Cerebral Glucose Utilization Measured With High Resolution Positron Emission Tomography in Epileptic Finnish Spitz Dogs and Healthy Dogs

Viitmaa, Ranno; Haaparanta‐Solin, Merja; Snellman, Marjatta; Cizinauskas, Sigitas; Orro, Toomas; Kuusela, Erja; Johansson, Jarkko; Viljanen, Tapio; Jokinen, Tarja S.; Bergamasco, L.; Metsähonkala, Liisa

doi:10.1111/vru.12147

Cited by 16 publications

(19 citation statements)

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“…Positron emission tomography has been used increasingly in veterinary medicine over the past few years, but applications have been limited to small animals, primarily dogs and cats . To date, the use of PET has never been reported in the horse .…”

Section: Introductionmentioning

confidence: 99%

Positron Emission Tomography of the Equine Distal Limb: Exploratory Study

Spriet

Espinosa

Kyme

et al. 2016

Vet Radiology Ultrasound

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Positron emission tomography (PET) is a highly sensitive, noninvasive imaging technique for quantifying biological functions of tissues. However, at the time of this study, PET imaging applications had not been reported in the horse. The aim of this exploratory study was to determine whether a portable high-resolution PET scanner could be used to image the equine distal limb. Images of the front feet and fetlocks of three research horses, with known lesions localized to the distal front limbs, were acquired under general anesthesia after administration of F-fluorodeoxyglucose ( F-FDG), with doses ranging from 1.5 to 2.9 MBq/kg. The radiation exposure measured during imaging was slightly higher than Technetium scintigraphy. However, the use of general anesthesia allowed the proximity and the contact time with the patient to be minimized for the staff involved. F-FDG uptake was evident throughout the soft tissues, with the highest uptake in the coronary band and the lowest uptake in the tendons. Anatomic structures could be discriminated due to the high contrast between soft tissue and bone. Detected lesions included lysis of the flexor cortex of the navicular bone, lesions of flexor tendons and suspensory ligament, and abnormal uptake through the lamina of a laminitic subject. Findings indicated that tomographic molecular imaging is feasible in the equine distal limb and could be useful as a future diagnostic technique for clinical and research studies, especially those involving tendinopathy/desmopathy and laminitis.

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Section: Introductionmentioning

confidence: 99%

Positron Emission Tomography of the Equine Distal Limb: Exploratory Study

Spriet

Espinosa

Kyme

et al. 2016

Vet Radiology Ultrasound

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“…Wadą badania PET, bez względu na rodzaj stosowanych znaczników, jest niska rozdzielczość obrazu (4-6 mm) w porównaniu do tomografii i rezonansu (1-2 mm), co prowadzi do trudności w identyfikacji zmian o wielkości poniżej 1 cm i przez to możliwości wystąpienia wyników fałszywie ujemnych (23,24,32,43,55). W przypadku ognisk przerzutów poniżej 2 mm czułość badania PET/CT wynosi 11% (23,24).…”

Section: Zasada Działania Petunclassified

“…Badanie PET ma także szerokie zastosowanie w kardiologii i neuropsychiatrii (2,33,39,49,57). W neurologii badanie PET ma zastosowanie w ocenie metabolizmu centralnego układu nerwowego i jego perfuzji (55). Badania diagnostyczne obejmują ocenę obecności zmian zapalnych, a także różnicowanie zmian nowotworowych ze zmianami innego tła, takimi jak blizny czy zmiany martwicze w przypadku niejednoznacznych wcześniejszych badań diagnostycznych (2,11,57).…”

Section: Zasada Działania Petunclassified

“…Pozytonowa tomografia emisyjna (PET, positron emission tomography) jest innowacyjną techniką obrazowania z zakresu medycyny nuklearnej, polegającą na wykorzystaniu skanera PET, który bez zastosowania zewnętrznego źródła promieniowania rentgenowskiego lub radioaktywnego rejestruje promieniowanie powstające podczas anihilacji pozytonów (anty-elektronów). Wymaga to wykorzystania radiofarmaceutyków emitujących w ciele badanego pacjenta pozytony, czyli dodatnio naładowane elektrony, zwane również cząstkami beta + (31,43,55), dzięki czemu ta metoda pozwala na wykonanie szybkiego, bezbolesnego i bezpiecznego badania ciała pacjenta. Podczas badania jednocześnie wykonywane jest skanowanie PET, przedstawiające wychwyt zgromadzonego w ciele znacznika oraz tomografia komputerowa, obrazująca struktury anatomiczne ciała.…”

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Use of positron emission tomography in medicine and veterinary medicine

Łojszczyk-Szczepaniak

Dębiak

Jarząbek-Bielecka

et al. 2020

Medycyna Weterynaryjna

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Positron emission tomography (PET) is an imaging technique using positron (anti-electron) radiopharmaceuticals, in which radiation generated during the annihilation of positrons is recorded. This method is used in oncology, neurology and cardiology. PET is of particular importance to oncology, in both scientific and clinical research, especially in the identification and staging of metastatic disease, as well as in therapy planning and control. The use of PET has contributed to the advancement of research into many neurological problems. Data in the literature indicate that PET is widely used in veterinary medicine. PET allows for detailed evaluation of many oncologic and fungal diseases. In neurology, it has been used in necrotizing meningoencephalitis and epilepsy. There have been a number of experimental studies in cardiology, as well, in patients after radiation therapy.

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“…PET and MRI co-registration or integrated PET/MR with simultaneous acquisition is considered superior [ 8 ]. FDG-PET may be useful as a diagnostic test for idiopathic epilepsy in the dog [ 46 , 47 ] Ictal and inter-ictal single-photon emission computed tomography (ictal/inter-ictal SPECT) Injection of a radiolabeled tracer during ictus and inter-ictus. Statistical comparison of the blood flow changes.…”

Section: Introductionmentioning

confidence: 99%

International Veterinary Epilepsy Task Force recommendations for a veterinary epilepsy-specific MRI protocol

et al. 2015

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Epilepsy is one of the most common chronic neurological diseases in veterinary practice. Magnetic resonance imaging (MRI) is regarded as an important diagnostic test to reach the diagnosis of idiopathic epilepsy. However, given that the diagnosis requires the exclusion of other differentials for seizures, the parameters for MRI examination should allow the detection of subtle lesions which may not be obvious with existing techniques. In addition, there are several differentials for idiopathic epilepsy in humans, for example some focal cortical dysplasias, which may only apparent with special sequences, imaging planes and/or particular techniques used in performing the MRI scan. As a result, there is a need to standardize MRI examination in veterinary patients with techniques that reliably diagnose subtle lesions, identify post-seizure changes, and which will allow for future identification of underlying causes of seizures not yet apparent in the veterinary literature.There is a need for a standardized veterinary epilepsy-specific MRI protocol which will facilitate more detailed examination of areas susceptible to generating and perpetuating seizures, is cost efficient, simple to perform and can be adapted for both low and high field scanners. Standardisation of imaging will improve clinical communication and uniformity of case definition between research studies. A 6–7 sequence epilepsy-specific MRI protocol for veterinary patients is proposed and further advanced MR and functional imaging is reviewed.Electronic supplementary materialThe online version of this article (doi:10.1186/s12917-015-0466-x) contains supplementary material, which is available to authorized users.

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Cerebral Glucose Utilization Measured With High Resolution Positron Emission Tomography in Epileptic Finnish Spitz Dogs and Healthy Dogs

Cited by 16 publications

References 43 publications

Positron Emission Tomography of the Equine Distal Limb: Exploratory Study

Positron Emission Tomography of the Equine Distal Limb: Exploratory Study

Use of positron emission tomography in medicine and veterinary medicine

International Veterinary Epilepsy Task Force recommendations for a veterinary epilepsy-specific MRI protocol

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