Cerebral angiographic findings in thromboangiitis obliterans

No, Young Joo; Lee, Eun M.; Lee, Deok H.; Kim, Jong Seung

doi:10.1007/s00234-005-1445-x

Cited by 29 publications

(22 citation statements)

References 11 publications

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“…Postmortem histological examinations have demonstrated inflammation of the small- and medium-sized arteries of the leptomeninges or even of the meninges or veins [34]. …”

Section: Clinical Featuresmentioning

confidence: 99%

Thromboangiitis Obliterans (Buerger’s Disease)—Current Practices

Vijayakumar

Tiwari

Prabhuswamy

2013

International Journal of Inflammation

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Thromboangiitis obliterans (TAO) is a nonatherosclerotic, segmental inflammatory disease that most commonly affects the small and medium-sized arteries and veins in the upper and lower extremities. Cigarette smoking has been implicated as the main etiology of the disease. In eastern parts of the world TAO forms 40–60% of peripheral vascular diseases. Clinical features and angiographic finding are the basis of early diagnosis of TAO. Abstinence from smoking is the only definitive treatment to prevent disease progression. Medical management in form of aspirin, pentoxyfylline, cilostazol, and verapamil increase pain-free walking distance in intermittent claudication, but long term usage fails to prevent disease progression in patients who continue to smoke. Surgical treatment in form of revascularization, lumbar sympathectomy, omentopexy, and Ilizarov techniques help reduce pain and promote healing of trophic changes. Newer treatment modalities like spinal cord stimulation, prostacyclin, bosentan, VEGF, and stem cell therapy have shown promising results. Latest treatment options include peripheral mononuclear stem cell, and adipose tissue derived mononuclear stem cells have been shown to be effective in preventing disease progression, decrease major amputation rates, and improving quality of life.

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“…Postmortem histological examinations have demonstrated inflammation of the small- and medium-sized arteries of the leptomeninges or even of the meninges or veins [34]. …”

Section: Clinical Featuresmentioning

confidence: 99%

Thromboangiitis Obliterans (Buerger’s Disease)—Current Practices

Vijayakumar

Tiwari

Prabhuswamy

2013

International Journal of Inflammation

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“…Preservation of the internal elastic lamina distinguishes it from true necrotizing forms of arteritis 24 . Very few cases have shown evidence of cerebral involvement, the reported incidence varying between 0.5-18% 25,26 . In our case exam-extracranial segment of the internal carotid artery, through the adventitial vasa vasorum towards the distal arterial territory after longlasting occlusions 32,33 .…”

Section: Discussionmentioning

confidence: 99%

Angiogenesis in Steno-Occlusive Vasculopathies as a Common Pathway for Intracranial Haemorrhage

et al. 2014

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Vasculopathies, including vasculitis of the central nervous system, can lead to stenosed, cicatrized vessels and the development of arterio-arteriolar collateral vessels. Bleeding due to these vascular changes, although rare, does occur. We describe six patients (all female, age range, 21–52 years; mean age, 42 years) with steno-occlusive lesions of intracranial vessels who presented with an acute intracranial haemorrhage. All had arterial steno-occlusive changes in conjunction with extensive leptomeningeal and arterio-arteriolar collaterals. Within the collaterals, focal dilatations could be identified, which were in close spatial relationship with the intracranial haemorrhage. Cause of bleeding was depicted on CT angiography in four out of six patients. One patient presented in childhood with acute stroke, one patient was diagnosed with Buerger's disease and one with sickle cell disease; the other three patients had no relevant history and the exact cause remained unclear. Outcome was favourable in all patients. Despite focal vascular weaknesses, no recurrent haemorrhage was seen during follow-up, supporting, at least in this small patient group, a conservative wait-and-see policy.

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“…However, the aortoiliac region is sporadi- cally affected and involvement of the mesenteric artery, cerebral artery, coronary artery and renal artery during the course of the TAO has been described in the literature (26)(27)(28)(29)(30).…”

Section: Clinical Featuresmentioning

confidence: 99%

Thromoboagiitis Obliterans (TAO)

Park

Kim

2010

Int J Stem Cells

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Thromboangiitis obliterans (TAO) is nonatherosclerotic inflammatory disease of the peripheral blood vessels, and TAO affects the small and medium sized vessels of the extremities. TAO is mainly seen in young males who smoke, and smoking is strongly associated with the disease course and progression. The diagnosis is made on the basis of the history, the physical examination and the clinical diagnostic criteria. As the bedrock for treating patients with TAO, absolute abstinence from tobacco is most important factor, and patients with TAO are usually managed conservatively. Surgical bypass or endovascular therapy is usually not possible for patients with TAO because of the diffuse segmental involvement and the distal nature of the disease. Therefore, stem cell therapy is considered to be a novel therapeutic modality for treating patients with TAO and who are not eligible for conventional revascularization therapies. In this paper, I have summarized the recent knowledge about TAO and I have reviewed the recent studies that have focused on the treatment of TAO.

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Cerebral angiographic findings in thromboangiitis obliterans

Cited by 29 publications

References 11 publications

Thromboangiitis Obliterans (Buerger’s Disease)—Current Practices

Thromboangiitis Obliterans (Buerger’s Disease)—Current Practices

Angiogenesis in Steno-Occlusive Vasculopathies as a Common Pathway for Intracranial Haemorrhage

Thromoboagiitis Obliterans (TAO)

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