Cerebral Cortex Activation during Experimentally Induced Ventilator Fighting in Normal Humans Receiving Noninvasive Mechanical Ventilation

Abstract

This study indicates that "ventilator fighting" in healthy humans is associated with an activation of higher cerebral areas. Premotor potentials could thus be markers of patient-ventilator asynchrony at the brain level. Both corroboration in patients and the elucidation of the causative or reactive nature of the association are needed before determining clinical implications.

The Pathophysiology of Respiratory Failure: Control of Breathing, Respiratory Load, and Muscle Capacity

“…Gait is considered as an automatic function, but under certain conditions, gait control becomes dependent on higher specific cortical regions and cognitive function [9]. Recent evidence suggests that the cortical networks [10, 11] engaged in response to inspiratory loading are also activated during complex motor tasks requiring cognitive input, such as gait. It is hypothesized that competition for cortical resources accounts for breathing-cognition interference [12, 13].…”

Electroencephalographic evidence for a respiratory-related cortical activity specific of the preparation of prephonatory breaths

“…This identification was performed in a blinded manner respective to the corresponding study condition. It was complemented by applying an order 1 linear regression to the segment concerned (Raux et al, 2007a(Raux et al, , 2007b. The presence of a pre-inspiratory potential was confirmed when the slope of the linear regression was positive and significantly different from zero, according to an F-test of equality of variances.…”

Pathophysiologie der Ateminsuffizienz: Atmungsregulation, Atemlast und Muskelkapazität

“…Gehen gilt als automatische Funktion, doch je nach Umständen können auch übergeordnete spezifische kortikale Regionen und kognitive Funktionen eingreifen [9]. Aktuelle Studien deuten darauf hin, dass die kortikalen Netzwerke [10,11], die an der Reaktion auf inspiratorische Belastung beteiligt sind, auch bei komplexen motorischen Aufgaben mit kognitivem Input aktiviert werden, zum Beispiel beim Gehen. Einer Hypothese zufolge ist der Wettbewerb um kortikale Ressourcen der Grund für die Atmungs-Kognitions-Interferenz [12,13].…”