Cerebral cysticercosis in pigs studied by computed tomography and necropsy

González, Dante; Rodríguez-Carbajal, Jesús; Aluja, Aline S. de; Flisser, Ana

doi:10.1016/0304-4017(87)90076-8

Cited by 21 publications

(11 citation statements)

References 9 publications

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“…However, all the cysts were found to be viable with mild to moderate inflammation surrounding the lesions, except for one pig, which had increased inflammation, most probably a result of differences in exposure time. Although the present results lack evidence to associate cyst location with the nature and severity of host tissue reaction, the idea of compartmentalization of inflammatory response cannot be disregarded as the lesions evaluated were at an early stage (Gonzalez et al, 1987). Saenz et al, 2008;Sikasunge et al, 2009;Fleury et al, 2010), who suggested the possible occurrence of multiple cysts at different developmental stages in the same individual in both humans and pigs.…”

Section: Discussioncontrasting

confidence: 58%

Distribution and histopathological changes induced by cysts ofTaenia soliumin the brain of pigs from Tanzania

et al. 2014

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Neurocysticercosis (NCC) caused by Taenia solium cysts is a frequent but neglected parasitic disease of the central nervous system (CNS) worldwide. The aim of this study was to describe anatomical locations of cysts in the CNS and the corresponding inflammation. A total of 17 naturally infected pigs were used to evaluate the distribution of cysts and, of these, seven were used to evaluate the corresponding inflammation further, through histopathology. Clinical signs in the pigs included dullness, sluggishness, somnolence, apathy and loss of consciousness. Cysts were distributed in all cerebral lobes, i.e. 39.7% in the frontal lobe, 20.3% in the parietal lobe, 20.0% in the occipital lobe and 19.7% in the temporal lobe, and only 0.4% in the cerebellum. No cysts were found in the spinal cord. Cysts were localized as follows: 47.9% in the dorsal subarachnoid, 46.9% in the parenchyma, 4.4% in the subarachnoid base and 0.9% in the ventricles. The results of the histopathology revealed lesions in an early inflammatory stage, i.e. stage I, in all anatomical locations except for two, which showed more of an inflammatory reaction, stage III, in one pig. It was concluded that clinical signs in pigs were neither pathognomonic nor consistent. These signs, therefore, cannot be used as a reliable indicator of porcine NCC. Furthermore, T. solium cysts were found to be in abundance in all cerebral lobes, and only a few were found in the cerebellum. Regarding the inflammatory response, no significant differences were found in the location and total number of cysts. Thus, further studies are needed to explain the determinants of cyst distribution in the CNS and assess in detail clinical signs associated with porcine NCC.

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Section: Discussioncontrasting

confidence: 58%

Distribution and histopathological changes induced by cysts ofTaenia soliumin the brain of pigs from Tanzania

et al. 2014

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“…The eosinophils as inflammatory cell in some sections were probably due to successive changes of the same lesion and possibly linked to death of the parasite. Differences in the type of inflammatory lesions depend upon survivability of parasite or indirectly to the host immune response (Gonzalez et al, 1987). In the present study, granuloma formation that is characteristic of type III and IV lesions as reported by Alvarez et al, (2002) was not noticed and the possible reason could be the less time available for such lesions to develop in pigs of market age that were in general not more than 1-2 yrs old.…”

Section: Resultsmentioning

confidence: 74%

Neurocysticercosis in free roaming pigs – a slaughterhouse survey

Prakash

Kumar

Rout

et al. 2007

Trop Anim Health Prod

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To investigate the prevalence of neurocysticercosis among free ranging pigs and to study the type of pathomorphological lesions in affected brains, a total of 200 brains were collected from pigs slaughtered at a local abattoir, between August, 2005 to March, 2006. Gross and histopathological examination revealed 3% (6/200) occurrence of neurocysticercosis in pigs. Taenia solium cysticercosis is an under-rated zoonosis and is a leading cause of epilepsy due to neurocysticercosis in human population of India. The prevailing situation warrants immediate implementation of effective control measures for this dreaded disease.

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“…The close similarity between human and swine NCC (11, 12) prompted us to make use of swine as a model for detailed MRI and histopathologic correlation study that may be extrapolated for human NCC. Although computed tomography (CT) and histopathology in cerebral cysticercosis in swine has been studied previously (16), correlation of MRI with histopathology is likely to reveal many other inferences that remain hidden on CT.…”

Section: Discussionmentioning

confidence: 99%

Correlative MR imaging and histopathology in porcine neurocysticercosis

Chawla

Husain

Kumar

et al. 2004

Magnetic Resonance Imaging

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Purpose:To examine whether all the histopathologically seen features of cysticercus cysts excised from brain of swine naturally infected with neurocysticercosis during its evolution are actually visible on magnetic resonance imaging (MRI). Materials and Methods:Five swine naturally infected with cerebral cysticercosis were subjected to fast spin-echo (SE) T2, SE T1, fluid attenuated inversion recovery imaging, T1-weighted magnetization transfer (MT), and postcontrast T1-weighted MT sequences on MRI. These animals were sacrificed after imaging and ex vivo imaging of the intact excised brain using the same imaging protocol was also performed. Grossing of these brains was done similar to the ex vivo imaging planes. Numeral density and external appearance of each cyst and scolex were evaluated on each pulse sequence. Amount of pericystic edema, if present, was also assessed. On histopathology, cellular characteristics, inflammatory response, and the extent of edema, if present, in the brain parenchyma around the cysts were graded. Cysts were categorized into viable, early, and late degenerated on histopathology. The MRI features of each cyst were correlated with their histopathologic findings. Results:Out of 31 cysts, eight were found to be viable, 13 early degenerated, and 10 late degenerated on histopathology. T2-weighted imaging demonstrated all the cysts while T1-weighted imaging showed 97% of the cysts. Scolex was seen in 90.3% and 93.5% of the cysts on T2-and T1-weighted images, respectively. Minimal edema (grade I) and inflammation in degenerating cysts present on histopathology was not visible on MRI. All but one of eight degenerated cysts, which showed enhancement on postcontrast MRI, had edema on imaging as well as on histopathology. Conclusion:T2-weighted MRI demonstrated all the cysts that were visible on histopathology. Non-enhancement of some of the degenerated cysts along with absence of edema on MRI is likely to underestimate the staging of neurocysticercosis evolution, and these early degenerating cysts may be misdiagnosed as in viable stage.

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Cerebral cysticercosis in pigs studied by computed tomography and necropsy

Cited by 21 publications

References 9 publications

Distribution and histopathological changes induced by cysts ofTaenia soliumin the brain of pigs from Tanzania

Distribution and histopathological changes induced by cysts ofTaenia soliumin the brain of pigs from Tanzania

Neurocysticercosis in free roaming pigs – a slaughterhouse survey

Correlative MR imaging and histopathology in porcine neurocysticercosis

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