Cerebral Blood Flow in Depression

Mathew, RoyJ; Meyer, J; Semchuk, KarenM; Francis, D. M.; Mortel, Karl F.; Claghorn, JamesL

doi:10.1016/s0140-6736(80)91769-9

Cited by 44 publications

(23 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…SPECT has been used in cases of epilepsy, head injuries, cerebral palsy, dementias, drug use, depression, schizophrenia, obsessive-compulsive disorders, and eating disorders [Ryding et al, 1988;Shen et al 1990;AbdelDayem et al, 1987;Denays, 1990;Johnson et al, 1993;Costa et al, 1988;Gemmell et al 1987;Holman et al, 1991;Tumeh et al, 1990;Mathew et al, 1980;Ariel et al, 1983;Berman et al, 1987;Stephenson, 1990]. SPECT has been found to be more sensitive than TCT in diagnostic work with human immunodeficiency virus (HIV) encephalopathy [Masdeu et al, 1991;LaFrance et al, 1988] and acute head lesions [Abdel-Dayem et al, 1987].…”

Section: Introductionmentioning

confidence: 99%

Comparison of single photon emission computed tomography findings in cases of healthy adults and solvent-exposed adults

et al. 1997

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Comparison of single photon emission computed tomography findings in cases of healthy adults and solvent-exposed adults

et al. 1997

View full text Add to dashboard Cite

“…Earlier studies examining cerebral blood flow in younger depressives have been conflicting, with studies showing either a decrease or no change in blood flow in the depressed group when compared to age-matched controls (35,36 PET studies in younger subjects with major depressive disorder revealed that in bipolar depressives, there was a global decline in CMRglc, whereas subjects with unipolar depression showed a relative decline in rCMRglc in the caudate nucleus (38). The same group of investigators additionally reported that a decrease in normalized rCMRglc in the anterolateral prefrontal cortex was found in three distinct types of depressive illness, thereby suggesting that there may be a common biologic pathway that mediates depressive illness across heterogenous clinical states (39).…”

Section: Resultsmentioning

confidence: 99%

Regional cerebral glucose metabolism in late-life depression and Alzheimer disease: a preliminary positron emission tomography study.

Kumar

Newberg

Alavi

et al. 1993

Proc. Natl. Acad. Sci. U.S.A.

115

View full text Add to dashboard Cite

Eight subjects with late-life depression, eight subjects with probable Alzheimer disease, and eight healthy age-matched controls were studied using 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography in the resting state with their eyes open and ears unoccduded. The depressed subjects showed widespread reductions in the regional cerebral metabolic rate for glucose in most major neocortical, subcortical, and paralimbic regions that were signiScantly different from control values (P < 0.01). The metabolic decrements in the depressed group were comparable in magnitude to those seen in the Alzheimer dLwase group. These data demonstrate widespread nonfocal decline in glucose metabolism in late-life depression that is comparable to the hypometabolism seen in Alzheimer disease. These findings have pathophysiological impLications in major depressive disorder in the elderly.Depressive illness is one of the most common mental disorders in the elderly (1, 2). It typically presents as a pervasive disturbance of mood associated with neurovegetative and cognitive signs and symptoms such as disturbance of sleep and appetite, crying spells, fatigue, anhedonia, and loss of attention, concentration, and memory (1, 2). The prevalence of major depressive illness-the most severe form of the disorder-is estimated to be -1% in studies of noninstitutionalized elderly subjects (3). The prevalence of dysthymic disorder and depressive symptoms-less severe but clinically significant forms ofdepression in the same population-is 2-3 and 10-15%, respectively (3). Depression in the elderly is often associated with functional and economic loss, physical illness, institutionalization, and a high rate of suicide (1,2). Despite these staggering consequences, late-life depression remains one of the most underdiagnosed and undertreated conditions in the elderly (1, 2).While the structural basis of late-life depression has been investigated using computerized tomography and magnetic resonance imaging (4-9), there have been very few studies aimed at elucidating the physiologic basis of late-life depression (10, 11). Cerebral blood flow has been examined using the xenon-133 inhalation technique and single photon emission computed tomography (SPECT) in a mixed sample of elderly and younger subjects with major depression and in a small group of subjects with late-life depression (10, 11). Global reduction in blood flow, in the major neocortical regions, has been reported to occur in these subjects when compared to healthy age-matched controls (10). However, given the technical limitations of the xenon-133 technique, only cortical blood flow was examined by this method (10). The question of subcortical, paralimbic, and cerebellar physiological activity in subjects with late-life depression remains unanswered (10). Semiquantitative estimates of blood flowThe publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely t...

show abstract

“…2004;61:877-889 T HE FIRST FUNCTIONAL NEUroimaging studies of depression measured resting cerebral blood flow using xenon Xe 133 inhalation during a resting state. 1 Since then, researchers have used single-photon emission tomography and positron emission tomography to correlate abnormalities in resting state activity with clinical symptoms [2][3][4] and to examine trait abnormalities and state changes after a variety of treatments. [5][6][7][8][9][10] More recent studies have examined specific cognitive [11][12][13] and affective [13][14][15][16] processes and, using functional magnetic resonance imaging (fMRI), have combined cognitive activation paradigms with antidepressant treatments.…”

mentioning

confidence: 99%

Attenuation of the Neural Response to Sad Faces in Major Depressionby Antidepressant Treatment

Williams²,

Cleare

et al. 2004

Arch Gen Psychiatry

739

565

View full text Add to dashboard Cite

show abstract

Cerebral Blood Flow in Depression

Cited by 44 publications

References 5 publications

Comparison of single photon emission computed tomography findings in cases of healthy adults and solvent-exposed adults

Comparison of single photon emission computed tomography findings in cases of healthy adults and solvent-exposed adults

Regional cerebral glucose metabolism in late-life depression and Alzheimer disease: a preliminary positron emission tomography study.

Attenuation of the Neural Response to Sad Faces in Major Depressionby Antidepressant Treatment

Contact Info

Product

Resources

About