Cerebral biopsy and assessment of brain damage in hydrocephalus.

Weller, Roy O.; Williams, B. N.

doi:10.1136/adc.50.10.763

Cited by 36 publications

(16 citation statements)

References 7 publications

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“…Axonal degeneration in the white matter was seen in needle biopsies of the cerebral mantle of children (ages 14 d to 3 y) with acute hydrocephalus, although progressive gliosis was seen in more chronic hydrocephalus, together with signs of cerebral atrophy (65).…”

Section: Axonopathy: Pvl-hydrocephalus Analogymentioning

confidence: 99%

Is Periventricular Leukomalacia an Axonopathy as Well as an Oligopathy?

2001

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Section: Axonopathy: Pvl-hydrocephalus Analogymentioning

confidence: 99%

Is Periventricular Leukomalacia an Axonopathy as Well as an Oligopathy?

2001

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“…Human hydrocephalic patients commonly show CC damage, including astrogliosis with axonal degeneration (49,50), which is modeled in the Wrp KO mice. Currently, the astrogliosis is usually understood as a reactive astrocytosis induced by pressure-mediated mechanical damages in subventricular areas.…”

Section: Risk Of Hydrocephalus During the Early Postnatal Period-mentioning

confidence: 99%

Disruption of Wave-associated Rac GTPase-activating Protein (Wrp) Leads to Abnormal Adult Neural Progenitor Migration Associated with Hydrocephalus

Kim

Carlson

Heindel

et al. 2012

Journal of Biological Chemistry

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Background:Obstructive hydrocephalus results from blockage of the cerebral aqueduct, a poorly understood process. Results: Deletion of Wrp leads to mis-migration of postnatal neural progenitors, tissue disruption, and blockage of the cerebral aqueduct. Conclusion: Wrp is critical for normal neural progenitor migration out of the subventricular zone. Significance: Obstructive hydrocephalus may arise as a result of abnormal neural progenitor properties.

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“…The space can represent a ventricle, a cistern, the subarachnoid space or the entire craniospinal contents. A pulsating [43][44][45][46][47] We propose that a successful model of communicating hydrocephalus should provide satisfactory explanations for the clinical and experimental characteristics of the disease given in this table. The pulsation model of communicating hydrocephalus is consistent with these observations.…”

Section: Analog Csf Spacementioning

confidence: 99%

“…In communicating hydrocephalus, ventricular expansion occurs primarily at the expense of the white matter; the gray matter is less attenuated [43][44][45][46][47].…”

Section: Selective Compression Of White Matter and Sparing Of Gray Mamentioning

confidence: 99%

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A Model of Pulsations in Communicating Hydrocephalus

Egnor¹,

Zheng

Rosiello³

et al. 2002

Pediatr Neurosurg

177

115

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The traditional theory of communicating hydrocephalus has implicated the bulk flow component of CSF motion; that is, hydrocephalus is generally understood as an imbalance between CSF formation and absorption. The theory that the cause of communicating hydrocephalus is malabsorption of CSF at the arachnoid villi is not substantiated by experimental evidence or by physical reasoning. Flow-sensitive MRI has shown that nearly all CSF motion is pulsatile, and there is substantial evidence that hyperdynamic choroid plexus pulsations are necessary and sufficient for ventricular dilation in communicating hydrocephalus. We have developed a model of intracranial pulsations based on the analogy between the pulsatile motion of electrons in an electrical circuit and the pulsatile motion of blood and CSF in the cranium. Increased impedance to the flow of CSF pulsations in the subarachnoid space redistributes the flow of pulsations into the ventricular CSF and into the capillary and venous circulation. The salient features of communicating hydrocephalus, such as ventricular dilation, intracranial pressure waves, narrowing of the CSF-venous pressure gradient, diminished cerebral blood flow, elevated resistive index and malabsorption of CSF, emerge naturally from the model. We propose that communicating hydrocephalus is the result of a redistribution of CSF pulsations in the cranium.

show abstract

Cerebral biopsy and assessment of brain damage in hydrocephalus.

Cited by 36 publications

References 7 publications

Is Periventricular Leukomalacia an Axonopathy as Well as an Oligopathy?

Is Periventricular Leukomalacia an Axonopathy as Well as an Oligopathy?

Disruption of Wave-associated Rac GTPase-activating Protein (Wrp) Leads to Abnormal Adult Neural Progenitor Migration Associated with Hydrocephalus

A Model of Pulsations in Communicating Hydrocephalus

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