Cerebral cavernous malformations and epilepsy

Awad, Issam A.; Jabbour, Pascal

doi:10.3171/foc.2006.21.1.8

Cited by 151 publications

(130 citation statements)

References 72 publications

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“…En nuestro caso, la resección del angioma sin la resección de la gnosis perilesional permitió el control total de las crisis, lo que también es encontrado por otros autores 1,4 .…”

Section: Discussionunclassified

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Angioma cavernoso cerebral gigante en paciente menor de un año: descripción de un caso

2009

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ResumenLos angiomas cavernosos son poco frecuentes en niños, y son menos frecuentes aún los angiomas cavernosos gigantes.Describimos el caso clínico de un niño de 11 meses que consultó por un cuadro de crisis epilépticas de 5 meses de evolución. Los estudios de imagen (IRM) evidenciaron un angioma cavernoso gigante parietal derecho.Se realizó una resección total de la lesión con control de las crisis.Se reporta el caso dado lo excepcional de la lesión descrita en un paciente menor de un año.PALABRAS CLAVE: Angioma cavernoso. Epilepsia secundaria. Cirugía de la epilepsia. Neurocirugía pediátrica.Giant cerebral cavernous malformation in a child less than 1 year old: case report Summary Cerebral cavernous malformations are rarely described in children. Giant cavernous malformations are exceptional in this group of patients.The authors reports a case of an eleven months boy, who begins at the sixth month of life with epilepsy. Medical therapy was advised and imagenological studies were carried out.An IRM was performed, and shows a giant cavernous malformation in the right parietal lobe.Surgery was carried out, with complete resection of the lesion. In the postoperative period and at more than a year of follow up, he was free of crisis.We report the case because of the rarity of a giant cavernous angioma in a patient less than a year old.

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“…En nuestro caso, la resección del angioma sin la resección de la gnosis perilesional permitió el control total de las crisis, lo que también es encontrado por otros autores 1,4 .…”

Section: Discussionunclassified

“…Pueden presentarse bajo múltiples formas clínicas o ser asintomáticos. De aquéllos que son sintomáticos, la mayoría se presentan con crisis 1,4,8 . El diagnóstico de estas lesiones ha aumentado en las últimas dos décadas por la accesibilidad cada vez mayor a estudios de imagen, en particular la Imagen por Resonancia Magnética (IRM).…”

Section: Introductionunclassified

Angioma cavernoso cerebral gigante en paciente menor de un año: descripción de un caso

2009

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“…For those who have suffered previous bleeding, the annual risk increases to 4.3% per patient. 16 In those harboring posterior fossa CMs and those who have experienced a previous hemorrhage it is 6.75 and 7.78 times more likely, respectively, that they will present with neurological sequelae. 39, 45 Cantu, et al, 10 reported that the risk of intracerebral hemorrhage was only 1.22% per patient per year in lobar CMs and 2.33, 2.39, and 2.82% per patient per year for brainstem, cerebellum, and deep hemispheric CMs, respectively.…”

Section: Treatment Optionsmentioning

confidence: 99%

“…36 Nevertheless, there is an unusual description of posterior fossa CMs presenting with seizures. 6 Because of their anatomical proportions, even small lesions located in the brainstem or cranial nerves in the posterior fossa can cause symptoms. 8 The exception is extraaxial lesions arising from the CPA; these can reach a large size and cause symptoms by compressing the cerebellum, brainstem, and cranial nerves.…”

Section: Clinical Presentationmentioning

confidence: 99%

Neurosurgical management of cerebellar cavernous malformations

Oliveira

Rassi-Neto²,

Ferraz³

et al. 2006

FOC

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Object The aim of this study was to analyze cerebellar cavernous malformations (CMs) with respect to epide-miological, clinical, radiological, and therapeutic aspects. Methods Between 1984 and 2004, 100 patients were surgically treated for intracranial CMs at the Division of Neurosurgery of Federal University of São Paulo. The authors reviewed the records of 10 patients whose lesions were located in the cerebellum. There were four male and six female patients (ratio 1:1.5) whose ages ranged from 14 to 45 years (mean age 33 years). Clinical presentation was sudden or acute in all cases, and neuroimaging examinations performed in all patients demonstrated signs of bleeding. The mean size of the malformations was 4.6 cm, and in all but one patient the lesions were totally removed without complications. After a mean follow-up period of 70 months, all patients were considered to be in good or excellent clinical condition. Conclusions Cerebellar CMs should be analyzed separately from other posterior fossa CMs. These lesions can reach large sizes and cause massive hemorrhages, resulting in acute or sudden presentation. Surgery is a safe and effective option that provides a curative treatment when a complete removal is achieved.

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“…The mechanisms of seizures pathogenesis in CCMs are disputed but there is a literature trend toward rendering hemosiderin, from de blood products leaked from the endothelial cells junctional defect, the main cause due to its epileptogenic effect 26,27 . Hemispheric cavernomas are associated with higher tendency of seizures than other mass lesions in the brain parenchyma, with the potential for evolution for refractory epilepsy in 40% of the cases 25 .…”

Section: Familial Cerebral Cavernous Malformations (Fccm)mentioning

confidence: 99%

Neurocysticercosis, familial cerebral cavernomas and intracranial calcifications: differential diagnosis for adequate management

Gasparetto

Alves-Leon

Domingues

et al. 2016

Arq. Neuro-Psiquiatr.

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Neurocysticercosis (NCC) is an endemic disease and important public health problem in some areas of the World and epilepsy is the most common neurological manifestation. Multiple intracranial lesions, commonly calcified, are seen on cranial computed tomography (CT) in the chronic phase of the disease and considered one of the diagnostic criteria of the diagnosis. Magnetic resonance imaging (MRI) is the test that better depicts the different stages of the intracranial cysts but does not show clearly calcified lesions. Cerebral cavernous malformations (CCM), also known as cerebral cavernomas, are frequent vascular malformations of the brain, better demonstrated by MRI and have also epilepsy as the main form of clinical presentation. When occurring in the familial form, cerebral cavernomas typically present with multiple lesions throughout the brain and, very often, with foci of calcifications in the lesions when submitted to the CT imaging. In the countries, and geographic areas, where NCC is established as an endemic health problem and neuroimaging screening is done by CT scan, it will be important to consider the differential diagnosis between the two diseases due to the differences in adequate management.

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Cerebral cavernous malformations and epilepsy

Cited by 151 publications

References 72 publications

Angioma cavernoso cerebral gigante en paciente menor de un año: descripción de un caso

Angioma cavernoso cerebral gigante en paciente menor de un año: descripción de un caso

Neurosurgical management of cerebellar cavernous malformations

Neurocysticercosis, familial cerebral cavernomas and intracranial calcifications: differential diagnosis for adequate management

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