Cerebral Functional, Metabolic, and Hemodynamic Effects of Etomidate in Dogs

Milde, Leslie Newberg; Milde, James H.; Michenfelder, John D.

doi:10.1097/00000542-198510000-00005

Cited by 118 publications

(34 citation statements)

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“…This is in agreement with other centrally acting anaesthetics, since burst suppression occurs with barbiturates [3 1,321, isoflurane [18,33,34], desflurane [21], etomidate [35] and propofol [23]. With regard to anaesthetic depth, burst suppression does not reliably indicate a deep or adequate anaesthetic state; nor does it prevent reactions to noxious stimuli such as laryngoscopy and intubation [24,37].…”

Section: Discussionsupporting

confidence: 72%

Clonidine: an adjunct in isoflurane N₂O/O₂ relaxant anaesthesia

et al. 1995

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Section: Discussionsupporting

confidence: 72%

Clonidine: an adjunct in isoflurane N₂O/O₂ relaxant anaesthesia

et al. 1995

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“…The different effects of iv anesthetics on oxygen saturation may be due to the different actions on cerebral blood flow and oxygen consumption; both propofol and thiopental maintain flow-metabolism coupling 12 whereas etomidate is associated with a rapid reduction in cerebral blood flow accompanied by a slower reduction in oxygen consumption. 13 Iwasaki et al 14 compared the effects of higher doses of sevoflurane (8%) on cerebral blood volume with 5% sevoflurane and propofol on cerebral volume using BIS and NIRS during induction of anesthesia. Only vital capacity inhalation with 8% sevoflurane produced an increase in cerebral blood volume, suggesting that high concentrations of sevoflurane may be dangerous in patients with elevated intracranial pressure.…”

Section: Discussionmentioning

confidence: 99%

Ľindex bispectral et la saturation en oxygène du sang cérébral régional pendant ľanesthésie au propofol/N2O

Kanemaru

Nishikawa

Goto

2006

Can J Anesth/J Can Anesth

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Purpose:A study was undertaken to compare the influence of midazolam, isoflurane, and aminophylline (which may antagonize anesthetic action) on bispectral index (BIS) and regional cerebral oxygen saturation (rSO 2 ) during propofol/N 2 O anesthesia, and to test the hypothesis that the drug-induced changes in BIS values are accompanied by a change in rSO 2 .Methods: General anesthesia was administered to 36 patients with a continuous infusion of propofol to maintain a BIS value of 40 ± 5. After baseline recordings, patients were randomly assigned to receive either midazolam, isoflurane, or aminophylline. Bispectral index values, rSO 2 using near-infrared spectroscopy, and hemodynamic parameters were recorded for 60 min.Results: Midazolam (0.05 mg·kg -1 ) significantly decreased the BIS from 47.8 ± 5.4 to 35.0 ± 4.5 at five minutes after injection (P < 0.001 vs control) during propofol anesthesia, whereas the rSO 2 was unchanged. Similarly, isoflurane (1.1% end-tidal) decreased the BIS from 42.5 ± 7.5 to 27.8 ± 6.9 (P < 0.001) without affecting rSO 2 . In contrast, aminophylline (3 mg·kg -1 ) was associated with an increase in BIS from 41.6 ± 2.1 to 48.3 ± 9.2 at five minutes after injection (P < 0.05) without affecting rSO 2 .Conclusions: Midazolam or isoflurane-induced decreases in the BIS during propofol anesthesia were not accompanied by a decrease in rSO 2 . Aminophylline significantly increased the BIS score during propofol anesthesia, suggesting that aminophylline can antagonize, at least in part, the sedative actions of propofol. 47,8 ± 5,4 à 35,0 ± 4,5 cinq minutes après l'injection (P < 0,001 vs témoin) pendant l'anesthésie au propofol, tandis que la rSO 2 n'a pas changé. De même,1,1 %) a diminué le BIS de 42,5 ± 7,5 à 27,8 ± 6,9 (P < 0,001) Objectif : Comparer l'influence du midazolam, de l'isoflurane et de l'aminophylline (qui peut contrer l'action anesthésique) sur l'index bispectral (BIS) et

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“…The later result can exist because low concentration of phytoestrogens might not be adequate to fully activate the neuroprotective pathways [19] for prohibiting ICP elevation on days post-TBI. The causes of the ICP increase in TBI could be hypoxia [45], the reduction of cerebral blood flow [46], cerebral edema [47], ischemic injury, hyper-perfusion in the early stages after TBI [48], changes in the expression of aquaporin-4 [49] and vaso-paralysis, and impaired auto-regulation [50]. It seems that our study is the first to evaluate the effect of soy on ICP.…”

Section: Discussionmentioning

confidence: 99%

Can Soy Diet be Protective in Severe and Diffuse Traumatic Brain Injury?

Soltani¹,

Khaksari²

2014

J Neurol Neurophysiol

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Our previous studies have demonstrated that estrogen is protective in traumatic brain injury (TBI). However, concerns about negative consequences of estrogen therapy have led to find other strategies to obtain estrogen's benefits in the brain, including the use of a soy diet. This study was designed to determine whether a soy diet is protective in TBI. The male Albino N-Mary rats received either a soy-free diet (SFD) or soy diet (SD) from weaning to adulthood. The SFD and SD rats were separately divided to two groups of sham and TBI (n= 18 in each group). The diffuse and severe brain injury was induced by Marmarou method. The disruption of Blood brain-barrier (BBB) was evaluated 48 h post-TBI. The intracranial pressure (ICP), the neurologic outcome, and the beam-walk task (WB) were determined before trauma, on trauma day (D0), and first (D1) and second (D2) days post-TBI. Evans blue dye was significantly high in the SFD + TBI group vs. other groups. The ICP was significantly high in the SFD + TBI group in all times evaluated, and in the SD + TBI group on D1 and D2, however lower than that in the former group. The neurologic outcome score was significantly low in the SFD + TBI group vs. the sham groups in all times. Also the traversal time in WB task was significantly high in the SFD + TBI group not the SD + TBI group, vs. the sham groups in all times, however significant difference of distance traveled was shown only on trauma day. The results of this study demonstrate that soy diet can prevent the disruption of BBB, and attenuate the elevation of ICP, and the disturbance of vestibulomotor and neurologic performance in TBI.

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Cerebral Functional, Metabolic, and Hemodynamic Effects of Etomidate in Dogs

Cited by 118 publications

References 0 publications

Clonidine: an adjunct in isoflurane N₂O/O₂ relaxant anaesthesia

Clonidine: an adjunct in isoflurane N₂O/O₂ relaxant anaesthesia

Ľindex bispectral et la saturation en oxygène du sang cérébral régional pendant ľanesthésie au propofol/N2O

Can Soy Diet be Protective in Severe and Diffuse Traumatic Brain Injury?

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Cerebral Functional, Metabolic, and Hemodynamic Effects of Etomidate in Dogs

Cited by 118 publications

References 0 publications

Clonidine: an adjunct in isoflurane N2O/O2 relaxant anaesthesia

Clonidine: an adjunct in isoflurane N2O/O2 relaxant anaesthesia

Ľindex bispectral et la saturation en oxygène du sang cérébral régional pendant ľanesthésie au propofol/N2O

Can Soy Diet be Protective in Severe and Diffuse Traumatic Brain Injury?

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Product

Resources

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Clonidine: an adjunct in isoflurane N₂O/O₂ relaxant anaesthesia

Clonidine: an adjunct in isoflurane N₂O/O₂ relaxant anaesthesia