Cerebral and autonomic responses to emotional facial expressions in depersonalisation disorder

Lemche, Erwin; Anilkumar, Ananthapadmanabha; Giampietro, Vincent; Brammer, Michael; Surguladze, Simon; Lawrence, Natalia; Gasston, David; Chitnis, Xavier; Williams, Steven; Sierra, Mauricio; Joraschky, Peter; Phillips, Mary L.

doi:10.1192/bjp.bp.107.044263

Cited by 50 publications

(31 citation statements)

References 35 publications

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“…The onset of DPD is often related to stressful life events (1,29), and the acute experience of stress may amplify DPD symptoms (63). As a consequence, patients with DPD show dysregulation in the SAM axis including the autonomic nervous system (7,(64)(65)(66)(67) and the HPA axis (30)(31)(32)(33). The present results suggest higher AA in DPD, but no group differences in cardiovascular sympathetic indices.…”

Section: Discussionmentioning

confidence: 62%

Altered Patterns of Heartbeat-Evoked Potentials in Depersonalization/Derealization Disorder

Schulz

Köster

Beutel

et al. 2015

Psychosomatic Medicine

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Section: Discussionmentioning

confidence: 62%

Altered Patterns of Heartbeat-Evoked Potentials in Depersonalization/Derealization Disorder

Schulz

Köster

Beutel

et al. 2015

Psychosomatic Medicine

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“…Using the above mentioned keywords, forty one studies were listed, out of which thirteen did not fulfil the inclusion criteria: eleven did not measure alexithymia or did not provide information about how alexithymia was associated with performance and/or brain activity [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], and two used the Schalling-Sifnéos Personality Scale to measure alexithymia [48], [49], the validity of which has been questioned [20]. Finally, four studies measured behaviours other than the decoding of EFEs [50], [51], [52], [53].…”

Section: Resultsmentioning

confidence: 99%

Alexithymia and the Processing of Emotional Facial Expressions (EFEs): Systematic Review, Unanswered Questions and Further Perspectives

et al. 2012

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Alexithymia is characterized by difficulties in identifying, differentiating and describing feelings. A high prevalence of alexithymia has often been observed in clinical disorders characterized by low social functioning. This review aims to assess the association between alexithymia and the ability to decode emotional facial expressions (EFEs) within clinical and healthy populations. More precisely, this review has four main objectives: (1) to assess if alexithymia is a better predictor of the ability to decode EFEs than the diagnosis of clinical disorder; (2) to assess the influence of comorbid factors (depression and anxiety disorder) on the ability to decode EFE; (3) to investigate if deficits in decoding EFEs are specific to some levels of processing or task types; (4) to investigate if the deficits are specific to particular EFEs. Twenty four studies (behavioural and neuroimaging) were identified through a computerized literature search of Psycinfo, PubMed, and Web of Science databases from 1990 to 2010. Data on methodology, clinical characteristics, and possible confounds were analyzed. The review revealed that: (1) alexithymia is associated with deficits in labelling EFEs among clinical disorders, (2) the level of depression and anxiety partially account for the decoding deficits, (3) alexithymia is associated with reduced perceptual abilities, and is likely to be associated with impaired semantic representations of emotional concepts, and (4) alexithymia is associated with neither specific EFEs nor a specific valence. These studies are discussed with respect to processes involved in the recognition of EFEs. Future directions for research on emotion perception are also discussed.

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“…Under the assumption that the subtraction map reflects pure emotion-induced cerebral activation at higher intensity levels, 100%–50% aggregate images were computed, after removing neutral facial expression activation. These aggregate images, as previously described26, were used as the basis for correlation analysis with SOMS-2 scales.…”

Section: Methodsmentioning

confidence: 99%

Somatization Severity Associated with Postero-Medial Complex Structures

Lemche

Giampietro

Brammer

et al. 2013

Sci Rep

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Somatisation is a frequent problem in various psychiatric disorders, yet the cerebral mechanisms of somatisation remain unexamined. To test if somatisation is susceptible to emotional states, we investigated relationships between somatisation severity, neural effective connectivity, and autonomic responses to emotional facial expressions. Volunteering participants (N = 20) were presented with facial expressions of happy and sad emotion at three intensity levels (0%–50%–100%) in a fast implicit ER-fMRI design with concurrent derivation of skin conductance levels (SCL). Self-reported somatisation severity as assessed with Rief's SOMS-2 index was correlated with neural response controlling for other clinical traits to ascertain brain bases of somatisation. Regression analyses estimated effective connectivity of main clusters so determined with peripheral autonomic responses. Regions in which magnitude of activity correlated with somatisation severity consisted in both happy and sad conditions of the anterior ventral precuneus (BA7), along with posterior cingulate gyrus (PCC, BA23, sad condition) and anteromedial thalamus (happy condition).

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Cerebral and autonomic responses to emotional facial expressions in depersonalisation disorder

Abstract: The results suggest that fMRI signal decreases are possible correlates of emotion suppression in depersonalisation disorder.

Cited by 50 publications

References 35 publications

Altered Patterns of Heartbeat-Evoked Potentials in Depersonalization/Derealization Disorder

Altered Patterns of Heartbeat-Evoked Potentials in Depersonalization/Derealization Disorder

Alexithymia and the Processing of Emotional Facial Expressions (EFEs): Systematic Review, Unanswered Questions and Further Perspectives

Somatization Severity Associated with Postero-Medial Complex Structures

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