Cerebral Blood Flow Pattern Changes in Unilateral Sudden Sensorineural Hearing Loss

Chen, Yue; Li, Haimei; Liu, Bing; Gao, Wenwen; Yang, Aocai; Lv, Kuan; Xia, Hui; Zhang, Wenwei; Yu, Hongwei; Liu, Jian; Liu, Xiuxiu; Wang, Yige; Han, Honglei; Ma, Guolin

doi:10.3389/fnins.2022.856710

Cited by 3 publications

(3 citation statements)

References 38 publications

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“…Specifically, CBF maps originating from arterial spin labelling (ASL) signals are used to assess cerebral blood perfusion without the use of contrast agents. 7 Existing studies have shown a downward trend in CBF involving extra-auditory regions 8 and an increase in CBF in visual-related areas, 9 suggesting that hearing-impaired patients have reduced auditory attention and some degree of compensation for other senses. Resting-state functional MRI (rs-fMRI) has been widely used to investigate spontaneous brain activity through the detection of multiple aspects of BOLD signals, including the amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), regional homogeneity (ReHo) and degree centrality (DC).…”

Section: Introductionmentioning

confidence: 99%

Neurovascular coupling dysfunction associated with cognitive impairment in presbycusis

Xing,

Feng,

Yao

et al. 2024

Brain Communications

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The neuropathological mechanism underlying presbycusis remains unclear. This study aimed to illustrate the mechanism of neurovascular coupling associated with cognitive impairment in patients with presbycusis. We assessed the coupling of cerebral blood perfusion with spontaneous neuronal activity by calculating the correlation coefficients between cerebral blood flow and blood oxygen level-dependent-derived quantitative maps (amplitude of low-frequency fluctuation, fractional amplitude of low-frequency fluctuation, regional homogeneity, degree centrality). Four neurovascular coupling metrics (cerebral blood flow-amplitude of low-frequency fluctuation, cerebral blood flow-fractional amplitude of low-frequency fluctuation, cerebral blood flow-regional homogeneity and cerebral blood flow-degree centrality) were compared at the global and regional levels between the presbycusis group and the healthy control group, and the intrinsic association between the altered neurovascular coupling metrics and the neuropsychological scale was further analysed in the presbycusis group. At the global level, neurovascular coupling was significantly lower in the presbycusis group than in the control group and partially related to cognitive level. At the regional level, neurovascular biomarkers were significantly elevated in three brain regions and significantly decreased in one brain region, all of which involved the Papez circuit. Regional neurovascular coupling provides more information than global neurovascular coupling, and neurovascular coupling dysfunction within the Papez circuit has been shown to reveal the causes of poor cognitive and emotional responses in age-related hearing loss patients.

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Section: Introductionmentioning

confidence: 99%

Neurovascular coupling dysfunction associated with cognitive impairment in presbycusis

Xing,

Feng,

Yao

et al. 2024

Brain Communications

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“…Arterial spinal labeling (ASL) is a imaging method with greater reliability over blood oxygen level-dependent functional magnetic resonance imaging (BOLD-fMRI) that can measure the regional cerebral blood flow (CBF) quantitatively ( Tuite, 2017 ). In recent years, CBF is closely related to normal brain function, so it has attracted much attention in the research of brain function, and may provide a large amount of brain physiological information ( Liang et al, 2013 ), particularly in neurological and psychiatric disorders ( Cui et al, 2017a , b ; Yu et al, 2021 ; Chen et al, 2022 ; Hu et al, 2022 ; Wang et al, 2022 ). However, no study has researched the changes of CBF in anxiety of patients with pulmonary nodules.…”

Section: Introductionmentioning

confidence: 99%

Cerebral Perfusion Patterns of Anxiety State in Patients With Pulmonary Nodules: A Study of Cerebral Blood Flow Based on Arterial Spin Labeling

Wang

Liu

et al. 2022

Front. Neurosci.

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Background and PurposeThe proportion of patients with somatic diseases associated with anxiety is increasing each year, and pulmonary nodules have become a non-negligible cause of anxiety, the mechanism of which is unclear. The study focus on the cerebral blood flow (CBF) of anxiety in patients with pulmonary nodules to explore the cerebral perfusion pattern of anxiety associated with pulmonary nodules, blood perfusion status and mode of pulmonary nodule induced anxiety state.Materials and MethodsPatients with unconfirmed pulmonary nodules were evaluated by Hamilton Anxiety Scale (HAMA). The total score > 14 was defined as anxiety group, and the total score ≤ 14 points was defined as non-anxiety group. A total of 38 patients were enrolled, of which 19 patients were the anxiety group and 19 were the non-anxiety group. All subjects underwent arterial spin labeling imaging using a 3.0 T MRI. A two-sample t-test was performed to compare the CBF between the two groups. The CBF was extracted in brain regions with difference, and Spearman correlation was used to analyze the correlation between CBF and HAMA scores; ROC was used to analyze the performance of CBF to distinguish between the anxiety group and the non-anxiety group.ResultsThe CBF in the right insula/Heschl’s cortex of the anxiety group decreased (cluster = 109, peak t = 4.124, and P < 0.001), and the CBF in the right postcentral gyrus increased (cluster = 53, peak t = −3.912, and P < 0.001) in the anxiety group. But there was no correlation between CBF and HAMA score. The ROC analysis of the CBF of the right insula/Heschl’s cortex showed that the AUC was 0.856 (95%CI, 0.729, 0.983; P < 0.001), the optimal cutoff value of the CBF was 50.899, with the sensitivity of 0.895, and specificity of 0.789. The ROC analysis of CBF in the right postcentral gyrus showed that the AUC was 0.845 (95%CI, 0.718, 0.972; P < 0.001), the optimal cutoff value of CBF was 43.595, with the sensitivity of 0.737, and specificity of 0.842.ConclusionThe CBF of the right insula/Heschl’s cortex decreased and the CBF of the right postcentral gyrus increased in patients with pulmonary nodules under anxiety state, and the CBF of the aforementioned brain regions can accurately distinguish the anxiety group from the non-anxiety group.

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“…Although numerous studies were performed to determine the diagnostic and prognostic biomarkers in SSNHL, no reliable indicator was available in practice ( Huo et al, 2022 ; Park et al, 2022 ). Recently, an increasing number of evidence showed that metabolic diseases were independent risk factors for the occurrence of SSNHL, and pathoglycemia and dyslipidemia significantly affected hearing recovery ( Doo et al, 2020 ; Chen et al, 2022a ; Simões et al, 2022 ). Shen et al (2021) reported that glycosylated hemoglobin A1c levels were increased in SSNHL patients and associated with disease severity and audiogram types.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic and predictive values of serum metabolic profiles in sudden sensorineural hearing loss patients

Wang

Gao

Jiang

2022

Front. Mol. Biosci.

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Sudden sensorineural hearing loss (SSNHL) is an otologic emergency, and metabolic disturbance is involved in its pathogenesis. This study recruited 20 SSNHL patients and 20 healthy controls (HCs) and collected their serum samples. Serum metabolites were detected by liquid chromatography-mass spectrometry, and metabolic profiles were analyzed. All patients were followed up for 3 months and categorized into recovery and non-recovery groups. The distinctive metabolites were assessed between two groups, and their predictive values for hearing recovery were evaluated. Analysis results revealed that SSNHL patients exhibited significantly characteristic metabolite signatures compared to HCs. The top 10 differential metabolites were further analyzed, and most of them showed potential diagnostic values based on receiver operator characteristic (ROC) curves. Finally, 14 SSNHL patients were divided into the recovery group, and six patients were included in the non-recovery group. Twelve distinctive metabolites were observed between the two groups, and ROC curves demonstrated that N4-acetylcytidine, p-phenylenediamine, sphingosine, glycero-3-phosphocholine, and nonadecanoic acid presented good predictabilities in the hearing recovery. Multivariate analysis results demonstrated that serum N4-Acetylcytidine, sphingosine and nonadecanoic acid levels were associated with hearing recovery in SSNHL patients. Our results identified that SSNHL patients exhibited distinctive serum metabolomics signatures, and several serum biomarkers were proved to be potential in predicting hearing recovery. The discriminative metabolites might contribute to illustrating the mechanisms of SSNHL and provide possible clues for its treatments.

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Cerebral Blood Flow Pattern Changes in Unilateral Sudden Sensorineural Hearing Loss

Cited by 3 publications

References 38 publications

Neurovascular coupling dysfunction associated with cognitive impairment in presbycusis

Neurovascular coupling dysfunction associated with cognitive impairment in presbycusis

Cerebral Perfusion Patterns of Anxiety State in Patients With Pulmonary Nodules: A Study of Cerebral Blood Flow Based on Arterial Spin Labeling

Diagnostic and predictive values of serum metabolic profiles in sudden sensorineural hearing loss patients

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