Cerebral Coenurosis in an Infant

Johnstone, Herbert G.; Jones, Ottiwell W.

doi:10.4269/ajtmh.1950.s1-30.431

Cited by 24 publications

(5 citation statements)

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“…Human brain infestation caused by coenurus is a rare phenomenon, mainly reported in Africa. 20 Ing and colleagues 5 reviewed the six cases of human coenurosis reported in North America; 2,3,6,11,19 only three of them were associated with cerebral infection.…”

Section: Discussionmentioning

confidence: 99%

Huge hemispheric intraparenchymal cyst caused byTaenia multicepsin a child

Benifla¹,

Barrelly²,

Shelef³

et al. 2007

Journal of Neurosurgery: Pediatrics

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The authors report an unusual case of a huge intraparenchymal cyst in a 4-year-old girl caused by Taenia multiceps infection. After surgical removal of the cyst, the child recovered completely. Brain infestation by coenurus is a rare disease, mainly reported in Africa, with a few case reports from patients in developed countries. Humans, especially young children, become intermediate hosts by ingesting eggs passed in the excrement of a definitive host, usually carnivores. In such cases, high mortality and morbidity rates have been reported. These rates decreased after the introduction of the modem neuroradiological techniques of computed tomography and magnetic resonance imaging.

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Section: Discussionmentioning

confidence: 99%

Huge hemispheric intraparenchymal cyst caused byTaenia multicepsin a child

Benifla¹,

Barrelly²,

Shelef³

et al. 2007

Journal of Neurosurgery: Pediatrics

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“…Human coenurosis was first described by Brumpt in 1913, and was long considered an extremely rare disease [ 148 ]. However, to date, approximately 100 human cases have been reported around the world, mostly in sheep-farming regions of Africa [ 151 , 153 ], Europe [ 154 – 158 ], Asia [ 159 ], and the Americas [ 148 , 160 – 163 ].…”

Section: Zoonotic Aspectsmentioning

confidence: 99%

Taenia multiceps coenurosis: a review

et al. 2022

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Taenia multiceps is a taeniid cestode that inhabits the small intestines of both wild and domestic carnivores. The larval stage, Coenurus cerebralis, is typically found in the central nervous system (CNS) of a wide range of livestock and, to a lesser extent, in the extra-cerebral tissues of sheep and goats. This review covers all aspects of the life cycle of T. multiceps and its epidemiology, molecular characterization, pathogenesis, diagnosis, therapy, control and zoonotic potential. Coenurosis caused by the larval stage of T. multiceps has a worldwide distribution and is often fatal in intermediate hosts, which can result in substantial economic losses in livestock farming. Molecular characterization using the mitochondrial genes cytochrome c oxidase subunit 1 and nicotinamide adenine dinucleotide dehydrogenase subunit 1 of different T. multiceps populations has revealed significant genetic variation and the presence of three major haplotypes. The disease mostly affects young sheep and is referred to as either acute or chronic coenurosis. Acute coenurosis occurs as a result of oncospheres migrating through the CNS, while chronic coenurosis occurs as a consequence of the coenurus maturing, which causes displacement and pressure atrophy of brain tissue. Non-cerebral coenurosis has been most commonly reported in goats. The best diagnostic method for cerebral coenurosis involves the interpretation of clinical signs with accurate localization of the cyst using diagnostic imaging techniques. A vaccine based on recombinant oncosphere antigens has proved to be an effective tool against T. multiceps infection in sheep. Additionally, use of anthelmintics during the parasite’s migration stages reduces the development of cysts in the sheep brain. Surgery is considered the most effective method for the treatment of cerebral coenurosis in small ruminants, but is often not carried out because of the limited finances of many sheep and goat breeders. However, coenurosis can also be controlled effectively through preventative measures, such as anthelmintic treatment of dogs and the proper disposal of intermediate host carcasses. The parasite is also zoonotic, and cases of coenurosis have been reported in humans with coenuri located in the brain, spinal cord and eyes. Graphical abstract

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“…There are approximately 30 cases of human CNS coenurosis reported in the scientific literature in South Africa, Europe, India, the USA, Brazil, and Israel (Table 27.1) (Brumpt, 1913; Clapham, 1941; Roger, 1942; Cluver quoted by Craig, 1943; Landells, 1949; Johnstone and Jones, 1950; Becker and Jacobson, 1951a,b; Watson and Laurie, 1955; Ranque and Nicoli, 1955; Bertrand et al, 1956; Correa et al, 1962; D’Andrea and Morello, 1964; Hermos et al, 1970; Michal et al, 1977; Schellhas and Norris, 1985; Pau et al, 1987, 1990; Malomo et al, 1990; Sabattani et al, 2004; Benifla et al, 2007). Becker describes at least 14 additional similar cases (Becker and Jacobson, 1951a).…”

Section: Coenurosismentioning

confidence: 99%

“…The presence of inverted cysts, budding or linear arrangement of daughter scolices provides definitive diagnosis of coenurosis. As explained above, discrimination between species is not possible due to the large overlap in number and size of hooklets (Johnstone and Jones, 1950). Clinically, T. multiceps coenurosis presents more often as a unilocular infection while T. serialis is more commonly multilocular.…”

Section: Coenurosismentioning

confidence: 99%