Cerebral CT findings in toxemia of pregnancy.

Kirby, Jordan; Jaindl, J J

doi:10.1148/radiology.151.1.6701299

Cited by 46 publications

(4 citation statements)

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“…However, eclamptic fits in patients are asso ciated with cerebral edema and cerebral thrombosis [9]. Vasospasm and vasospasm-induced ischemia are well known to occur in eclampsia [8], In this study, we found clinical convulsions in all 7 pregnant and 2 nonpregnant rabbits after intravenous administration of variable doses (500 pmol/kg) of ET-l. High-voltage spikes, high-voltage fast and high-voltage slow waves in the EEG occurred in all the convulsive rabbits after ET-l administration.…”

Section: Discussionsupporting

confidence: 48%

“…In our pre vious study, we found a HELLP syndrome-like condition in rabbits with endothelin-1 (ET-1) injections [7], Vaso spasm and vasospasm-induced ischemia are well known to occur in eclampsia [8]. Patients with eclamptic fits were found to be associated with cerebral edema [9] and cere bral thrombosis. However, the exact cause of seizures and the disease process still have to be established.…”

Section: Introductionmentioning

confidence: 99%

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Eclampsia-Like Seizures and Electroencephalographic Changes in Pregnant Rabbits with Endothelin-1 Injections

Halim

Kanayama²,

Maradny³

et al. 1995

Gynecol Obstet Invest

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To examine the possible role of endothelin and vasospasm in eclamptic seizures, we studied and analyzed the electroencephalograms (EEG) of endothelin-1 (ET-l)-treated pregnant, nonpregnant and sham control (dextrose-treated) rabbits. After multiple intravenous bolus injections of ET-1 (500 pmol/kg) or 5% dextrose in the rabbits, we recorded EEG directly from the brain cortex and analyzed by Fast Fourier Transform (FFT). Water content was measured in the brain of all groups (n = 7). Repeated seizures occurred in all of the pregnant and 2 of the nonpregnant rabbits by variable doses of ET-1. FFT analysis showed remarkable changes in frequency and power arrays characterized by mild to severe form of dysrhythmia, high-voltage spikes, high-voltage fast and slow waves after ET-1 injections. Water content was increased in brain mass in ET-1-treated rabbits (p = 0.001) suggesting an ET-1-induced edema. Histologically we confirmed that ET-1 caused ischemic changes in brain tissues. However, ET-1 induced more pronounced changes in behavior, EEG, brain edema or ischemia in pregnant than in nonpregnant groups. The injections of exogenous ET-1 into the brain substances were strongly suggested by immunohistochemical study with polyclonal antiendothelin antibody in brain tissue sections. Therefore, we assume that endothelin along with other vasoactive substances causes acute cerebral vasospasm and ischemia inducing EEG changes leading to ultimate clinical convulsions in eclampsia.

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Section: Discussionsupporting

confidence: 48%

Section: Introductionmentioning

confidence: 99%

Eclampsia-Like Seizures and Electroencephalographic Changes in Pregnant Rabbits with Endothelin-1 Injections

Halim

Kanayama²,

Maradny³

et al. 1995

Gynecol Obstet Invest

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“…Eclampsia occurs as a complication of pregnancy with a reported incidence of only 0.05 per cent to 0.2 per cent [6], and the development of transient blindness as a neurologic symptom is an even more rare finding [7]. Cerebral edema has been a consistent finding in the CT reports of patients with eclampsia [8][9][10][11][12]. The presence of vasospasm with poor filling of peripheral vascular territories has also been angiographically proven during the acute episode in two patients [13] providing supportive evidence for the role of vasospasm in the production of neurologic symptoms.…”

Section: Discussionmentioning

confidence: 99%

MR of uncommon congenital and vascular lesions of the intracranial visual pathways

Gammal

Brooks

Harbour³

et al. 1990

Neuroradiology

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The MR findings of two patients with rare congenital abnormalities of the optic pathways are reported and illustrated, including one case of unilateral aplasia of the optic chiasm, tract, and visual radiations and another patient with anophthalmos. In three other patients with unusual vascular causes of visual disturbance, MR was important in early establishment of an accurate diagnosis and had consequent implications for decisions regarding further patient management.

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“…Thrombosed cerebral arterioles cause micro-infarcts and circumferential haemorrhage in the cerebral cortex [106]. Cerebral oedema has been demonstrated by CT scan [107], but was not found at autopsy in women dying with eclampsia [106]. Although generalised convulsions are usual, clinical manifestations depend on the site of ischaemia.…”

Section: Brainmentioning

confidence: 99%

The pathophysiology of pre-eclampsia

Williams

Swiet

1997

Intensive Care Medicine

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Cerebral CT findings in toxemia of pregnancy.

Abstract: Cerebral CT findings in two patients who had eclampsia are presented. Diffuse cerebral edema and basal ganglia involvement, which were previously undescribed to our knowledge, are exhibited.

Cited by 46 publications

References 0 publications

Eclampsia-Like Seizures and Electroencephalographic Changes in Pregnant Rabbits with Endothelin-1 Injections

Eclampsia-Like Seizures and Electroencephalographic Changes in Pregnant Rabbits with Endothelin-1 Injections

MR of uncommon congenital and vascular lesions of the intracranial visual pathways

The pathophysiology of pre-eclampsia

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