Cerebral aneurysm treatment trends in National Inpatient Sample 2007–2016: endovascular therapies favored over surgery

Wang, Alice S; Campos, Jessica K.; Colby, Geoffrey P.; Coon, Alexander L.; Lin, Li-Mei

doi:10.1136/neurintsurg-2019-015702

Cited by 30 publications

(16 citation statements)

References 11 publications

(24 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Over the past decade, there has been much effort made to identify the best treatment for ruptured and unruptured IA, such as clipping or endovascular treatment (EVT), coiling, or stenting. Technological innovations and advancements in the neuroendovascular space shifted the standard for treating IA from open surgical approaches to endovascular therapies ( 24 ). EVT was mentioned in four articles in the top 10 most-cited articles and three co-cited references with the highest citation bursts (ending in 2021).…”

Section: Discussionmentioning

confidence: 99%

The evolution of intracranial aneurysm research from 2012 to 2021: Global productivity and publication trends

Zhang

Weng

2022

Front. Neurol.

View full text Add to dashboard Cite

BackgroundThis study aimed to analyze the global research trends and map the knowledge network of intracranial aneurysm (IA) research in the last 10 years.MethodsPublications related to IA from 2012 to 2021 were retrieved from the Web of Science core collection. Microsoft Excel 2010 and VOSviewer were used to characterize the largest contributors, including authors, journals, institutions, and countries. CiteSpace and VOSviewer were adopted to analyze the trends and knowledge network of IA.ResultsA total of 5,406 publications related to IA from 2012 to 2021 were identified, increasing from 344 in 2012 to 762 in 2021. Siddiqui, AH from the USA contributed the most publications. Papers published in the journal World Neurosurgery ranked first in quantity, while Stroke ranked first for total citations and citations per publication. The top three prolific institutions were Capital Medical University, Mayo Clinic, and the University Department of Neurology Utrecht from 2012 to 2021. Moreover, the USA held the greatest share in the field, and China was almost on par with the USA due to its rapid growth. Specifically, the most frequently covered topics over the recent decade were subarachnoid hemorrhage, endovascular treatment (EVT), clipping, vascular disorders, flow diverter, stent, delayed cerebral ischemia, inflammation, and hemodynamics.ConclusionThe contribution made by different countries, institutions, journals, and authors for IA research over the past decade was demonstrated in the paper. The main topics include the choice of EVT or surgical clipping, particularly the application of flow diverter and associated complications, while themes such as the etiopathogenetic features of IA (e.g., inflammation and hemodynamics) deserve more attention.

show abstract

Section: Discussionmentioning

confidence: 99%

The evolution of intracranial aneurysm research from 2012 to 2021: Global productivity and publication trends

Zhang

Weng

2022

Front. Neurol.

View full text Add to dashboard Cite

show abstract

“…The fibrin-based FD coating did not induce thrombosis angiographically or histologically and had no adverse effects on the rate of re-endothelialization. Known complications after FD treatment such as stent thrombosis and to a lesser extent in-stent stenosis remain limiting factors of this treatment [ 19 ]. The present study investigated these limiting factors that have prevented FDs from being used in broader patient populations or in critical situations such as the treatment of acutely ruptured aneurysms [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Vascular Response on a Novel Fibrin-Based Coated Flow Diverter

Mühl-Benninghaus

Fries

Kießling

et al. 2021

Cardiovasc Intervent Radiol

View full text Add to dashboard Cite

Purpose Due to thromboembolic complications and in-stent-stenosis after flow diverter (FD) treatment, the long-term use of dual antiplatelet treatment (DAPT) is mandatory. The tested nano-coating has been shown to reduce material thrombogenicity and promote endothelial cell proliferation in vitro. We compared the biocompatibility of coated (Derivo Heal) and non-coated (Derivo bare) FDs with DAPT in an animal model. Methods Derivo® bare (n = 10) and Derivo® Heal (n = 10) FD were implanted in the common carotid arteries (CCAs) of New Zealand white rabbits. One additional FD, alternately a Derivo bare (n = 5) or Derivo Heal (n = 5), was implanted in the abdominal aorta (AA) for assessment of the patency of branch arteries. Histopathological examinations were performed after 28 days. Angiography was performed before and after FD implantation and at follow-up. Results Statistical analysis of the included specimens showed complete endothelialization of all FDs with no significant differences in neointima thickness between Derivo® bare and Derivo® Heal (CCA: p = 0.91; AA: p = 0.59). A significantly reduced number of macrophages in the vessel wall of the Derivo Heal was observed for the CCA (p = 0.02), and significantly reduced fibrin and platelet deposition on the surface of the Derivo Heal was observed for the AA. All branch arteries of the stented aorta remained patent. Conclusion In this animal model, the novel fibrin-based coated FD showed a similar blood and tissue compatibility as the non-coated FD.

show abstract

“…The past few decades have seen a gradual shift from open surgery to endovascular therapies for the treatment of both ruptured and unruptured aneurysms in the USA. 22 Although coils are the archetypical device for endovascular aneurysm treatment and provide a safe and effective therapy for many aneurysms, wide-necked and large or giant aneurysms are still a major challenge. In addition, Fujiwara and Kallmes 23 found that coil embolization led to occasional coil compaction in one of 17 cases (6%) and Dai et al 24 found this to occur in three of 18 cases (17%), both using the same animal model.…”

Section: Discussionmentioning

confidence: 99%

Treatment of experimental aneurysms with a GPX embolic agent prototype: preliminary angiographic and histological results

Fries

Tomori

Schulz‐Schaeffer

et al. 2021

J NeuroIntervent Surg

View full text Add to dashboard Cite

BackgroundRecently, liquid embolic agents have emerged for the endovascular treatment of cerebral aneurysms. Here we describe the in vivo performance of a novel liquid embolization agent (GPX Embolic Device).MethodsElastase-induced aneurysms were embolized with a GPX prototype under balloon assistance. Digital subtraction angiography was performed pre-deployment and immediately after, and at 5, 10, and 30 min post-deployment in 10 rabbits and at 1 month in 8 rabbits. The early post-deployment intra-aneurysmal flow was graded as unchanged, moderately diminished, or completely absent. At 1 month the status of aneurysm occlusion was evaluated. Adhesion to catheter material and migration of GPX was assessed.ResultsThe mean aneurysm neck diameter, width, and height were 3.6±1.0 mm, 3.0±0.8 mm, and 7.4±1.4 mm, respectively. The mean dome-to-neck ratio was 0.9±0.2. Complete stagnation of intra-aneurysmal flow was observed in 9 of 10 aneurysms (90%) within 30 min of device deployment. One aneurysm showed moderately diminished intra-aneurysmal flow at 30 min. At 1 month, 8 aneurysms were completely occluded. There was no evidence of GPX adhesion to the catheter material. Histologically, a leukocyte and foreign body reaction to GPX was detectable 28 days after embolization.ConclusionsThis is the first preclinical study reporting the performance of a protype version of the GPX Embolic Device in a wide-neck aneurysm model. GPX showed promising results by achieving and maintaining high rates of complete angiographic occlusion, but may induce an inflammatory reaction.

show abstract

Cerebral aneurysm treatment trends in National Inpatient Sample 2007–2016: endovascular therapies favored over surgery

Cited by 30 publications

References 11 publications

The evolution of intracranial aneurysm research from 2012 to 2021: Global productivity and publication trends

The evolution of intracranial aneurysm research from 2012 to 2021: Global productivity and publication trends

Vascular Response on a Novel Fibrin-Based Coated Flow Diverter

Treatment of experimental aneurysms with a GPX embolic agent prototype: preliminary angiographic and histological results

Contact Info

Product

Resources

About