Cerebral glucose metabolism in corticobasal degeneration comparison with progressive supranuclear palsy using statistical mapping analysis

Juh, R; Pae, Chi‐Un; Kim, Tae-Suk; Lee, Chang-Uk; Choe, Bo-Young; Suh, T

doi:10.1016/j.neulet.2005.03.057

Cited by 49 publications

(27 citation statements)

References 16 publications

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“…The detailed PET procedure has been described previously [15]. In brief, FDG-PET images were obtained using a Headtome IV scanner (Shimadzu, Kyoto, Japan).…”

Section: Methodsmentioning

confidence: 99%

“…In this study, we applied an uncorrected threshold of p < 0.001 on the basis of the results obtained in the previous studies, in which the frontal lobes and the midbrain were found as the regions of hypometabolism [15, 16, 17, 18] or decreased gray matter [12, 13] in patients with PSP.…”

Section: Methodsmentioning

confidence: 99%

“…Using voxel-based morphometry (VBM) with MRI [12, 13] and voxel-based positron emission tomography (PET) analysis [14, 15, 16, 17, 18] of PSP cases, reductions in gray matter and metabolic activity have been observed primarily in the frontal lobe and basal midbrain.…”

Section: Introductionmentioning

confidence: 99%

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Brain Alterations and Mini-Mental State Examination in Patients with Progressive Supranuclear Palsy: Voxel-Based Investigations Using 18F-Fluorodeoxyglucose Positron Emission Tomography and Magnetic Resonance Imaging

Takahashi¹,

Ishii²,

Kakigi³

et al. 2011

Dement Geriatr Cogn Disord Extra

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Background/Aims: The aim of this study was to compare differences in morphological and functional changes in brain regions in individual patients with progressive supranuclear palsy (PSP) and correlate their Mini-Mental State Examination (MMSE) score with anatomy and function using magnetic resonance imaging (MRI) and ¹⁸F-fluorodeoxyglucose positron emission tomography (FDG-PET). Methods: Sixteen PSP patients and 20 age-matched healthy volunteers underwent FDG-PET and 3-dimensional MRI. Gray matter, white matter and metabolic activity were compared between patients and normal controls. In addition, possible correlations between the MMSE score and brain function/anatomy were examined. Results: The PSP group had reduced cerebral glucose metabolism, and lower gray and white matter volumes in the frontal lobes and midbrain compared with normal controls. In PSP subjects, the metabolic changes observed in the PET scans were greater than the loss in gray and white matter observed in the MRI scans. The MMSE scores were positively correlated with volume and FDG uptake in the frontal lobe. Conclusion: FDG-PET is a more effective tool in the diagnosis of PSP than MRI. Atrophy and hypometabolism in the frontal lobe are as important as in the basal midbrain for differentiating PSP patients who primarily exhibit cognitive dysfunction from normal controls.

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“…The detailed PET procedure has been described previously [15]. In brief, FDG-PET images were obtained using a Headtome IV scanner (Shimadzu, Kyoto, Japan).…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Brain Alterations and Mini-Mental State Examination in Patients with Progressive Supranuclear Palsy: Voxel-Based Investigations Using 18F-Fluorodeoxyglucose Positron Emission Tomography and Magnetic Resonance Imaging

Takahashi¹,

Ishii²,

Kakigi³

et al. 2011

Dement Geriatr Cogn Disord Extra

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“…This correlates with elevated CSF t-tau and p-tau and reduced metabolism. By comparison, CBS typically has asymmetric hypoperfusion within the parietofrontal cortex and basal ganglia [78,79], although PET findings in pathologically proven CBD are rarely reported. Asymmetric hypometabolism in the contralateral frontoparietal cortex, basal ganglia and cerebellum has been reported [14].…”

Section: Comparison Of Cbs-ad To Cbs-cbdmentioning

confidence: 99%

The corticobasal syndrome–Alzheimer’s disease conundrum

Hassan

Whitwell

Josephs

2011

Expert Review of Neurotherapeutics

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Corticobasal syndrome (CBS), once thought to be pathognomonic for corticobasal degeneration pathology, is increasingly reported with various underlying pathologies. Alzheimer’s disease is one such pathology, also once believed to be unique for its clinical syndrome of dementia of the Alzheimer’s type. CBS is believed to result from topography of asymmetric parietofrontal cortical lesion involvement, rather than lesion subtype. However, this topographical pattern is strikingly different to that typically associated with AD for unclear reasons. This article will focus on CBS with underlying AD pathology (CBS-AD), and will review associated clinical, imaging and demographic factors. Predicting AD pathology is of marked interest as disease-modifying therapies loom on the horizon, with biomarkers and imaging research underway. By reviewing the literature for CBS-AD case reports and series and contrasting them with CBS with underlying corticobasal degeneration pathology cases, the article aims to examine factors that may predict AD pathology. How AD pathology may produce this clinical phenotype, rather than the prototype dementia of the Alzheimer’s type, will also be reviewed.

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“…One limitation of many of these imaging studies is that many are carried out in living participants with CBS without any correlative tissue for defi nitive diagnosis. Juh et al (2005) report asymmetric hypoperfusion in the parietal and frontal cortices as well as in the basal ganglia. Teune et al (2010) similarly performed fl uorodeoxyglucose positron emission tomography (FDG-PET) imaging on CBS patients and found disease-specifi c patterns of relatively decreased metabolic activity specifi cally in the cortical regions contralateral to the affected limb.…”

Section: Corticobasal Degenerationmentioning

confidence: 93%

Neuropsychiatry of corticobasal degeneration and progressive supranuclear palsy

Bruns

Josephs

2013

International Review of Psychiatry

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Corticobasal syndrome (CBS) and progressive supranuclear palsy syndrome (PSPS) are two of the atypical Parkinsonism syndromes, in that patients exhibit rigidity, occasional tremor and postural instability, but do not symptomatically respond to dopamine replacement. CBS and PSPS can often present with complex cognitive difficulties and neuropsychiatric disturbances. Symptoms of depression, apathy, or agitation can be subtle and are often overlooked as reactions to learning a new diagnosis of Parkinsonism. These symptoms may be the earliest presenting evidence of CBS or PSPS, and these syndromes can be misdiagnosed with a primary psychiatric disorder rather than a neurodegenerative condition. Patients may be inappropriately treated with antipsychotic medications that exacerbate the extra-pyramidal motor features of the syndromes. When symptoms are considered to comprise a neurodegenerative syndrome, it may be an inaccurate diagnosis as many features of CBS and PSPS not only overlap with each other, but also with other dementia syndromes. This review discusses similarities and differences between the syndromes of CBS and PSPS in terms of neuropsychiatric features. Improved characterization of the clinical syndromes is necessary to better predict underlying pathology. Improved education about these diseases would help patients, caregivers and clinicians to anticipate symptom progression and avoid premature nursing home placement.

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Cerebral glucose metabolism in corticobasal degeneration comparison with progressive supranuclear palsy using statistical mapping analysis

Cited by 49 publications

References 16 publications

Brain Alterations and Mini-Mental State Examination in Patients with Progressive Supranuclear Palsy: Voxel-Based Investigations Using 18F-Fluorodeoxyglucose Positron Emission Tomography and Magnetic Resonance Imaging

Brain Alterations and Mini-Mental State Examination in Patients with Progressive Supranuclear Palsy: Voxel-Based Investigations Using 18F-Fluorodeoxyglucose Positron Emission Tomography and Magnetic Resonance Imaging

The corticobasal syndrome–Alzheimer’s disease conundrum

Neuropsychiatry of corticobasal degeneration and progressive supranuclear palsy

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