Cerebral Aneurysm and Interleukin-6: a Key Player in Aneurysm Generation and Rupture or Just One of the Multiple Factors?

Monsour, Molly; Croci, Davide Marco; Grüter, Basil E.; Taussky, Philipp; Marbacher, Serge; Agazzi, Siviero

doi:10.1007/s12975-022-01079-4

Cited by 9 publications

(9 citation statements)

References 94 publications

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“…Elevated IL-6 levels in the CSF and blood were correlated to subarachnoid hemorrhage severity and to intracranial aneurysm rupture (23–25). Some researchers speculated that the inhibition of inflammation and IL-6 may constitute a new therapeutic strategy for the prevention of intracranial aneurysm formation and rupture (22). In our patients, the immunosuppressive therapy started for the PCNSV could have conceivably prevented the rupture of aneurysms and the formation of new aneurysms, but smaller patient numbers prevent any definitive conclusions.…”

Section: Discussionmentioning

confidence: 99%

“…All patients were treated with high dose prednisone and most of them also received additional immunodepressive therapy, particularly cyclophosphamide. In recent years different preclinical and clinical studies have established the important role of inflammation, particularly of interleukin-6 (IL-6), in potentiating intracranial aneurysm formation and rupture (22). Elevated IL-6 levels in the CSF and blood were correlated to subarachnoid hemorrhage severity and to intracranial aneurysm rupture (23)(24)(25).…”

Section: Discussionmentioning

confidence: 99%

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Primary Central Nervous System Vasculitis With Intracranial Aneurysm

Salvarani,

Brown,

Christianson

et al. 2024

Preprint

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Background. Unruptured intracranial aneurysms (UIAs) are rarely reported in primary central nervous system vasculitis (PCNSV). In this study we described the clinical findings, response to therapy, and outcomes of UIA in a large cohort of PCNSV patients. Methods. We retrospectively studied 216 consecutive patients with PCNSV, selected by predetermined diagnostic criteria, who were seen during a 40-year period. UIAs were identified on cerebral angiography. The clinical, laboratory, radiologic and pathologic findings, management, and outcomes of patients with UIA were described and compared with those without UIA. Results. 12/216 (5.5%) PCNSV patients had at least one UIA. In the only positive patient biopsy showed necrotizing vasculitis. Eleven patients had evidence of UIA on angiogram at diagnosis. One patient developed an aneurysm during the follow-up associated with a worsening of vasculitic radiological findings. The most common presenting symptom for PCNSV in the setting of UIA was headache (67%), followed by persistent neurologic deficit or stroke (50%). Most patients with UIA presented with multiple cerebral infarcts on MRI (67%), one patient had subarachnoid hemorrhage, and one left parieto-occipital intracerebral hematoma, both unrelated to the aneurysm. Black blood imaging was performed in 4 patients and 2 showed segmental circumferential mural enhancement involving multiple vessels. Two patients had 2 UIAs, while the other 10 had 1. The most frequent UIA location was internal carotid artery (50%), followed by anterior cerebral artery (21%). Ten of the UIAs were < 5 mm in diameter, and 3 were 5-7 mm in diameter; the size was not available for one. All UIAs were unchanged in size and configuration during follow-up and no new aneurysms were detected. Compared to the 204 patients with PCNSV without a UIA, no significant clinical differences were observed, except for a reduced disability at last follow-up (p = 0.038). Conclusions. UIAs uncommonly occur in PCNSV.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Primary Central Nervous System Vasculitis With Intracranial Aneurysm

Salvarani,

Brown,

Christianson

et al. 2024

Preprint

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“…When considering the role of IL-6 in inflammation, it is vital to consider its multiple signaling pathways (Figure 2, adapted from Monsour et al 2022 11 ). While some signaling pathways induce detrimental inflammation, others allow for healing.…”

Section: Il-6 Targetingmentioning

confidence: 99%

Interleukin-6 in Spinal Cord Injury: Could Immunomodulation Replace Immunosuppression in the Management of Acute Traumatic Spinal Cord Injuries?

Croci

Shipman

Monsour

et al. 2023

J Neurol Surg A Cent Eur Neurosurg

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Traumatic spinal cord injuries (SCI) result in devastating impairment to an individual’s functional ability. The pathophysiology of SCI is related to primary injury but further propagated by secondary reactions to injury, such as inflammation and oxidation. The inflammatory and oxidative cascades ultimately cause demyelination and Wallerian degeneration. Currently, no treatments are available to treat primary or secondary injury in SCI, but some studies have shown promising results by lessening secondary mechanisms of injury. Interleukins (ILs) have been described as key players in the inflammation cascade after neuronal injury; however, their role and possible inhibition in the context of acute traumatic SCIs have not been widely studied. Here, we review the relationship between SCI and IL-6 concentrations in the CSF and serum of individuals after traumatic SCIs. Furthermore, we explore the dual IL-6 signaling pathways and their relevance for future IL-6 targeted therapies in SCI.

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“…of the liver (26), is involved in the differentiation of lymphocytes and monocytes and targets the B lymphocyte, T lymphocyte, hepatocyte and hemopoietic progenitor cell (27). In addition, IL-6 is pivotal to the dynamic balance of neurons, and the lack of IL-6 can induce a reduction in the activation of glial cells and alterations in cognitive function in traumatic brain injury (28,29). Other, excessive generation of IL-6 in the brain can also induce nerve degenerative changes (30,31).…”

Section: Comparison Of the Sensory And Motor Nerve Conduction Velocit...mentioning

confidence: 99%

Correlation between the peripheral neuropathy and levels of hs-CRP, IL-1β and IL-6 in senile Parkinson’s disease patients

Zhang¹,

Liu²,

Li³

et al. 2023

Cell Mol Biol (Noisy-le-grand)

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Cerebral Aneurysm and Interleukin-6: a Key Player in Aneurysm Generation and Rupture or Just One of the Multiple Factors?

Cited by 9 publications

References 94 publications

Primary Central Nervous System Vasculitis With Intracranial Aneurysm

Primary Central Nervous System Vasculitis With Intracranial Aneurysm

Interleukin-6 in Spinal Cord Injury: Could Immunomodulation Replace Immunosuppression in the Management of Acute Traumatic Spinal Cord Injuries?

Correlation between the peripheral neuropathy and levels of hs-CRP, IL-1β and IL-6 in senile Parkinson’s disease patients

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