Cerebral Cortex

Cechetto, David F.; Topolovec, Jane C.

doi:10.1016/b0-12-227210-2/00087-x

Cited by 4 publications

(2 citation statements)

References 2 publications

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“…The survival relevant reactivity moreover requires rapid withdrawal behavior (Rolls, 1999, 2000b), which are potentially mediated by prefrontal, inferior parietal and pallidal regions. In particular prefrontal regions (e.g., superior and medial frontal gyrus) exhibit dense connections with parietal, temporal, and occipital regions (Cechetto and Topolovec, 2002) and play a key role in both, emotional awareness and executive control, including attention and initiation of appropriate responses (LeDoux, 2014; LeDoux and Pine, 2016; Rozzi and Fogassi, 2017) while the inferior parietal lobule is an important locus for motor planning (Buxbaum and Randerath, 2018) and receives input from both, visual as well as somatosensory regions thus being optimal positioned to integrate these modalities (Andersen, 2011). The globus pallidus finally has been implicated in implementing rapid motor reactions in response to emotional stimuli (Sambataro et al, 2006) and via connections with the amygdala regulates responses to (unconditioned) threat stimuli (Giovanniello et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Common and distinct neurofunctional representations of core and social disgust in the brain: Coordinate-based and network meta-analyses

Gan

Zhou

et al. 2021

Preprint

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Disgust represents a multifaceted defensive-avoidance response. On the behavioral level, the response includes withdrawal and a disgust-specific facial expression. While both serve the avoidance of pathogens the latter additionally transmits social-communicative information. Given that common and distinct brain representation of the primary defensive-avoidance response (core disgust) and encoding of the social-communicative signal (social disgust) remain debated we employed neuroimaging meta-analyses to (1) determine brain systems generally engaged in disgust processing, and (2) segregate common and distinct brain systems for core and social disgust. Disgust processing, in general, engaged a bilateral network encompassing the insula, amygdala, occipital and prefrontal regions. Core disgust evoked stronger reactivity in left-lateralized threat detection and defensive response network including amygdala, occipital and frontal regions while social disgust engaged a right-lateralized superior temporal-frontal network engaged in social cognition. Anterior insula, inferior frontal and fusiform regions were commonly engaged during core and social disgust suggesting a common neural basis. We demonstrate a common and separable neural basis of primary disgust responses and encoding of associated social-communicative signals.

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Section: Discussionmentioning

confidence: 99%

Common and distinct neurofunctional representations of core and social disgust in the brain: Coordinate-based and network meta-analyses

Gan

Zhou

et al. 2021

Preprint

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“…This doubling is required to represent the competition between cortical columns in PFC, each corresponds to one of the two decisions. Moreover, the auditory cortex (A1) is organized in terms of columns, similarly to the other sensory cortices [10]. The tonotopic organization of A1 allows for pitch discrimination of the auditory stimuli.…”

Section: Tvbmentioning

confidence: 99%

A whole-brain model of auditory discrimination

Turan,

Baspinar,

Destexhe

2023

Preprint

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Whole-brain simulations have been proposed previously to simulate global properties such as brain states or functional connectivity. Here, our aim is to build a whole-brain model to simulate a paradigm involving multiple brain areas, for instance auditory discrimination, using a paradigm designed for the macaque cortex. We are interested in the neuronal dynamics at the whole-brain scale. We perform our simulations by employing The Virtual Brain (TVB) simulation environment. TVB is a computational framework which is based on the nodes modeling the neuronal populations in the brain, a connectivity which provides the neuronal connections and neuronal pipelines which determines the pathway of the information flow over the brain. We use Adaptive Exponential (AdEx) neuronal population models to describe each node. For the connectivity, we use openly accessible CoCoMac connectivity dataset, which is a matrix containing the connection weights between the nodes. We focus on a cognitive task that mainly involves the prefrontal cortex (PFC). In the auditory discrimination task, our pipeline starts from the primary auditory cortex stimulated by the auditory signals, it is then modulated in the PFC so that the stimulus discrimination occurs. Finally, it ends in the primary motor cortex which outputs the neuronal activity determining the motor action. The aim of this study is to demonstrate the use of whole-brain models to investigate simple cognitive paradigms, such as auditory discrimination in the macaque brain.

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