% CI: 1.01-1.08), possibly due to the small amount of data available on anxiety. The influence of PD on AE was only significant when the PD exposure time exceeded one year.Conclusions: Co-morbid PD adversely affects AE, and there are differential effects of depression and anxiety. Asthmatic subjects with PD may benefit from more attention when establishing a treatment regimen in clinical practice.

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Section: Discussionmentioning

confidence: 79%

Co-morbid psychological dysfunction is associated with a higher risk of asthma exacerbations: a systematic review and meta-analysis

Zhang

Zheng³

et al. 2016

J. Thorac. Dis.

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“…The inflammatory response associated with atopic diseases is thought to affect the neurocircuitry including those involved in speech [ 172 , 173 ]. Markedly, adults with asthma show atypical gray [e.g., increased gray matter volume in the right superior temporal gyrus; 174 ], and white [e.g., lower white matter coherence in the inferior frontal gyrus; 175 ] matter in regions involved in speech production and reported to be affected in stuttering [ 176 ]. Although the mechanism of causality is unclear, the relationship between atopic diseases and stuttering, suggests that research on the impact of childhood health outcomes and stuttering is warranted.…”

Section: Discussionmentioning

confidence: 99%

Associations between stuttering, comorbid conditions and executive function in children: a population-based study

2020

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Background The aim of this study was to investigate the relationship between executive function (EF), stuttering, and comorbidity by examining children who stutter (CWS) and children who do not stutter (CWNS) with and without comorbid conditions. Data from the National Health Interview Survey were used to examine behavioral manifestations of EF, such as inattention and self-regulation, in CWS and CWNS. Methods The sample included 2258 CWS (girls = 638, boys = 1620), and 117,725 CWNS (girls = 57,512; boys = 60,213). EF, and the presence of stuttering and comorbid conditions were based on parent report. Descriptive statistics were used to describe the distribution of stuttering and comorbidity across group and sex. Regression analyses were to determine the effects of stuttering and comorbidity on EF, and the relationship between EF and socioemotional competence. Results Results point to weaker EF in CWS compared to CWNS. Also, having comorbid conditions was also associated with weaker EF. CWS with comorbidity showed the weakest EF compared to CWNS with and without comorbidity, and CWS without comorbidity. Children with stronger EF showed higher socioemotional competence. A majority (60.32%) of CWS had at least one other comorbid condition in addition to stuttering. Boys who stutter were more likely to have comorbid conditions compared to girls who stutter. Conclusion Present findings suggest that comorbidity is a common feature in CWS. Stuttering and comorbid conditions negatively impact EF.

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“…56 The mechanisms responsible for depression worsening asthma outcomes are not clearly established, and may relate to inflammation, cerebral anatomic changes, autonomic nervous dysfunction, decreased adherence, or ineffective self-management behaviors. 57…”

Section: Unique Factors That Can Complicate Asthma Management Among Omentioning

confidence: 99%

Asthma Over the Age of 65: All's Well That Ends Well

Baptist

Busse

2018

The Journal of Allergy and Clinical Immunology: In Practice

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Asthma in older adults (often classified as those 65 years or older) is relatively common, underdiagnosed, and suboptimally treated. It is an important health problem, as the population of the United States continues to age. Unfortunately, asthma morbidity and mortality rates are highest in this age group. Alterations in the innate and adaptive immune responses occur with aging, and contribute to pathophysiologic differences and subsequent treatment challenges. The symptoms of asthma may differ from those in younger populations, and often include fatigue. There are unique factors that can complicate asthma management among older adults, including comorbidities, menopause, caregiver roles, and depression. Pharmacologic therapies are often not as effective as in younger populations, and may have greater side effects. Spirometry, peak flow measurements, and asthma education are typically underused, and may contribute to delays in diagnosis as well as worse outcomes. There are specific strategies that health care providers can take to improve the care of older adults with asthma.

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Cerebral anatomical changes in female asthma patients with and without depression compared to healthy controls and patients with depression

Abstract: Current findings provided convergent evidence to support the critical role of the right STG in the brain mechanism that mediates asthma and depression.

Cited by 23 publications

References 30 publications

Co-morbid psychological dysfunction is associated with a higher risk of asthma exacerbations: a systematic review and meta-analysis

Co-morbid psychological dysfunction is associated with a higher risk of asthma exacerbations: a systematic review and meta-analysis

Associations between stuttering, comorbid conditions and executive function in children: a population-based study

Asthma Over the Age of 65: All's Well That Ends Well

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