2018
DOI: 10.1016/j.parkreldis.2018.03.008
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Cerebral gray matter volume losses in essential tremor: A case-control study using high resolution tissue probability maps

Abstract: This study, which uses improved methodologies, provides evidence that GM volume loss in ET is present beyond the cerebellum, and in fact, is widespread throughout the cerebrum as well.

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Cited by 30 publications
(23 citation statements)
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“…Several studies have hitherto investigated ET patients through VBM providing variable and inconsistent results 10 13 . In some agreement with our findings, quite a few studies reported GM volume loss in bilateral cerebellar hemispheres either isolated or associated with GM density reduction in other brain regions, such as occipital lobes 12 , 14 17 . Moreover, Bhalsing et al detected GM volume reduction covering the anterior and posterior lobules of the cerebellum bilaterally in ET associated with cognitive impairment 18 .…”
Section: Discussionsupporting
confidence: 93%
“…Several studies have hitherto investigated ET patients through VBM providing variable and inconsistent results 10 13 . In some agreement with our findings, quite a few studies reported GM volume loss in bilateral cerebellar hemispheres either isolated or associated with GM density reduction in other brain regions, such as occipital lobes 12 , 14 17 . Moreover, Bhalsing et al detected GM volume reduction covering the anterior and posterior lobules of the cerebellum bilaterally in ET associated with cognitive impairment 18 .…”
Section: Discussionsupporting
confidence: 93%
“…Though it is not impossible for memory deficits (or language and spatial deficits) to reflect the distal effects of cerebellar compromise on hippocampal, temporal and parietal regions respectively, such cognitive deficits might be explained more parsimoniously by direct deterioration of these regions, such as that which may occur early in the course of Alzheimer's disease [44][45][46]. Consistent with a neuropathological model of cognitive impairment in ET that extends beyond the cerebellum, diffusion tensor imaging (DTI) studies have shown that the integrity of white matter microstructure is compromised throughout the brain [47], resting state imaging has revealed altered functional connectivity throughout the cerebral cortex [48] [49], and structural MRI has shown smaller cerebral cortical gray matter volume [50]. In at least a subset of ET cases, therefore, there appears to be a neurodegenerative process occurring outside of the cerebellum at a higher rate than that which is seen in age matched controls [47,51].…”
Section: Nature and Neuroanatomic Substrates Of Cognitive Impairment mentioning
confidence: 90%
“…The extent to which cognitive impairment in ET increases risk for these endpoints is unknown. Finally, although compromise to both the structure and function of cortical regions has been documented in ET [47][48][49][50][51], the specific neuropathologies underlying these changes, and contributing to cognitive impairment in ET are unknown. Below, we review the state of knowledge in the general population and in PD so as to develop a roadmap for investigating these issues in ET.…”
Section: What We Do Not Knowmentioning
confidence: 99%
“…In our study, the ETh group showed higher scores and frequency of ecmnesia than those in the ETol group. We obtained little information on the cognitive level in the patients with ETh; however, neuroimaging studies have demonstrated that the poorer cognitive performance in patients with ET might be related to gray matter atrophy or cerebellar‐cortex dysfunction, 10,26 which suggests that worse deterioration occurs in patients with ETh.…”
Section: Discussionmentioning
confidence: 93%