Cerebral glucose metabolism, clinical, neuropsychological, and radiological profile in patients with corticobasal syndrome

Turaga, Surya Prabha; Mridula, Rukmini; Borgohain, Rupam

doi:10.4103/0028-3886.107916

Cited by 14 publications

(14 citation statements)

References 20 publications

(27 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Widespread hypometabolism on fluorodeoxyglucose PET (FDG‐PET) of the frontal, temporal, and parietal lobes, as well as the basal ganglia, have been described in CBS, particularly contralateral to the most affected side (Fig. ) …”

Section: Cbsmentioning

confidence: 99%

Cognition in corticobasal syndrome and progressive supranuclear palsy: A review

2014

View full text Add to dashboard Cite

Corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP) represent challenging neurodegenerative disorders for clinicians and nonclinical scientists alike. Although initially lumped together as "Parkinson's-Plus" syndromes, CBS and PSP are clinically and pathologically distinct from Parkinson's disease. It is now clear that behavioral and cognitive changes are common in both syndromes and affect impact quality of life and carer burden considerably. We briefly review the clinical, pathological, and neuroradiological features of each syndrome, followed by more detailed descriptions of the behavioral and cognitive deficits encountered in CBS and PSP. Clinically and pathologically heterogeneous, CBS is characterized by a wide range of cognitive and behavioral disturbances. impairments in executive function and memory are common, but nonspecific. In contrast, deficits in language and visuospatial abilities appear to be more distinctive features of CBS; the relevance of specific patterns of impairment to the underlying histopathology, or prognosis, remains to be fully elucidated. As in CBS, behavioral and cognitive changes are almost universal in PSP, with a wide range of reported deficits. Apathy is very common, often paradoxically accompanied by impulsivity. Executive dysfunction is prominent, but memory and visuospatial deficits also occur. An emerging field is the study of social cognition, which appears impaired in both syndromes. As therapeutic strategies for neurodegenerative pathologies emerge, more specific diagnostic tools in CBS and PSP will be required. Careful clinicopathological correlation, and the development of biomarkers for specific histopathologies, will be important milestones on the road to effective treatments.

show abstract

Section: Cbsmentioning

confidence: 99%

Cognition in corticobasal syndrome and progressive supranuclear palsy: A review

2014

View full text Add to dashboard Cite

show abstract

“…[14] In addition to areas of cortical hypometabolism seen in movement disorders, there is evidence of basal ganglia hypometabolism as well, in Parkinsonian syndromes like corticobasal syndrome and multisystem atrophy. [1516] The choreiform movements associated with nonketotic hyperglycemia are potentially reversible as rapid detection and early correction of hyperglycemia can lead to complete recovery of these involuntary movements in several cases. Due to the reversible nature of the condition, ischemic injury to the basal ganglia, which may be more likely partial and reversible appears to be the most plausible explanation.…”

Section: Discussionmentioning

confidence: 99%

18F-fluorodeoxyglucose positron emission tomography/computed tomography in a case of non-ketotic hyperglycemia

D’Souza¹,

Sharma²,

Jaimini³

et al. 2014

Indian J Nucl Med

View full text Add to dashboard Cite

Hemichorea and generalized chorea are rare syndromes associated with nonketotic hyperglycemia. This disorder usually afflicts elderly females, and may herald the onset of new onset diabetes, usually type 2. There are conflicting reports of the underlying pathophysiology of this rare entity. Magnetic resonance imaging findings have been described in the past, and are characteristic. There are very few reports of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) findings of this unusual dyskinetic syndrome. This report describes the PET/CT features of this rare disease. Early detection and prompt correction of hyperglycemia may lead to complete or significant amelioration of symptoms.

show abstract

“…Les ratios tau/Ab42, p-tau/Ab42 et le Innotest Amyloid Tau coupure : 0,4 cm À1 ) puis corrigées de l'atténuation par la méthode de Chang (m = 0,12 cm À1 ). Afin d'augmenter la puissance statistique des analyses et puisque les profils lésionnels des SCB sont généralement asymétriques prédominant du côté opposé à l'atteinte clinique [33][34][35]41,49,[56][57][58], les scintigraphies des patients présentant la latéralisation de la symptomatologie minoritaire eurent une rotation de 1808 selon un axe vertical (« flip » droite-gauche) pour des analyses complémentaires. Les flips concernaient 4 patients (1 patient SCB-MA et 3 patients SCB-nonMA) qui présentaient une symptomatologie dominante de l'hémicorps gauche (les 11 autres patients présentaient une symptomatologie dominante de l'hémicorps droit).…”

Section: Critères Nécessairesunclassified

“…Cambridge modified criteria [16] for the diagnosis of CBS. [33][34][35]. Le cervelet et le mésencéphale sont habituellement préservés [33,34].…”

Section: Introductionunclassified

See 1 more Smart Citation

Apport de la scintigraphie de perfusion cérébrale dans l’exploration du syndrome cortico-basal

et al. 2015

View full text Add to dashboard Cite

Cerebral glucose metabolism, clinical, neuropsychological, and radiological profile in patients with corticobasal syndrome

Abstract: 18 FDG PET brain is more sensitive than MRI brain in the early diagnosis of CBS and also correlates well with neuropsychological assessment.

Cited by 14 publications

References 20 publications

Cognition in corticobasal syndrome and progressive supranuclear palsy: A review

Cognition in corticobasal syndrome and progressive supranuclear palsy: A review

18F-fluorodeoxyglucose positron emission tomography/computed tomography in a case of non-ketotic hyperglycemia

Apport de la scintigraphie de perfusion cérébrale dans l’exploration du syndrome cortico-basal

Contact Info

Product

Resources

About