Cerebral ganglioglioma with anaplastic oligodendroglial component

Abstract

We report an unusual and possibly unique example of cerebral ganglioglioma with an anaplastic oligodendroglial component. The latter was documented on both morphological and immunohistochemical grounds. Immunohistochemically, the anaplastic cells were strongly positive with the monoclonal antibody anti-Leu-7, while they lacked glial fibrillary acid protein, vimentin and neurofilaments.

Anaplastic Ganglioglioma of the Cerebellopontine Angle-Case Report-

“…10,[12][13][14][15]18) Previous cases manifested anaplastic histological features at initial resection. [1][2][3][4]8,9,11,[16][17][18]23,24) In our case, hypercellularity, mitotic figures, and endothelial proliferation were present in the astrocytic component, and thus satisfied the anaplastic criteria. Additionally, the short duration of clinical manifestation suggests de novo tumor anaplasia.…”

“…Malignant variants of ganglioglioma have been reported, [1][2][3][4]6,[8][9][10][11][12][13][14][15][16][17][18]20,21,23,24) but the incidence remains unknown. Two of 63 gangliogliomas were World Health Organization grade III 17) and three anaplastic variants were identified among 61 gangliogliomas.…”

“…21) Table 1 lists 10 cases of anaplastic gangliogliomas for which clinical details were provided. [1][2][3][4][5][7][8][9]18,23) Six patients died of tumor progression within 5 to 26 months after the initial diagnosis. We suggest that such anaplastic tumors exhibit aggressive biological behavior.…”

Evolução maligna de um ganglioglioma: relato de caso

“…Considerado tumor raro, com incidência entre 0,4% a 7,6% em séries puramente pediátricas e, considerando-se toda população, a incidência não ultrapassa de 0,5% a 1,5%, entre todos os tumores do sistema nervoso central [1][2][3][4][5][6][10][11][12][13][14] . Acomete portanto principalmente jovens, pois a literatura mostra que entre 60% a 80% dos casos apresentavam idade inferior a 30 anos no momento do diagnóstico, não existindo preponderância quanto ao sexo [1][2][3] .…”

“…Segundo vários autores, a evolução maligna desta neoplasia provavelmente é determinada pelo componente glial e não neuronal 1,2,[6][7][8][9][10]13,15,20 . Russell e Rubinstein 8 relataram caso de indiferenciação para glioblastoma 23 anos após a remoção cirúrgica de um ganglioglioma, sendo importante ressaltar que este paciente não havia sido submetido a radioterapia.…”